Tableting of fluidized bed granules containing living microorganisms

Vorländer, Karl; Bahlmann, Lukas; Kwade, Arno; Finke, Jan Henrik; Kampen, Ingo

doi:10.1016/j.ejpb.2023.03.011

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…The survival rate and physical properties of the tablets were significantly influenced by the choice of carrier material and the applied compression stress. These dependencies were attributed to the specific deformation characteristics of the materials and were connected to mechanistic approaches aimed at explaining the observed variations in sensitivities [7,8]. So, the influence of tableting speed on mechanical tablet properties was intensively studied for different materials.…”

Section: Excipientsmentioning

confidence: 99%

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10. Literature Review of Research and Development of Probiotic Tablets

Anh,

Xuan,

Chien

2023

YHCĐ

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Probiotics are gaining increasing attention due to their significant benefits to the host. Despite their potential advantages, probiotic dosage forms have not been extensively studied, primarily because of their poor survival through the gastrointestinal tract. Probiotic tablets emerge as a promising delivery system utilized in nutritional products to supplement the natural intestinal flora. These tablets possess the capability to deliver live, functional bacteria in sufficiently large quantities, ensuring effectiveness, and providing protection against the harsh conditions of the gastrointestinal and biliary tract environment, thereby ensuring in vivo protection and maintaining viability during preparation. Various adverse effects that impact the effectiveness of probiotics are associated with preparation methods and user factors. This review primarily focuses on probiotic tablets, delving into factors influencing the existence of microorganisms and the development of formulations for probiotic tablets.

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Section: Excipientsmentioning

confidence: 99%

“…Tablets and capsules are convenient solid dosage forms for delivering probiotics. These formulations allow the application of various functional excipients to improve shelf life, gastrointestinal stability, cell viability and also to control release rate and target location of probiotics [4,8].…”

Section: Introduction 1probiotic Tabletmentioning

confidence: 99%

10. Literature Review of Research and Development of Probiotic Tablets

Anh,

Xuan,

Chien

2023

YHCĐ

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Advancement and Innovations in Drying of Biopharmaceuticals, Nutraceuticals, and Functional Foods

Ramachandran,

Nadimi,

Cenkowski

et al. 2024

Food Eng Rev

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Drying is a crucial unit operation within the functional foods and biopharmaceutical industries, acting as a fundamental preservation technique and a mechanism to maintain these products' bioactive components and nutritional values. The heat-sensitive bioactive components, which carry critical quality attributes, necessitate a meticulous selection of drying methods and conditions backed by robust research. In this review, we investigate challenges associated with drying these heat-sensitive materials and examine the impact of various drying methods. Our thorough research extensively covers ten notable drying methods: heat pump drying, freeze-drying, spray drying, vacuum drying, fluidized bed drying, superheated steam drying, infrared drying, microwave drying, osmotic drying, vacuum drying, and supercritical fluid drying. Each method is tailored to address the requirements of specific functional foods and biopharmaceuticals and provides a comprehensive account of each technique's inherent advantages and potential limitations. Further, the review ventures into the exploration of combined hybrid drying techniques and smart drying technologies with industry 4.0 tools such as automation, AI, machine learning, IoT, and cyber-physical systems. These innovative methods are designed to enhance product performance and elevate the quality of the final product in the drying of functional foods and biopharmaceuticals. Through a thorough survey of the drying landscape, this review illuminates the intricacies of these operations and underscores their pivotal role in functional foods and biopharmaceutical production.

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