T2MR can be used as a non-culture-based test together with biomarkers to improve detection of <i>Candida</i> in the bloodstream and reduce time delay in treating invasive candidiasis

Honoré, Patrick M.; Redant, Sebastien; Préseau, Thierry; Moorthamers, Sofie; Kaefer, Keitiane; Gutierrez, Leonel Barreto; Attou, Rachid; Gallerani, Andrea; Bels, David De

doi:10.1080/14787210.2021.1964954

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…In addition, the detection limit is very low, 1-3 cfu/ml whole blood [ 120 ]. This method has a high sensitivity (91.1-100%) and specificity (97.8%-98.9%) for those species [ 121 - 124 ].…”

Section: What Is the Performance Of T2 Magnetic Resonance (T2mr) Cand...mentioning

confidence: 99%

Unresolved issues in the diagnosis of catheter related candidemia: A position paper

Soriano-Martín,

Muñoz,

García-Rodríguez

et al. 2023

Rev Esp Quimioter

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The incidence and recent trends of candidemia and the contribution of the COVID-19 pandemic to its evolution are not well documented. The catheter is a major focus of Candida spp. infections, but the methods used to confirm the origin of candidemia are still based on the data generated for bacterial infection. The presence of Candida spp. on the tip of a removed catheter is the gold standard for confirmation but it is not always possible to remove it. Conservative methods, without catheter removal, have not been specifically studied for microorganisms whose times of growth are different from those of bacteria and therefore these results are not applicable to candidemia. The different Candida species do not have a particular tropism for catheter colonization and fungal biomarkers have not yet been able to contribute to the determination of the origin of candidemia. Techniques such Candida T2 Magnetic Resonance (T2MR) has not yet been applied for this purpose. Finally, there is not yet a consensus of how to proceed when Candida spp. is isolated from an extracted catheter and blood cultures obtained from simultaneous peripheral veins are negative. In this lack of firm data, a group of experts has formulated a series of questions trying to answer them based on the literature, indicating the current deficiencies and offering their own opinion. All authors agree with the conclusions of the manuscript and offer it as a position and discussion paper.

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“…In addition, the detection limit is very low, 1-3 cfu/ml whole blood [ 120 ]. This method has a high sensitivity (91.1-100%) and specificity (97.8%-98.9%) for those species [ 121 - 124 ].…”

Section: What Is the Performance Of T2 Magnetic Resonance (T2mr) Cand...mentioning

confidence: 99%

Unresolved issues in the diagnosis of catheter related candidemia: A position paper

Soriano-Martín,

Muñoz,

García-Rodríguez

et al. 2023

Rev Esp Quimioter

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Invasive candidiasis: current clinical challenges and unmet needs in adult populations

Soriano

Honoré

Puerta‐Alcalde

et al. 2023

Journal of Antimicrobial Chemotherapy

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Invasive candidiasis (IC) is a serious infection caused by several Candida species, and the most common fungal disease in hospitals in high-income countries. Despite overall improvements in health systems and ICU care in the last few decades, as well as the development of different antifungals and microbiological techniques, mortality rates in IC have not substantially improved. The aim of this review is to summarize the main issues underlying the management of adults affected by IC, focusing on specific forms of the infection: IC developed by ICU patients, IC observed in haematological patients, breakthrough candidaemia, sanctuary site candidiasis, intra-abdominal infections and other challenging infections. Several key challenges need to be tackled to improve the clinical management and outcomes of IC patients. These include the lack of global epidemiological data for IC, the limitations of the diagnostic tests and risk scoring tools currently available, the absence of standardized effectiveness outcomes and long-term data for IC, the timing for the initiation of antifungal therapy and the limited recommendations on the optimal step-down therapy from echinocandins to azoles or the total duration of therapy. The availability of new compounds may overcome some of the challenges identified and increase the existing options for management of chronic Candida infections and ambulant patient treatments. However, early identification of patients that require antifungal therapy and treatment of sanctuary site infections remain a challenge and will require further innovations.

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T2MR can be used as a non-culture-based test together with biomarkers to improve detection of Candida in the bloodstream and reduce time delay in treating invasive candidiasis

Abstract: Bels (2021): T2MR can be used as a non-culture-based test together with biomarkers to improve detection of Candida in the bloodstream and reduce time delay in treating invasive candidiasis, Expert Review of Anti-infective Therapy,

Cited by 2 publications

References 15 publications

Unresolved issues in the diagnosis of catheter related candidemia: A position paper

Unresolved issues in the diagnosis of catheter related candidemia: A position paper

Invasive candidiasis: current clinical challenges and unmet needs in adult populations

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