Tabac et tuberculose

Underner, M.; Perriot, J.

doi:10.1016/j.lpm.2012.02.037

Cited by 25 publications

(20 citation statements)

References 31 publications

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“…Nicotine reduces production of tumour necrosis factor-α by alveolar macrophages [126] rendering the patient more susceptible to progressive disease from latent infection. Tobacco smoke also reduces mucociliary clearance and the immune activity of a variety of cells [141].…”

Section: Biological Mechanismsmentioning

confidence: 99%

Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit

Jiménez-Ruíz¹,

et al. 2015

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Chronic obstructive pulmonary disease (COPD), lung cancer, asthma and pulmonary tuberculosis are common pulmonary diseases that are caused or worsened by tobacco smoking. Growing observational evidence suggests that symptoms and prognosis of these conditions improve upon smoking cessation. Despite increasing numbers of (small) randomised controlled trials suggesting intensive smoking cessation treatments work in people with pulmonary diseases many patients are not given specific advice on the benefits or referred for intensive cessation treatments and, therefore, continue smoking. This is a qualitative review regarding smoking cessation in patients with COPD and other pulmonary disorders, written by a group of European Respiratory Society experts. We describe the epidemiological links between smoking and pulmonary disorders, the evidence for benefits of stopping smoking, how best to assess tobacco dependence and what interventions currently work best to help pulmonary patients quit. Finally, we describe characteristics and management of any "hardcore" smoker who finds it difficult to quit with standard approaches. @ERSpublications Smoking cessation is crucial for respiratory patients: every patient must be given advice and help to quit http://ow.ly/ITgsW

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Section: Biological Mechanismsmentioning

confidence: 99%

Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit

Jiménez-Ruíz¹,

et al. 2015

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“…Tobacco-associated deaths are projected to increase to 8.4 million by 2020 [7], along with TB, both of which are major sources of mortality and morbidity. Various components of the cigarette smoke such as free radicals of oxygen, acrolein, formaldehyde and carbon monoxide increase the oxidative stress in smokers, thus affecting the bronchial mucosa and increasing the threat of Mycobacterium tuberculosis infection [8]. This might be the reason for less effective TB treatment outcomes among specific populations [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…In the current study, the treatment success rate was low among the smokers' group. A person who smokes one packet of cigarettes daily inhales 1.12 µg of iron; iron-loading in the alveolar macrophages makes them more susceptible to the growth of Mycobacterium tuberculosis [22].Cigarette smoke increases the threat of Mycobacterium tuberculosis infection in multiple ways: declined activity of alveolar macrophage, impairment of mucociliary clearance, decrease in the immune response of pulmonary lymphocytes, modified pulmonary dendritic cells activity, and reduction in the cytotoxic activity of natural killer cells[8]. Smoking also produces an alteration in both natural and acquired cell immunity, affecting macrophages and leukocytes.…”

mentioning

confidence: 99%

Effect Of Smoking On Treatment Outcome Among Tuberculosis Patients In Malaysia; A Multicenter Study

Khan

Sulaiman

Hassali

et al. 2020

Preprint

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Background: Smoking plays a key role in the development of tuberculosis (TB) infection and is also a predictor of poor TB treatment prognosis and outcomes. The current study was conducted to determine the prevalence of smoking and to assess the effects of smoking on treatment outcomes among TB patients. Methods: A multi-center retrospective study design was used to collect data from TB patients in four different states of Malaysia, namely Penang, Sabah, Sarawak, and Selangor. The study included medical records of TB patients admitted to the selected hospitals in the period from January 2006 to March 2009. Medical records with incomplete data were not included. Patient demographics and clinical data were collected using a validated data collection form. Results: Of all patients with TB (9337), the prevalence of smokers was 4313 (46.2%). Among smokers, 3584 (83.1%) were associated with pulmonary TB, while 729 (16.9%) were associated with extrapulmonary TB. Male gender (OR= 1.43, 95% CI 1.30-1.58), Chinese ethnicity (OR= 1.23, 95% CI 1.02-1.49), Sarawak indigenous ethnicity (OR= 0.74, 95% CI 0.58-0.95), urban residents (OR= 1.46, 95% CI 1.33-1.61), employed individuals (OR= 1.21, 95% CI 1.09-1.34), alcoholics (OR= 4.91, 95% CI 4.04-5.96), drug abusers (OR= 7.43, 95% CI 5.70-9.60) and presence of co-morbid condition (OR= 1.27, 95% CI 1.16-1.40) all showed significant association with smoking habits. This study found that 3236 (75.0 %) patients were successfully treated in the smokers' group, while 4004 (79.7 %) patients were non-smokers. The proportion of deaths (6.6%, n=283), defaulters (6.6%, n=284) and treatment interruptions (4.7%, n=204) was higher in the smokers' group.Conclusions: Smoking has a strong influence on TB and is a major barrier towards treatment success (OR= 0.76, 95% CI 0.69-0.84, p< 0.001). Therefore, the findings indicate that smoking cessations are an effective way to decrease treatment failure and drug resistance.

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“…Tobacco-associated deaths are projected to increase to 8.4 million by 2020 [7 ], along with TB, both of which are a major source of mortality and morbidity. Various components of the cigarette smoke such as free radicals of oxygen, acrolein, formaldehyde carbon and monoxide increases the oxidative stress in smokers, thus affects the bronchial mucosa and increases the threat of Mycobacterium tuberculosis infection [8], and it might be the affecting reason of less likely TB treatment outcomes among specific population [9,10]. Although the prevalence of TB in Malaysia decreased significantly compared to the early 1990s, still Malaysia is ranked as an intermediate burden country by the World Health Organization (WHO) in 2018 with an incidence rate of 92/100,000 and estimated mortality rate of 4.9/100,000 population [1].…”

Section: Introductionmentioning

confidence: 99%

“…If smoking is responsible for a decrease in cure rates and an increase in the risk of rapid disease progression and severity then there is a clear immunopathological association between smoking and TB[20,21]. In the current study, the treatment success rate was low among smokers groups.A person who smokes one packet of cigarettes daily inhales 1.12 µg of iron; iron loading in the alveolar macrophages makes them more susceptible to the growth of Mycobacterium tuberculosis [22].Cigarette smoke increases the threat of Mycobacterium tuberculosis infection in multiple ways: declined activity of alveolar macrophage, impairment of mucociliary clearance, decrease in the immune response of pulmonary lymphocytes, modified pulmonary dendritic cells activity and reduction in the cytotoxic activity of natural killer cells[8]. Smoking also produces an alteration in both natural and acquired cell immunity, affecting macrophages and leukocytes.…”

mentioning

confidence: 99%

Effect Of Smoking On Treatment Outcome Among Tuberculosis Patients In Malaysia; A Multicentre Study

Khan

Sulaiman

Hassali

et al. 2020

Preprint

View full text Add to dashboard Cite

Background : Smoking plays a key role in the development of tuberculosis (TB) infection and is also a predictor of poor TB treatment prognosis and outcomes. Objectives: To determine the prevalence of smoking and to assess the effects of smoking on treatment outcomes among TB patients. Methods : A multi-center retrospective study design was used to collect data from TB patients in four different states of Malaysia, namely Penang, Sabah, Sarawak, and Selangor. The study included medical records of TB patients admitted to the selected hospitals in the period from January 2006 to March 2009. Medical records with incomplete data were not included. Patient demographics and clinical data were collected using a validated data collection form. Results: Of all patients with TB (9337), the prevalence of smokers was 4313 (46.2%). Among smoker’s, 3584 (83.1%) were associated with pulmonary TB, while 729 (16.9%) were associated with Extra-pulmonary TB. Male gender (OR= 1.43, 95% CI 1.30-1.58), Chinese ethnicity (OR= 1.23, 95% CI 1.02-1.49), Sarawak indigenous ethnicity (OR= 0.74, 95% CI 0.58-0.95), urban residents (OR= 1.46, 95% CI 1.33-1.61), employed individuals (OR= 1.21, 95% CI 1.09-1.34), alcoholics (OR= 4.91, 95% CI 4.04-5.96), drug abusers (OR= 7.43, 95% CI 5.70-9.60) and presence of co-morbid condition (OR= 1.27, 95% CI 1.16-1.40) showed significant association with smoking habit. This study found that 3236 (75.0 %) patients were successfully treated in the smoker group, while 4004 (79.7 %) patients were non-smokers. The proportion of death rate 283 (6.6%), defaulters 284 (6.6%) and treatment interruption 204 (4.7%) was high in the smoker's group. Conclusions: Smoking had a strong influence on TB and is a major barrier towards treatment success (OR= 0.76, 95% CI 0.69-0.84, p< 0.001). Therefore, the findings point out that smoking cessations are an effective way to decrease treatment failure and drug resistance.

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Tabac et tuberculose

Cited by 25 publications

References 31 publications

Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit

Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit

Effect Of Smoking On Treatment Outcome Among Tuberculosis Patients In Malaysia; A Multicenter Study

Effect Of Smoking On Treatment Outcome Among Tuberculosis Patients In Malaysia; A Multicentre Study

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