Tabakrauchen und Krebsrisiko

Scherübl, Hans

doi:10.1055/a-1216-7050

Cited by 15 publications

(6 citation statements)

References 23 publications

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“…According to the most recent epidemiological research, obesity, alcohol use, and smoking are among the risk factors for PS ( 19 ). Indeed, several cancers, including pancreatic, liver, esophageal, and lung cancers, are also linked to obesity, drinking, and smoking ( 20 – 22 ). Although there are overlaps in the risk variables for cancers and PS, these confounding factors have not been considered in much prior epidemiological research.…”

Section: Discussionmentioning

confidence: 99%

The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis

Long,

Yang,

Pang

et al. 2024

Front. Oncol.

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BackgroundAlthough observational studies suggest a correlation between psoriasis (PS) and cancers, it is still unknown whether this association can replace causal relationships due to the limitations of observational studies. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis to evaluate the causal relationship between PS and cancers.MethodsPS genetic summary data were obtained from two genome-wide association studies (GWAS). We employed MR Base for individuals retrieving tumors from distinct locations. Inverse-variance weighted analysis was the principal method used for MR, supplemented by weighted median, MR Egger, simple mode, and weighted mode. To investigate the possible link between psoriasis and cancers, we performed two independent two-sample MR studies and a meta-analysis based on two independent MR analyses.ResultsTwo independent MR analyses both found no significant causal relationship between PS and overall cancers (OR=1.0000, 95% confidence interval [CI]:0.9999-1.0001, P=0.984; OR=1.0000, 95% CI:0.9999-1.0001, P=0.761), and no significant causal relationship with 17 site-specific cancers. In the meta-analysis conducted by two two-sample MR analyses, there was no significant causal relationship between PS and overall cancers (OR=1.0000, 95% CI: 0.9999-1.0001, P=1.00, I2 = 0.0%), and there was no significant causal relationship with 17 site-specific cancers.ConclusionsOur findings do not support a genetic link between PS and cancers. More population-based and experimental investigations will be required better to understand the complicated relationship between PS and cancers.

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Section: Discussionmentioning

confidence: 99%

The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis

Long,

Yang,

Pang

et al. 2024

Front. Oncol.

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“…Around 70% of lung cancer patients are smokers or have exposure to second-hand smoke. [26] Since the non-smokers in close periphery of smokers are also exposed to similar or even larger amounts of carcinogens, the risk of cancer development remains the same in both these groups. The amount of suffering and agony that cancer cause to patients and their close family is beyond measure.…”

Section: Cancermentioning

confidence: 99%

Challenges of Second-hand Smoke: Are We Asking the Right Questions?

Sharma

Raghavan

Garg

et al. 2023

Indian J Community Health

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Second-hand tobacco smoke as defined by WHO is the smoke emitted by a smoker or released from a burnt cigarette or any tobacco product. It is highly prevalent all over the globe but its serious health implications are often neglected by the public and the scientific community alike. Second-hand smoke has everlasting impact on all the body’s major organs, especially among the vulnerable population of children, pregnant ladies, people with chronic diseases and senior citizens. Although India started its war against this menace earlier than other counties, all its efforts remain bootless as its approach and implementation have a wide range of lacunae. This review aims to give a big picture of second-hand smoke, highlighting its pathophysiological changes in the body, socioeconomic impact, various strategies, and the gap that prevents these strategies from finding a favorable result in India. It becomes all the more important to reduce its impact owing to the increase in prevalence among youth reducing their vitality, derailing the society and the nation. It is recommended that the health authorities approach this health problem with utmost seriousness as a laid-back approach could welcome this silent killer’s known and unknown repercussions.

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“…Studies have shown that ESCC occurs through the malignant transformation of esophageal epithelial cells, and its lesions are mainly found in the middle esophagus [ 3 ]. Various well-characterized risk factors, such as smoking, excessive alcohol consumption, and salted vegetables, have contributed to the high incidence of ESCC [ 4 ]. Although some progress has been made in diagnosis and treatment, its metastatic and invasive capacity remains a significant difficulty in current treatment [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Upregulation of miR-194-5p or silencing of PRC1 enhances radiotherapy sensitivity in esophageal squamous carcinoma cells

Wang,

Yao,

Sun

2023

Heliyon

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Tabakrauchen und Krebsrisiko

Cited by 15 publications

References 23 publications

The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis

The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis

Challenges of Second-hand Smoke: Are We Asking the Right Questions?

Upregulation of miR-194-5p or silencing of PRC1 enhances radiotherapy sensitivity in esophageal squamous carcinoma cells

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