T2-Weighted Dixon Turbo Spin Echo for Accelerated Simultaneous Grading of Whole-Body Skeletal Muscle Fat Infiltration and Edema in Patients With Neuromuscular Diseases

Schlaeger, Sarah; Klupp, Elisabeth; Weidlich, Dominik; Cervantes, Barbara; Foreman, Sarah C.; Deschauer, Marcus; Schöser, Benedikt; Katemann, Christoph; Kooijman, Hendrik; Rummeny, Ernst J.; Zimmer, Claus; Kirschke, Jan S.; Karampinos, Dimitrios C.

doi:10.1097/rct.0000000000000723

Cited by 16 publications

(17 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The muscle tissue in the volume of interest (VOI) was rated based on the 2D Dixon TSE T 2 ‐weighted fat‐ and water‐separated images by one reader using the Mercuri and the Morrow grading scales . Severity of fatty infiltration was assessed via the four‐point Mercuri grading scale with score 1 for muscles with normal appearance, score 2 for muscles with mild fatty infiltration (less than 30% of the volume of the original muscle), score 3 for muscles with moderate fatty infiltration (30 to 60% of the volume of the original muscles), and score 4 for muscles with severe fatty infiltration (greater than 60% of the volume of the original muscle) .…”

Section: Methodsmentioning

confidence: 99%

Decreased water T₂ in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

et al. 2019

Self Cite

View full text Add to dashboard Cite

Quantitative imaging techniques are emerging in the field of magnetic resonance imaging of neuromuscular diseases (NMD). T 2 of water (T 2w ) is considered an important imaging marker to assess acute and chronic alterations of the muscle fibers, being generally interpreted as an indicator for "disease activity" in the muscle tissue.To validate the accuracy and robustness of quantitative imaging methods, 1 H magnetic resonance spectroscopy (MRS) can be used as a gold standard.The purpose of the present work was to investigate T 2w of remaining muscle tissue in regions of higher proton density fat fraction (PDFF) in 40 patients with defined NMD using multi-TE single-voxel 1 H MRS. Patients underwent MR measurements on a 3 T system to perform a multi-TE single-voxel stimulated echo acquisition method (STEAM) MRS (TE = 11/15/20/25(/35) ms) in regions of healthy, edematous and fatty thigh muscle tissue. Muscle regions for MRS were selected based on T 2weighted water and fat images of a two-echo 2D Dixon TSE.MRS results were confined to regions with qualitatively defined remaining muscle tissue without edema and high fat content, based on visual grading of the imaging data.The results showed decreased T 2w values with increasing PDFF with R 2 = 0.45 (p < 10 −3 ) (linear fit) and with R 2 = 0.51 (exponential fit).The observed dependence of T 2w on PDFF should be considered when using T 2w as a marker in NMD imaging and when performing single-voxel MRS for T 2w in regions enclosing edematous, nonedematous and fatty infiltrated muscle tissue. KEYWORDS fatty infiltration, imaging marker, MRS, NMD, PDFF, quantitative imaging techniques, skeletal muscle, T 2 of water Abbreviations used: ALS, amyotrophic lateral sclerosis; CNM, centronuclear myopathy; DM2, myotonic dystrophy type 2; EPG, extended phase graph; FSHD, facioscapulohumeral muscular dystrophy; GRASE, gradient and spin echo; IBM, inclusion body myositis; LGMD2A, limb girdle muscular dystrophy type 2A; LGMD2I, limb girdle muscular dystrophy type 2I; LGMD2L, limb girdle muscular dystrophy type 2L; MESE, multi-echo spin-echo; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; NMD, neuromuscular diseases; PDFF, proton density fat fraction; STEAM, stimulated echo acquisition method; T2f, T2 of fat; T2w, T2 of water; TSE, turbo spin-echo; VOI, volume of interest

show abstract

Section: Methodsmentioning

confidence: 99%

Decreased water T₂ in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Durch körperliches Training konnte in jüngeren und älteren Männern sowohl FF als auch IMAT des Oberschenkels signifikant verringert werden [65]. Darüber hinaus gibt es einige Ganzkörper-Studien, in denen ein Dixon-Protokoll eingesetzt wurde [66][67][68][69]. Aufgrund der begrenzten räumlichen Auflösung sind diese Protokolle zwar zur Messung von FF, aber nicht von IMAT geeignet.…”

Section: D-bildgebung Mit Mrtunclassified

Quantitative MR-Bildgebung zur Charakterisierung der Skelettmuskulatur

2020

View full text Add to dashboard Cite

ZusammenfassungDieser Beitrag gibt einen Überblick über Magnetresonanztomographie-basierte (MRT-basierte) Methoden zur Quantifizierung der Muskeldegeneration. Neben Muskelvolumen kann mit Dixon-Bildgebung insbesondere der prozentuale Fettgehalt bestimmt werden. Daneben gibt es Ansätze, frühe Anzeichen einer Degeneration über die Verteilung des Entzündungsgrades oder der Natriumkonzentration in der Muskulatur zu visualisieren und quantifizieren. Bis auf die Natrium-Bildgebung werden diese Methoden bei Muskelerkrankungen routinemäßig zur Diagnose und Verlaufskontrolle eingesetzt.Im Bereich der Osteologie und Gerontologie wird zwar die Bedeutung der Muskel-Knochen-Einheit unter anderem für Frakturprädiktion und Gebrechlichkeit im Alter immer wieder betont, Degeneration der Muskulatur wird aber im Wesentlichen über extrinsische Parameter wie Muskelkraft und -funktion erfasst. Häufig benutzte intrinsische Parameter wie DXA Lean Mass oder Muskelvolumen, bestimmt mit CT oder MRT, korrelieren nur mäßig mit extrinsischen Parametern. Eine genauere Charakterisierung von Muskelqualität sollte dieses Manko aber beseitigen. Mit CT und MRT stehen entsprechende Methoden zur Verfügung, die jetzt aber in Studien zur altersassoziierten Muskeldegeneration, in Interventionsstudien und in Studien zur Frakturrisikoprognostik auch eingesetzt werden müssen.

show abstract

“…As a further implementation of the Dixon technique, a T2w TSE Dixon approach was used by Schlaeger et al (62) as a fast whole-body simultaneous grading of muscle fat replacement and edema in a mixed cohort of subjects with neuromuscular disorders. The authors documented a high inter-method agreement between traditional T1w Dixon, T2 STIR, and the proposed T2 TSE Dixon for rating fatty infiltration and intramuscular edema, with no need for multiple acquisition stacks to cover the entire body and the possibility to study contemporarily fat replacement and edema.…”

Section: Applications Of Advanced Quantitative Techniquesmentioning

confidence: 99%

“…The authors documented a high inter-method agreement between traditional T1w Dixon, T2 STIR, and the proposed T2 TSE Dixon for rating fatty infiltration and intramuscular edema, with no need for multiple acquisition stacks to cover the entire body and the possibility to study contemporarily fat replacement and edema. As a consequence, T2-weighted Dixon TSE imaging was proposed as a further step in qMRI to obtain an accelerated simultaneous grading of whole-body skeletal muscle fat infiltration and edema (62).…”

Section: Applications Of Advanced Quantitative Techniquesmentioning

confidence: 99%

Advances in Quantitative Imaging of Genetic and Acquired Myopathies: Clinical Applications and Perspectives

et al. 2019

View full text Add to dashboard Cite

In the last years, magnetic resonance imaging (MRI) has become fundamental for the diagnosis and monitoring of myopathies given its ability to show the severity and distribution of pathology, to identify specific patterns of damage distribution and to properly interpret a number of genetic variants. The advances in MR techniques and post-processing software solutions have greatly expanded the potential to assess pathological changes in muscle diseases, and more specifically of myopathies; a number of features can be studied and quantified, ranging from composition, architecture, mechanical properties, perfusion, and function, leading to what is known as quantitative MRI (qMRI). Such techniques can effectively provide a variety of information beyond what can be seen and assessed by conventional MR imaging; their development and application in clinical practice can play an important role in the diagnostic process and in assessing disease course and treatment response. In this review, we briefly discuss the current role of muscle MRI in diagnosing muscle diseases and describe in detail the potential and perspectives of the application of advanced qMRI techniques in this field.

show abstract

T2-Weighted Dixon Turbo Spin Echo for Accelerated Simultaneous Grading of Whole-Body Skeletal Muscle Fat Infiltration and Edema in Patients With Neuromuscular Diseases

Abstract: T2-weighted Dixon TSE imaging is an alternative for accelerated simultaneous grading of whole-body skeletal muscle fat infiltration and edema in patients with NMDs.

Cited by 16 publications

References 21 publications

Decreased water T₂ in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

Decreased water T₂ in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

Quantitative MR-Bildgebung zur Charakterisierung der Skelettmuskulatur

Advances in Quantitative Imaging of Genetic and Acquired Myopathies: Clinical Applications and Perspectives

Contact Info

Product

Resources

About

T2-Weighted Dixon Turbo Spin Echo for Accelerated Simultaneous Grading of Whole-Body Skeletal Muscle Fat Infiltration and Edema in Patients With Neuromuscular Diseases

Abstract: T2-weighted Dixon TSE imaging is an alternative for accelerated simultaneous grading of whole-body skeletal muscle fat infiltration and edema in patients with NMDs.

Cited by 16 publications

References 21 publications

Decreased water T2 in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

Decreased water T2 in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

Quantitative MR-Bildgebung zur Charakterisierung der Skelettmuskulatur

Advances in Quantitative Imaging of Genetic and Acquired Myopathies: Clinical Applications and Perspectives

Contact Info

Product

Resources

About

Decreased water T₂ in fatty infiltrated skeletal muscles of patients with neuromuscular diseases

Decreased water T₂ in fatty infiltrated skeletal muscles of patients with neuromuscular diseases