T2 Hypointensity Aids in the Diagnosis of Intracranial Metastatic Adenocarcinoma

Aim Brain metastases are seen in 15–40% of patients diagnosed with cancer. We aimed to search the relationship between the T2 hypointensity, diffusion-weighted imaging characteristics, and the presence and amount of vasogenic edema of brain metastasis in magnetic resonance imaging (MRI). Methods A total of 292 patients with brain metastasis were included in the study. T2 signals of metastatic lesions, accompanying diffusion restriction and perilesional vasogenic edema findings, were investigated. In metastases accompanied by vasogenic edema, the largest dimension of the vasogenic edema-mass complex on T2-weighted sequences and the largest dimension of the mass in contrast-enhanced T1-weighted series were measured and the edema-mass ratio (EMR) was calculated by comparing these two values. Results The frequency of vasogenic edema was statistically significantly higher in T2 hypointense metastases (89.1% vs 58.8%, χ2 = 18.949, p = <.001) and metastases accompanied by diffusion restriction(81% vs 61.5%, χ2 = 6.971, p = .008). EMR values were found to be statistically significantly higher in T2 hypointense metastases (EMR→ Z = −4.507, p = <.001) and metastases with diffusion restriction(EMR→ Z = −3.819, p = .001). Conclusions The frequency of vasogenic edema and EMR rates were higher in patients in T2 hypointense metastases and metastases accompanied by diffusion restriction in MRI.

show abstract

“…Studies have found T2 hypointensity in approximately 15% of metastases. 8 T2 hypointensity was observed in 20.9% of metastases in our study.…”

Section: Discussionsupporting

confidence: 57%

The relationship of T2 hypointensity and diffusion restriction of brain metastases with the presence and amount of vasogenic edema in MRI

2023

View full text Add to dashboard Cite

show abstract

“…10 Furthermore, a recently published study indicated that hypointense signal intensity within BM in conventional T2W sequence may aid in the diagnosis of adenocarcinoma histology. 24 However, assessment of BMs with conventional approaches may fail to reflect several characteristics of the tumor such as heterogeneity. Histogram analysis, by its ability to analyze lesions voxel by voxel, can establish the intensity distribution within a VOI and provide quantitative information on tumor characteristics such as symmetry, heterogeneity, and uniformity.…”

Section: Discussionmentioning

confidence: 99%

Histogram Analysis of ADC Maps for Differentiating Brain Metastases From Different Histological Types of Lung Cancers

Bozdağ¹,

Er²,

Çinkooğlu

2020

Can Assoc Radiol J

View full text Add to dashboard Cite

Purpose: Our study aimed to investigate the role of histogram analysis derived from apparent diffusion coefficient (ADC) maps in brain metastases (BMs) from lung cancer for differentiating histological subtype. Methods: A total of 61 BMs (45 non-small cell lung cancer [NSCLC] comprising 32 adenocarcinoma [AC], 13 squamous cell carcinoma [SCC], and 16 small-cell lung cancer [SCLC]) in 50 patients with histopathologically confirmed lung cancer were retrospectively included in this study. Pretreatment cranial diffusion-weighted imaging was performed, and the corresponding ADC maps were generated. Regions of interest were drawn on solid components of the BM on all slices of the ADC maps to obtain parameters, including ADCmax, ADCmean, ADCmin, ADCmedian, ADCrange, skewness, kurtosis, entropy, ADC10, ADC25, ADC75, and ADC90. Apparent diffusion coefficient histogram parameters were compared among histological type groups. Kruskal-Wallis, Mann-Whitney U, chi-square tests, and receiver-operating characteristic (ROC) curve were used for statistical assessment. Results: ADCmin, ADC10, and ADC25 were found to be significantly different among AC, SCC, and SCLC groups; these parameters were higher for AC group, moderate for SCC group, and significantly lower for SCLC group. Skewness and kurtosis were not significantly different among all groups. The ROC analysis for differentiating BMs of NSCLC from SCLC showed that ADC25 achieved the highest area under the curve at 0.922 with 93.02% sensitivity and 81.25% specificity. Conclusion: Apparent diffusion coefficient histogram analysis of BMs from lung cancer has significant prognostic value in differentiating histological subtypes of lung cancer.

show abstract

“…É aventada a possibilidade de o próprio tecido desses tumores ser a fonte do sinal. Porém, ainda não se sabe o motivo físico para este achado (20) .…”

Section: Miscelâneaunclassified

The dark side of T2: lesões do sistema nervoso central com baixo sinal em ponderações T2

Carpentieri-Primo,

Nahoum,

Almeida

et al. 2024

Radiol Bras

View full text Add to dashboard Cite

Resumo A grande maioria das doenças do sistema nervoso central apresenta alto sinal em ponderações T2 na ressonância magnética. As alterações com baixo sinal são menos comuns, de forma que essa característica permite estreitar o diagnóstico diferencial. Analisamos, retrospectivamente, pacientes com imagens de ressonância magnética de crânio e/ou coluna em que este achado foi útil na investigação diagnóstica. Os pacientes foram selecionados no período entre 2015 e 2022 e todos tiveram seus diagnósticos confirmados por estudo clinicorradiológico ou por estudo histopatológico. Obtivemos imagens de 14 pacientes com as seguintes afecções: malformação arteriovenosa, cavernoma, metástase de linfoma, meduloblastoma, tumor embrionário, metástase de melanoma, cisto da bolsa de Rathke, doença de Erdheim-Chester, aspergilose, paracoccidioidomicose, tuberculose, sífilis, doença relacionada à IgG4 e metástase de tumor neuroendócrino de pulmão. Descrevemos lesões de diversas origens etiológicas que, a partir de suas características nas imagens ponderadas em T2, foi possível reduzir o quadro de diagnósticos diferenciais e chegar mais facilmente à hipótese final.

show abstract

T2 Hypointensity Aids in the Diagnosis of Intracranial Metastatic Adenocarcinoma

Cited by 5 publications

References 11 publications

The relationship of T2 hypointensity and diffusion restriction of brain metastases with the presence and amount of vasogenic edema in MRI

The relationship of T2 hypointensity and diffusion restriction of brain metastases with the presence and amount of vasogenic edema in MRI

Histogram Analysis of ADC Maps for Differentiating Brain Metastases From Different Histological Types of Lung Cancers

The dark side of T2: lesões do sistema nervoso central com baixo sinal em ponderações T2

Contact Info

Product

Resources

About