Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii

Mudrić, Jelena; Arsenijević, Jelena; Maksimović, Zoran; Ibrić, Svetlana; Gopčević, Kristina; Đuriš, Jelena

doi:10.1016/j.jddst.2021.102776

Cited by 6 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, to the best of our knowledge, clinopodic acids O and K, i.e. HCA hexamers, were reported only in the extracts of S. biflora, S. hortensis L., and previously analyzed ethanol extracts of S. kitaibelii 15,33,44 , in addition to a few other Lamiaceae species 45,46 . In the previously analyzed polar extracts of savory species, in addition to various flavone glycosides, a limited number of flavonol and flavanone glycosides were found, which is consistent with the currently analyzed aqueous extracts of S. kitaibelii.…”

Section: Discussionmentioning

confidence: 84%

Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction

Gopčević

Grujić

Arsenijević

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

The aim of the study was to investigate the biological activity and chemical composition of Satureja kitaibelii Wierzb. ex Heuff. LC–PDA/MS analyses for the aqueous extracts (A1-stem, leaves and flowers, A2-leaves and flowers) and ethyl-acetate extracts (E1-stem, leaves and flowers, E2-leaves and flowers) obtained by ultrasound-assisted extraction enabled the identification of thirty-four compounds. Quantitative analysis revealed that the aqueous extract obtained from leaves and flowers was the richest in total phenolic acids (65.36 mg/g) and flavonoids (21.17 mg/g). The total polyphenol content was the highest in the aqueous extract obtained from leaves and flowers (274 ± 2.4 mg Gallic Acid equivalents/g). The best antioxidant activity was observed for the same extract using the DPPH (SC50 20 ± 10 µg/mL), ABTS (2.834 ± 0.02 mg Ascorbic Acid/g), FRAP (1.922 ± 0.03 mmol Fe2+/mg), and total reducing power tests (16.4 ± 1.0 mg Ascorbic Acid/g). Both ethyl acetate extracts were the most active against strains of Bacillus cereus and Micrococcus flavus (MIC 1.70–1.99 mg/mL and 1.99–3.41 mg/mL, respectively). They were more efficient against Aspergillus ochraceus (MFC 0.86 mg/mL) and towards HeLa cell lines. All the obtained results implied the good potential of the investigated extracts to be used as effective preservatives and functional ingredients in food products and dietary supplements.

show abstract

Section: Discussionmentioning

confidence: 84%

Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction

Gopčević

Grujić

Arsenijević

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…The results, presented in Table 5, revealed that formulated powders (A-D) were characterized with fair to excellent flowability according to the European Pharmacopoeia [1]. On the other hand, the dry gentian extract showed poorer properties, possibly as a result of the amorphous structure and unfavorable physicochemical and mechanical properties of dry herbal extracts that could cause the poor flowability of powders and compressibility in the tablet compression process [36]. Therefore, this result indicates that encapsulation of the extract in the double emulsion prior to freeze-drying improves the processability of this material.…”

Section: Flowabilitymentioning

confidence: 99%

Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion–Melt Dispersion Technique

et al. 2021

Self Cite

View full text Add to dashboard Cite

Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside. The aim of study was to encapsulate GRE in the lipid-based gastroretentive delivery system that could provide high yield and encapsulation efficiency, as well as the biphasic release of gentiopicroside from the tablets obtained by direct compression. Solid lipid microparticles (SLM) loaded with GRE were prepared by freeze-drying double (W/O/W) emulsions, which were obtained by a multiple emulsion–melt dispersion technique, with GRE as the inner water phase, Gelucire® 39/01 or 43/01, as lipid components, with or without the addition of porous silica (Sylysia® 350) in the outer water phase. Formulated SLM powders were examined by SEM and mercury intrusion porosimetry, as well as by determination of yield, encapsulation efficiency, and flow properties. Furthermore, in vitro dissolution of gentiopicroside, the size of the dispersed systems, mechanical properties, and mucoadhesion of tablets obtained by direct compression were investigated. The results have revealed that SLM with the macroporous structure were formulated, and, consequently, the powders floated immediately in the acidic medium. Formulation with porous silica (Sylysia® 350) and Gelucire® 43/01 as a solid lipid was characterized with the high yield end encapsulation efficiency. Furthermore, the mucoadhesive properties of tablets obtained by direct compression of that formulation, as well as the biphasic release of gentiopicroside, presence of nanoassociates in dissolution medium, and optimal mechanical properties indicated that a promising lipid-based gastroretentive system for GRE was developed.

show abstract

Quality-By-Design Strategy for Developing Novel Herbal Products

Devangan,

Bajad,

Loharkar

et al. 2024

Introduction to Quality by Design (QbD)

View full text Add to dashboard Cite

Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii

Cited by 6 publications

References 23 publications

Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction

Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction

Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion–Melt Dispersion Technique

Quality-By-Design Strategy for Developing Novel Herbal Products

Contact Info

Product

Resources

About