Tac1 regulation by RNA-binding protein and miRNA in bone marrow stroma: Implication for hematopoietic activity

Murthy, Raghav G.; Greco, Steven J.; Taborga, Marcelo; Patel, Nitixa; Rameshwar, Pranela

doi:10.1016/j.bbi.2007.10.009

Cited by 12 publications

(18 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The studies published in this series encompass the anatomical localization of peptidergic nerve fibers in close proximity to lymphocytes (Shibata et al, 2008), the potent anti-inflammatory activity of neuropeptides/hormones such as vasoactive intestinal peptide (VIP), endomorphin 1 and 2, and alpha-melanocyte stimulating hormone (α-MSH) Gutierrez-Canas et al, 2008;Taylor and Kitaichi, 2008;Colombo et al, 2008;Anton et al, 2008), the regulation of neuropeptide receptor expression in immune cells (Murthy et al, 2008;Vornhof-DeKrey et al, 2008a and b), and the dependence of immune parameters such as thymus involution and T lymphocyte output, in addition to growth hormone expression, on signalling through ghrelin receptors (Yang et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agents

Delgado

Ganea

2008

Brain, Behavior, and Immunity

103

View full text Add to dashboard Cite

Resolution of inflammation and induction of immune tolerance are essential to stabilize immune homeostasis and to limit the occurrence of exacerbated inflammatory and autoimmune conditions. Multiple mechanisms act together to ensure the re-establishment of immune homeostasis and maintenance of tolerance. The identification of endogenous factors that regulate these processes is crucial for the development of new therapies for inflammatory/autoimmune conditions. Neuropeptides produced during an ongoing inflammatory response emerged as endogenous antiinflammatory agents that participate in processes leading to the resolution of inflammation and maintenance of tolerance. Anti-inflammatory neuropeptides and hormones such as vasoactive intestinal peptide, urocortin, adrenomedullin, melanocyte stimulating hormone, ghrelin and cortistatin have beneficial effects in a variety of experimental inflammatory and autoimmune models. Their therapeutic effect has been attributed to their capacity to downregulate innate immunity, to inhibit antigen-specific T H 1-driven responses, and to generate regulatory T cells. Finally, some of these neuropeptides have been identified as mediators of innate defense acting as natural antimicrobial peptides. Here we present the research findings in the neuropeptide immunoregulatory field, and examine possible therapies based on anti-inflammatory neuropeptides and hormones as a new pharmacologic platform.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agents

Delgado

Ganea

2008

Brain, Behavior, and Immunity

103

View full text Add to dashboard Cite

show abstract

“…2010;14(5) Function TAC1 peptides function in both pathologic and physiologic processes. These include hematopoiesis, gastrointestinal secretory processes, respiratory patterns, calcium signaling, neuropeptide signaling, pain, synaptic transmission, insemination (Murthy et al, 2008;David et al, 2009); inflammatory response, autism, and pulmonary infection (Marui et al, 2007;Grissell et al, 2007). In normal respiratory development, TAC1 appears to be a crucial gene, exerting plasticity during development (Berner et al, 2007).…”

Section: Tac1 (Tachykinin Precursor 1)mentioning

confidence: 99%

“…TAC1 is involved in hematopoietic regulation. The mRNA is targeted by RNA-binding protein that confers translational control, which could be negatively regulated by cytokines with hematopoietic stimulator properties (Murthy et al, 2008). TAC1 has been implicated in macrophage and monocyte functions (Chernova et al, 2009).…”

Section: Tac1 (Tachykinin Precursor 1)mentioning

confidence: 99%

TAC1 (tachykinin, precursor 1)

Lim¹,

Sa²,

Rameshwar³

2011

Atlas of Genetics and Cytogenetics in Oncology and Haematology

View full text Add to dashboard Cite

“…The negatively selected cells were subjected to real-time RT-PCR for miR-130a and miR-206 with 2 μg of total RNA as described. 25 The RNA was subjected to reverse transcription and then amplified by the mirVana qRT-PCR miRNA Detection Kit (Ambion, Austin, TX, USA), according to the manufacturer's specified guidelines. Primers for miR-130a (Accession No.…”

Section: Real-time Rt-pcrmentioning

confidence: 99%

Immunostimulatory Effects of Mesenchymal Stem Cell‐Derived Neurons: Implications for Stem Cell Therapy in Allogeneic Transplantations

Castillo

Trzaska

Greco

et al. 2008

Clinical Translational Sci

Self Cite

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) differentiate along various lineages to specialized mesodermal cells and also transdifferentiate into cells such as ectodermal neurons. MSCs are among the leading adult stem cells for application in regenerative medicine. Advantages include their immune‐suppressive properties and reduced ethical concerns. MSCs also show immune‐enhancing functions. Major histocompatibility complex II (MHC‐II) is expected to be downregulated in MSCs during neurogenesis. Ideally, “off the shelf” MSCs would be suited for rapid delivery into patients. The question is whether these MSC‐derived neurons can reexpress MHC‐II in a milieu of inflammation. Western analyses demonstrated gradual decrease in MHC‐II during neurogenesis, which correlated with the expression of nuclear CIITA, the master regulator of MHC‐II expression. MHC‐II expression was reversed by exogenous IFNY. One‐way mixed lymphocyte reaction with partly differentiated neurons showed a stimulatory effect, which was partly explained by the release of the proinflammatory neurotransmitter substance P (SP), cytokines, and decreases in miR‐130a and miR‐206. The anti‐inflammatory neurotransmitters VIP and CGRP were decreased at the peak time of immune stimulation. In summary, MSC‐derived neurons show decreased MHC‐II expression, which could be reexpressed by IFNY. The release of neurotransmitters could be involved in initiating inflammation, underscoring the relevance of immune responses as consideration for stem cell therapies.

show abstract

Tac1 regulation by RNA-binding protein and miRNA in bone marrow stroma: Implication for hematopoietic activity

Cited by 12 publications

References 42 publications

Anti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agents

Anti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agents

TAC1 (tachykinin, precursor 1)

Immunostimulatory Effects of Mesenchymal Stem Cell‐Derived Neurons: Implications for Stem Cell Therapy in Allogeneic Transplantations

Contact Info

Product

Resources

About