T2-prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation

Quantification of whole‐brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2‐based oxygenation calibrations

“…Fifth, our study focused primarily on the global OEF and CMRO 2 , which may miss possible changes in local oxygen stress, especially in the white matter, for which the blood volume to ratio is small . However, our study, which establishes a more correct relationship between blood T 2 and oxygenation in SCA patients and demonstrates the applicability of T 2 oximetry in SCA patients, can in the future be combined with T 2 ‐based oximetry mapping techniques to further investigate the local oxygen stress in SCA patients. Finally, we did not track the morphologic change of the erythrocyte.…”

“…Magnetic resonance imaging oximetry using either or T 2 provides an alternative to measure OEF noninvasively. This approach is based on the principle that hemoglobin changes its magnetic property from paramagnetic to diamagnetic when binding oxygen, thereby altering water T 2 and .…”

“…The T 2 oximetry method could alleviate this problem, as it is independent of the tissue environment. The blood T 2 value measured from a large vein can be converted to oxygenation (Y) through a predefined calibration based on the dependence of T 2 on both Y and Hct . Therefore, a proper calibration is crucial to obtain a reliable oxygenation measurement.…”

Prevention, Reduction and Repair of Brain Injury of the Preterm Infant

“…Experimental studies and clinical studies using near infrared spectroscopy (NIRS) showed that prolonged episodes of cerebral oxygen saturation lower than 40–45% were related to damage in the developing brain (Dent et al., 2005, Hou et al., 2007). With NIRS-derived monitoring of cerebral oxygenation and perfusion it is possible to timely identify and intervene during episodes of suboptimal oxygenation and perfusion of the immature brain (Skov et al., 1991; van Bel et al., 2008; Wintermark et al., 2014; Alderliesten et al., 2016; van Bel and Mintzer, 2018). Recently, a European randomized controlled multicenter intervention trial (the SafeboosC study) focusing on the reduction of hypoxia and/or hyperoxia, provided evidence that monitoring cerebral oxygenation with NIRS lowered the hypoxic burden in extremely preterm neonates in the first days after birth (Hyttel-Sorensen et al., 2015), the episode in which most PIVH occur and/or extend.…”

Novel strategies to improve brain development after Encephalopathy of Prematurity: from bench to incubator

“…Experimental studies and clinical studies using near infrared spectroscopy (NIRS) showed that prolonged episodes of cerebral oxygen saturation lower than 40-45% were related to damage in the developing brain (Dent et al, 2005;Hou et al, 2007). With NIRS-derived monitoring of cerebral oxygenation and perfusion it is possible to timely identify and intervene during episodes of suboptimal oxygenation and perfusion of the immature brain (Alderliesten et al, 2016;Skov et al, 1991;Van Bel et al, 2008;van Bel & Mintzer, 2018;Wintermark et al, 2014). Recently, a European randomized controlled multicenter intervention trial (the SafeboosC study) focusing on the reduction of hypoxia and/or hyperoxia, provided evidence that monitoring cerebral oxygenation with NIRS lowered the hypoxic burden in extremely preterm neonates in the first days after birth (Hyttel-Sorensen et al, 2015), the episode in which most PIVH occur and/or extend.…”