Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination

Zhang, Depeng; Li, Xiaozong; Hu, Yudong; Jiang, Huimin; Wu, Yaxian; Ding, Yue; Yu, Kaikai; He, Huiqiong; Xu, Jingsong; Sun, Lei; Qian, Feng

doi:10.1016/j.bcp.2018.05.004

Cited by 57 publications

(32 citation statements)

References 55 publications

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“…Co-IP assay was performed according to a previous study [44]. Briefly, brain samples were lysed in iced cold PIPA buffer and the supernatants were collected by centrifuging at 14000rpm.…”

Section: Methodsmentioning

confidence: 99%

Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

Huang

et al. 2019

Aging

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Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported to treat cardiovascular diseases, chronic kidney disease and diabetes mellitus. However, whether Prob has an effect on age-related neurodegenerative diseases remains unknown. In the study, it was found that Prob ameliorated D-galactose (D-gal) induced cognitive deficits and neuronal loss in the hippocampal CA1 region. Moreover, Prob alleviated ROS and MDA levels by elevating SOD, GSH-PX and HO-1 mRNA and protein expressions, and improving plasmic and cerebral SOD and GSH-PX activities in D-gal treated mice. Furthermore, Prob promoted the dissociation of Keap1/Nrf2 complex leading to the accumulation of Nrf2 in nucleus, implying that the improved anti-oxidant property of Prob is mediated by Keap1/Nrf2 pathway. The study firstly demonstrates the favorable effects of Prob against cognitive impairments in a senescent mouse model, rendering this compound a promising agent for the treatment or prevention of age-related neurodegenerative disease.

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“…Co-IP assay was performed according to a previous study [44]. Briefly, brain samples were lysed in iced cold PIPA buffer and the supernatants were collected by centrifuging at 14000rpm.…”

Section: Methodsmentioning

confidence: 99%

Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

Huang

et al. 2019

Aging

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“…As mentioned above, AA activates host inflammatory response ( Grimble and Tappia, 1998 ; Levick et al, 2007 ). Tabersonine can protect the lung from acute injury via inhibiting ubiquitination of the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6), which plays immuno-inflammatory roles ( Zhang et al, 2018 ). Thus, downregulation of tabersonine may enhance the immune response to clear T. gondii in cerebellum.…”

Section: Resultsmentioning

confidence: 99%

Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomics Reveals Metabolic Alterations in the Mouse Cerebellum During Toxoplasma gondii Infection

Hou

et al. 2020

Front. Microbiol.

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“…Besides, some quinoline and indole alkaloids isolated from Melodinus plants, such as 15-dihydroscandine, 15β-hydroxy-14,15-dihydroscandine, melaxillines A and B, melodinine T, scandine, 11-hydroxytabersonine, and O -methyl-Δ 14 -vincanol-3-one exhibited significant anti-inflammatory activity [ 17 , 28 , 44 , 45 ]. Among the isolates in this study, tabersonine ( 4 ) could attenuate LPS-induced acute lung injury and inhibited LPS-mediated macrophage activation in vitro [ 46 ], 11-hydroxytabersonine ( 5 ) showed inhibitory effect on NO production [ 17 ], tubotaiwine ( 9 ) showed good inhibitions on COX-1 and COX-2 in anti-inflammatory assay in vitro [ 47 ], and melaxilline A ( 14 ), scandine ( 12 ), and meloscandonine ( 15 ) significantly inhibited in release of β-glucuronidase [ 28 ], suggesting these compounds may be responsible for the anti-inflammatory effect of MHTA.…”

Section: Discussionmentioning

confidence: 99%

Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents

Yang

Wang

Fan

et al. 2020

Nat. Prod. Bioprospect.

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Melodinus henryi is a good source of terpenoid indole alkaloids, and traditionally used as a folk medicine in the treatment of meningitis and fracture. In order to further exploit their potential uses, its anti-inflammatory and immunosuppressive activities, safety evaluations and chemical profiles have been illustrated. Compared to the crude methanol extract from M. henryi and its non-alkaloidal fraction, the total alkaloidal fraction (MHTA) had the strongest anti-inflammatory and immunosuppressive activities. In the acute oral toxicity assay, the half lethal dose (LD 50) of MHTA was more than 2000 mg/kg. The sub-acute toxicity assay for consecutive 28 days exhibited MHTA at a lower concentrations of less than 500 mg/kg might be regarded as safe, and might damage spleen, liver, kidney, and heart when the dose is higher than 1000 mg/kg. In addition, a phytochemical investigation on MHTA led to the isolation of 15 monoterpenoid indole alkaloids. Thus, in regard with the potent side effects of MHTA, it should be used with caution in the development of phytomedicine. Meilian Yang and Yudan Wang have contributed equally to this work.

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Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination

Cited by 57 publications

References 55 publications

Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomics Reveals Metabolic Alterations in the Mouse Cerebellum During Toxoplasma gondii Infection

Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents

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