Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties

Abstract

Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive search of the published literature was conducted to locate original publications pertaining to T. impetiginosa up to June 2020. The main inquiry used the following keywords in various combinations in titles and abstracts: T. impetiginosa, Taheebo, traditional uses, phytochemistry, immunopharmacological, anti-inflammatory activity. Immunopharmacological activity described in this paper includes its anti-inflammatory, anti-allergic, anti-autoimmune, and anti-cancer properties. Particularly, T. impetiginosa has a strong effect on anti-inflammatory activity. This paper also describes the target pathway underlying how T. impetiginosa inhibits the inflammatory response. The need for further investigation to identify other pharmacological activities as well as the exact target proteins of T. impetiginosa was also highlighted. T. impetiginosa may provide a new strategy for prevention and treatment of many immunological disorders that foster extensive research to identify potential anti-inflammatory and immunomodulatory compounds and fractions as well as to explore the underlying mechanisms of this herb. Further scientific evidence is required for clinical trials on its immunopharmacological effects and safety.

SKRINING FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN TIGA JENIS TABEBUYA (Tabebuia spp.)

“…Ekstrak metanol daun T. rosea mengandung fenol, tanin, flavonoid, terpenoid, dan alkaloid (Madhumita et al, 2015), sedangkan ekstrak etanol kulit batang T. aurea mengandung flavonoid dan terpenoid (Barbosa-Filho et al, 2004). Spesies Tabebuia di Amerika Selatan bermanfaat sebagai antioksidan, antimikroba, antiinflamasi, analgesik, mengobati radang sendi, sakit gigi, sifilis, malaria, diabetes melitus, dan prostatitis (Ferraz-Filha et al, 2017, Zhang et al, 2020.…”

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

“…Tabebuia impetiginosa (“Lapacho”, the Bignoniaceae family) is a tree with rosy or purple flowers widely distributed among South and Central America. This is a very important medical tree which is used to treat inflammatory diseases, bacterial and viral infections, snake’s venom, and cancer [ 84 ]. In Brazil, T. impetiginosa is the most used plant to cure neoplasia.…”

Avaliação do espectro de bioatividade das estruturas encontradas na tabebuia avellanedae empregando ferramentas in silico

“…Ela pode atingir até 30 metros e perde suas folhas durante as estações secas. Sua casca é utilizada popularmente no combate à malária, infecções, febre, distúrbios estomacais, antineoplásico, anti-inflamatório e analgésico 6,7 . Suas principais propriedades terapêuticas estão relacionadas a três principais moléculas: ácido cafeico, lapachol e β-lapachona que serão elucidadas ao decorrer do estudo.…”