Tabebuia aurea decreases inflammatory, myotoxic and hemorrhagic activities induced by the venom of Bothrops neuwiedi

Reis, Fernanda Paes; Bonfa, Iluska Moslaves Senna; Cavalcante, Rafael Bezerra; Okoba, Denis; Vasconcelos, Simone Bertozi de Souza; Portugal, Luciane Candeloro; Filiú, Wander Fernando de Oliveira; Monreal, Antônio Carlos Duenhas; Silva, Valter Jose da; Rita, Paula Helena Santa; Carollo, Carlos Alexandre; Toffoli-Kadri, Mônica Cristina

doi:10.1016/j.jep.2014.10.045

Cited by 25 publications

(22 citation statements)

References 26 publications

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“…Together, the present results are in agreement with ethnobotanical studies showing that Tabebuia aurea , which contain lapachol, has been used as anti-inflammatory and antiophydic tool in folk medicine [67, 68]. The lapachol analogues, mainly the 3a, could help in the development of a drug with potential therapeutic applications, although further studies are needed, particularly with isolated toxins from the crude venoms which will allow for a better understanding and subsequent application of such compounds.…”

Section: Discussionsupporting

confidence: 88%

Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms

et al. 2019

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BackgroundIt is known that local tissue injuries incurred by snakebites are quickly instilled causing extensive, irreversible, tissue destruction that may include loss of limb function or even amputation. Such injuries are not completely neutralized by the available antivenins, which in general are focused on halting systemic effects. Therefore it is prudent to investigate the potential antiophidic effects of natural and synthetic compounds, perhaps combining them with serum therapy, to potentially attenuate or eliminate the adverse local and systemic effects of snake venom. This study assessed a group of quinones that are widely distributed in nature and constitute an important class of natural products that exhibit a range of biological activities. Of these quinones, lapachol is one of the most important compounds, having been first isolated in 1882 from the bark of Tabebuia avellanedae.Methodology/Principal findingsIt was investigated the ability of lapachol and some new potential active analogues based on the 2-hydroxi-naphthoquinone scaffold to antagonize important activities of Bothrops venoms (Bothrops atrox and Bothrops jararaca) under different experimental protocols in vitro and in vivo. The bioassays used to test the compounds were: procoagulant, phospholipase A2, collagenase and proteolytic activities in vitro, venom-induced hemorrhage, edematogenic, and myotoxic effects in mice. Proteolytic and collagenase activities of Bothrops atrox venom were shown to be inhibited by lapachol and its analogues 3a, 3b, 3c, 3e. The inhibition of these enzymatic activities might help to explain the effects of the analogue 3a in vivo, which decreased skin hemorrhage induced by Bothrops venom. Lapachol and the synthetic analogues 3a and 3b did not inhibit the myotoxic activity induced by Bothrops atrox venom. The negative protective effect of these compounds against the myotoxicity can be partially explained by their lack of ability to effectively inhibit phospholipase A2 venom activity. Bothrops atrox venom also induced edema, which was significantly reduced by the analogue 3a.ConclusionsThis research using a natural quinone and some related synthetic quinone compounds has shown that they exhibit antivenom activity; especially the compound 3a. The data from 3a showed a decrease in inflammatory venom effects, presumably those that are metalloproteinase-derived. Its ability to counteract such snake venom activities contributes to the search for improving the management of venomous snakebites.

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Section: Discussionsupporting

confidence: 88%

Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms

et al. 2019

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“…For example, some studies have shown that anti-inflammatory drugs could inhibit the edematogenic and other snake venom effects related to inflammation, such as necrosis and myotoxicity, induced by Bothrops venoms [ 105 , 106 ]. In fact, many medicinal plants with antiophidic activity also possess significant anti-inflammatory activity in vivo [ 83 , 96 , 107 – 110 ]. Following the same reasoning, some plants with antioxidant activity also possess significant antiophidic effects [ 95 , 96 , 104 , 111 ].…”

Section: Antivenom Activities Of Extracts Of Medicinal Plants Agaimentioning

confidence: 99%

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Félix-Silva

Silva-Júnior

Zucolotto

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many studies have been published giving pharmacological evidence of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities. In this context, this review aimed to provide an updated overview of medicinal plants used popularly as antiophidic agents and discuss the main species with pharmacological studies supporting the uses, with emphasis on plants inhibiting local effects of snake envenomation. The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage.

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“…(Anacardiaceae) is an endemic tree from Brazilian Caatinga, which occurs from the State of Bahia to the State of Paraíba (Engler, 1879). The popular commum names for this species include "baraúna", "braúna", and "quebracho" (Prado et al, 1995;Cardoso et al, 2015).…”

Section: Schinopsis Brasiliensismentioning

confidence: 99%

“…Many plant species from Brazilian Caatinga have shown pharmacological potential, such as Erythrina velutina (Vasconcelos et al, 2007), Tabebuia aurea (Reis et al, 2014), and Ziziphus joazeir (Ribeiro et al, 2013). That fact has raised a lot of attention for plants used in the folk medicine regarding their properties and safety (Varanda, 2006;Albuquerque and Oliveira, 2007;Silva et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity assessment of Schinopsis brasiliensis Engl. (Sapindales: Anacardiaceae) in somatic cells of Drosophila melanogaster (Meigen, 1830) (Diptera: Drosophilidae)

Pantaleão¹,

Santos²,

Linacher³

et al. 2018

Braz. J. Biol. Sci.

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Schinopsis brasiliensisEngl.(Sapindales: Anacardiaceae) has been used in the Brazilian folk medicine to treat several illnesses. However, the phytochemical profile of S. brasiliensis as well as its genotoxic potential are poorly understood, which compromises population safety regarding the medicinal use of this plant species. In this study, we analyzed the genotoxic effects of S. brasiliensis using the Somatic Mutation and Recombination Test (SMART) of Drosophila melanogaster. Larvae from both standard cross (ST) and high bioactivation capacity cross (HB) were exposed to different concentrations of the hydroetanolic extract and ethyl acetate fraction of S. brasiliensis. We analyzed wings from D. melanogaster according to the type and number of mutant hair. Ours results suggested no genotoxic activity of S. brasiliensis in D. melanogaster somatic cells.

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Tabebuia aurea decreases inflammatory, myotoxic and hemorrhagic activities induced by the venom of Bothrops neuwiedi

Cited by 25 publications

References 26 publications

Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms

Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Genotoxicity assessment of Schinopsis brasiliensis Engl. (Sapindales: Anacardiaceae) in somatic cells of Drosophila melanogaster (Meigen, 1830) (Diptera: Drosophilidae)

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