Tablet Formulation with Galactomannan Binding Agent and Acute Toxicity Test from Terminalia catappa L.

Zebua, Nilsya Febrika; Alexandro, Tandra; Pratiwi, Virda Widya; Nadia, Syarifah; Hidayat, Supran; Fujiko, Muflihah; Saputri, Muharni; Bakri, Tedy Kurniawan; Nerdy, Nerdy

doi:10.26554/sti.2023.8.1.129-136

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Flavonoid test: several grams of Solanum erianthum extract are dissolved in methanol, then added with magnesium powder, and HCl(p) is added. It is said to be positive if it shows an intense red reaction [14]. Saponin test: when some simplicia is dissolved in hot water and shaken vigorously, it is said to be positive if a stable foam forms; when dropped with HCl, the foam does not disappear.…”

Section: Phytochemical Screening Of Extractsmentioning

confidence: 99%

Analysis of Flavonoid Content and Antioxidant Activity of Solanum ertianthum Extract

Zebua,

Fujiko,

Dachi

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Solanum erianthum is one of the herbal plants that is believed by the Indonesian people to be a medicinal plant. The flavonoid and polyphenol compounds contained therein have antioxidant activity, but this has not been proven empirically. Solanum erianthum extract is produced using the maceration method. The determination of total flavonoid levels in Solanum erianthum was measured using a method based on complex formation, namely the aluminum trichloride (AlCl3) method. The antioxidant activity of Solanum erianthum was measured using the DPPH (1,1-diphenyl-2-2picrihydrazyl) method because of its stability in the form of free radicals and because it is simple to carry out. The results obtained after determining the total flavonoid content in Solanum erianthum extract with various concentrations using the aluminum trioxide method were 1,430 mg QE/g, 2,282 mg QE/g, 3,180 mg QE/g, 3,567 mg QE/g, 4,291 mg QE/g. Solanum erianthum extract demonstrated antioxidant activity in the DPPH test, with an IC50 value of 66.493 g/ml. This falls into the “strong” category. This research shows that the phytochemical screening content of Solanum erianthum extract contains alkaloids, flavonoids, tannins, saponins, and tritepenoids. The total flavonoid content in Solanum erianthum extract at concentrations of 6 µg/ml, 8 µg/ml, 10 µg/ml, 12 µg/ml, and 14 µg/ml is as follows: 1,430mg QE/g, 2,282mg QE/g, 3,180mg QE/g, 3,567mg QE/g, and 4,291mg QE/g, as well as the antioxidant activity of Solanum erianthum extract with an average yield of 69,493 ppm.

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Section: Phytochemical Screening Of Extractsmentioning

confidence: 99%

Analysis of Flavonoid Content and Antioxidant Activity of Solanum ertianthum Extract

Zebua,

Fujiko,

Dachi

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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“…Terbentuk Endapan disaring melalui kain putih dan direndametanol. Residu disaring lagi dan dikeringkan dalam pengering desicator (Zebua et al, 2023).…”

Section: Ekstraksi Galaktomanan Dari Kolang-kalingunclassified

Pembuatan Sediaan Gel Anti Acne dari Asap Cair Tempurung Kelapa Berbasis Galaktomanan dengan Bakteri Staphylococcus aureus

Zebua,

Yulia,

Zulkarnain

2023

jharma

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Liquid smoke is a condensate liquid resulting from coconut shell pyrolysis which contains the main constituents of acids, phenols and carbonyls, so it is widely applied as a natural preservative in food and as an anti-bacterial. Gel preparations are preferred because when used they leave a translucent, elastic layer, good drug release and an attractive appearance. This study aims to determine whether liquid smoke can be formulated into an acne gel dosage form on a galactomannan basis which at certain concentrations has antimicrobial activity againstStaphylococcus aureus and does not cause skin irritation. This research was conducted using experimental and descriptive methods. Beginning with collecting literature information related to the content of liquid smoke from coconut shells, then making a galactomannan base, formulation of acne gel preparations from liquid smoke, making microbiological media, methods of testing antimicrobial activity, examining the physical quality of preparations including preparation homogeneity, testing the preparation's pH, testing preparation stability, and irritation test on volunteers. Based on the results of the study, it was shown that liquid smoke can be formulated into an acne gel dosage form based on galactomannan. Homogeneity test results on gel preparations remained homogeneous, the pH obtained remained stable, skin irritation test results did not cause irritation, preparation viscosity test results obtained between 4520-9990 mPas, gel preparation test on growthStaphylococcus aureus at a concentration of 5% gives an inhibition of 15.3 mm and the results of the antibacterial activity test on liquid smoke can inhibit growthStaphylococcus aureus in the minimum range of 12.5 mg/ml gives an inhibitory diameter of 7.0 mm which is included in the medium category.

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Tablet Formulation with Galactomannan Binding Agent and Acute Toxicity Test from Terminalia catappa L.

Cited by 2 publications

References 12 publications

Analysis of Flavonoid Content and Antioxidant Activity of Solanum ertianthum Extract

Analysis of Flavonoid Content and Antioxidant Activity of Solanum ertianthum Extract

Pembuatan Sediaan Gel Anti Acne dari Asap Cair Tempurung Kelapa Berbasis Galaktomanan dengan Bakteri Staphylococcus aureus

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