T2 versus T2*: competitive or complementary sequences?

Betgem, Ryanne P.; Waard, Guus A. de; Nijveldt, Robin; Beek, Aernout M.; Escaned, Javier; Royen, Niels van

doi:10.1038/nrcardio.2014.188-c2

Cited by 1 publication

(2 citation statements)

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“…Nevertheless, despite re-established epicardial blood ow in the IRA, a sizable proportion of patients continue to experience hypoperfusion of myocardial tissue after PPCI, called no-re ow phenomenon. IMH is a form of no-re ow phenomenon resulting from the extensive erythrocyte aggregation and extravasation because of the damaged endothelial walls 5,6 . IMH can be visualized by T2-weighted CMR because breakdown products of hemoglobin are paramagnetic and in uence regional magnetic tissue properties 24 .…”

Section: Discussionmentioning

confidence: 99%

“…Studies have con rmed that up to 40-50% of STEMI patients underwent PPCI may experience no-re ow phenomenon, including microvascular obstruction (MVO) and Intramyocardial hemorrhage (IMH) 3,4 . Among them, ischemic injury of capillaries leads to the occurrence of endothelial gaps and loss of integrity of capillary wall, and extensive erythrocyte extravasation leads to IMH 5,6 . Studies demonstrated that IMH was closely related to infarct size, MVO and impaired left ventricular (LV) function, and major adverse cardiac events (MACEs) [7][8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

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Regulatory T Cell as Predictor of Intramyocardial Hemorrhage in STEMI Patients After Primary PCI

Zhang

Gao

Liu

et al. 2021

Preprint

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Background: Intramyocardial hemorrhage (IMH) is a result of ischemia-reperfusion injury in ST-segment elevation myocardial infarction(STEMI) after primary percutaneous coronary intervention (PPCI). Despite patients with IMH show poorer prognoses, studies investigating predictors of IMH occurrence are scarce. This study firstly investigated the effectiveness of regulatory T cell (Treg), peak value of Creatine Kinase MB (pCKMB), high-sensitivity C-reactive protein (hsCRP), and left ventricular end-systolic diameter (LVESD) as predictors for IMH in STEMI patients received PPCI.Methods: A prospective observational cohort study was performed in STEMI patients with cardiac magnetic resonance examination 6.3±2.3 days after PPCI. Logistic regression analysis was used to screen the risk factors for IMH. The predictive ability of risk factors for IMH were determined by Receiver operating characteristic curves, net reclassification improvement (NRI), integrated discrimination improvement (IDI) and C-index.Results: Of the 182 patients, 80 patients (44.0%) developed IMH. On multivariable analysis, all 4 biomarkers were independent predictors of IMH [odds radio (OR) and 95% confidence interval (CI): 0.350(0.202-0.606) for Treg, 1.004(1.001-1.006) for pCKMB, 1.060(1.022-1.100) for hsCRP, and 3.329(1.346-8.236) for LVESD]. After propensity score matching, the biomarkers individually and together significantly predicted IMH with areas under the curve of 0.750 for Treg, 0.721 for pCKMB, 0.656 for hsCRP, 0.633 for LVESD, and 0.821 for the integrated 4-marker panel. The addition of integrated 4-marker panel to a baseline risk model had an incremental effect on the predictive value for IMH [NRI: 0.197 (0.039 to 0.356); IDI: 0.200 (0.142 to 0.259); C-index: 0.806 (0.744 to 0.869), all p < 0.05].Conclusions: Treg individually or in combination with pCKMB, hsCRP, and LVESD can effectively predict the existence of IMH in STEMI patients received PPCI.Name of the registry: ClinicalTrials. govTrial registration number: NCT03939338Date of registration: 6 May 2019URL of trial registry record: https://clinicaltrials.gov/ct2/show/NCT03939338?term=03939338&cntry=CN&draw=2&rank=1

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Section: Discussionmentioning

confidence: 99%