T1ρ MR Imaging Is Sensitive to Evaluate Liver Fibrosis: An Experimental Study in a Rat Biliary Duct Ligation Model

Wáng, Yì Xiáng J.; Yuan, Jing; Chu, Eagle Sh; Go, Minnie Y.Y.; Hua, Huang; Ahuja, Anil T.; Sung, Joseph J.Y.; Yu, Jun

doi:10.1148/radiol.11101638

Cited by 113 publications

(150 citation statements)

References 25 publications

(19 reference statements)

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“…The biophysical mechanism underlying T1rho MRI is thought to be related to the proton exchange and dipole-dipole interactions between the free water pool and macromolecules (such as collagen and proteoglycan [29]). Increased T1rho has been reported in animal models of liver fibrosis with the degree of fibrosis correlated with the degree of increase in T1rho measurements [15]. Chronic kidney disease (CKD) due to LN is characterized by the progressive loss of kidney function resulting from chronic tubulointerstitial injury, which encompasses tubular atrophy and interstitial fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…T1rho MRI is another emerging MRI technique that is sensitive to the presence of macromolecules (such as collagen and proteoglycan [14]). A preclinical study in a rat biliary duct ligation (BDL) model demonstrated that T1rho imaging detected liver fibrosis in BDL rats and that the degree of fibrosis correlated with the degree of increase in T1rho measurements [15].…”

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confidence: 99%

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Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis

Rapacchi

Smith

Wang

et al. 2015

Magnetic Resonance Imaging

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Keywords:Renal function Multi-parametric quantitative MRI (qMRI) Arterial spin labeling (ASL) Blood oxygen level dependent (BOLD) T1rho MRI Lupus nephritis (LN) Purpose: To identify potential biomarkers of the renal impairment in lupus nephritis using a multi-parametric renal quantitative MRI (qMRI) protocol including diffusion weighted imaging (DWI), blood oxygen level dependent (BOLD), arterial spin labeling (ASL) and T1rho MRI between a cohort of healthy volunteers and lupus nephritis (LN) patients. Materials and methods: The renal qMRI protocol was performed twice with repositioning in between on 10 LN patients and 10 matched controls at 1.5 T. Navigator-gated and breath-hold acquisitions followed by non-rigid image registration were used to control respiratory motion. The repeatability of the 4 MRI modalities was evaluated with the intra-class correlation coefficient (ICC) and within-subject coefficient of variation (wsCV). Unpaired t-test and stepwise logistic regression were carried out to evaluate qMRI parameters between the LN and control groups. Results: The reproducibility of the 4 qMRI modalities ranged from moderate to good (ICC = 0.4-0.91, wsCV ≤ 12%) with a few exceptions. T1rho MRI and ASL renal blood flow (RBF) demonstrated significant differences between the LN and control groups. Stepwise logistic regression yielded only one significant parameter (medullar T1rho) in differentiating LN from control groups with 95% accuracy. Conclusion: A reasonable degree of test-retest repeatability and accuracy of a multi-parametric renal qMRI protocol has been demonstrated in healthy volunteers and LN subjects. T1rho and ASL RBF are promising imaging biomarkers of LN.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis

Rapacchi

Smith

Wang

et al. 2015

Magnetic Resonance Imaging

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“…The first is that our technique did not completely suppression micro-vessel blood signal in rat liver. Additional respiration gating was not used in the study, however, as previous studies on rat liver T1ρ imaging (32) and rat liver CEST (38) showed this was not an important obstacle as in rats liver is tightly attached to the posterior wall of the abdominal cavity [for example, image 5 of reference (32), where free breathing is allowed while high quality T1ρ mapping was obtained]. It is highly possible that if respiration gating is applied and further technique improvement is used to fully suppress blood signal in liver, blood signal suppression can be more successful, then the normal liver T1ρ value range will be narrower, and the diagnosis of early liver fibrotic changes can be made with even more confidence.…”

Section: Bdl Is a Well Established Model For Liver Fibrosis Researchmentioning

confidence: 99%

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

Koon¹,

Zhang²,

Chen

et al. 2016

Quant. Imaging Med. Surg.

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Background: To explore black blood T1rho (T1ρ) liver imaging and investigate the earliest stage when biliary duct ligation (BDL) induced liver fibrosis can be diagnosed.Methods: MR was performed at 3 Tesla. A T1ρ prepared 2D fast spin echo (FSE) sequence with acquisition of four spin lock times (TSLs: 1, 10, 30, and 50 msec) and spin-lock frequency of 500 Hz was applied.Inherent black blood effect of FSE and double inversion recovery (DIR) achieved blood signal suppression, and 3 axial sections per liver were obtained. Male Sprague-Dawley rats were scanned at baseline (n=32), and on day-3 (n=13), day-5 (n=11), day-7 (n=10), day-10 (n=4) respectively after BDL. Hematoxylin-eosin (HE) and picrosirius red staining liver histology was obtained at these time points.Results: The physiological liver parenchyma T1ρ was 38.38±1.53 msec (range, 36.05-41.53 msec). Liver T1ρ value elevated progressively after BDL. On day-10 after BDL all experimental animals can be separated from normal liver based on T1ρ measurement with lowest value being 42.82 msec. Day-7 and day-10 liver resembled METAVIR stage-F1/F2 fibrosis, and fibrous area counted for 0.22%±0.13% and 0.38%±0.44% of liver parenchyma area, respectively. Conclusions:This study provides the first proof-of-principle that T1ρ might diagnose early stage liver fibrosis.

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“…With a biliary duct ligation-induced liver fibrosis rat model, we reported that T 1 r MRI is able to detect liver fibrosis, and the degree of fibrosis is correlated with the degree of elevation of the T 1 r measurements [14]. Additionally, our recent study demonstrated T 1 r MRI can be used to assess liver fibrosis induced with CCl4 intoxication of 1 ml kg -1 twice weekly.…”

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confidence: 93%

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Deng

Zhao²,

Yuan³

et al. 2012

BJR

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Objectives: The aim of this study was to explore the technical feasibility of T 1 r MRI for the liver, and to determine the normal range of liver T 1 r in healthy subjects at clinical 3 T. Methods: There were 15 healthy volunteers. Three representative axial slices were selected to cut through the upper, middle and lower liver. A rotary echo spin-lock pulse was implemented in a two-dimensional fast-field echo sequence. Spin-lock frequency was 500 Hz, and the spin-lock times of 1, 10, 20, 30, 40 and 50 ms were used for T 1 r mapping. The images were acquired slice by slice during breath-holding. Regions of interest (ROIs; n55) were manually placed on each slice of the liver parenchyma region, excluding artefacts and vessels. The mean value of these ROIs (n515) was regarded as the liver T 1 r value for the subject. Six subjects were scanned once at fasting status; six subjects were scanned once 2 h post meal; three subjects were scanned twice at fasting status; and seven subjects were scanned twice 2 h post meal. Results: When two readers measured the same 10 data sets, the interreader reproducibility (ICC: intraclass correlation coefficient) was 0.955. With the 10 subjects scanned twice, the ICC for scan-rescan reproducibility was 0.764. There was no significant difference for the liver T 1 r value at the fasting status (43.08¡1.41 ms) and post-meal status (42.97¡2.38 ms, p50.867). Pooling together all the 32 scans in this study, the normal liver T 1 r value ranged from 38.6 to 48.3 ms (mean 43.0 ms, median 42.6 ms). Conclusion: It is feasible to obtain consistent liver T 1 r measurement for human subjects at 3 T.

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T1ρ MR Imaging Is Sensitive to Evaluate Liver Fibrosis: An Experimental Study in a Rat Biliary Duct Ligation Model

Abstract: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101638/-/DC1.

Cited by 113 publications

References 25 publications

Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis

Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

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T1ρ MR Imaging Is Sensitive to Evaluate Liver Fibrosis: An Experimental Study in a Rat Biliary Duct Ligation Model

Abstract: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101638/-/DC1.

Cited by 113 publications

References 25 publications

Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis

Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

LiverT1ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

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LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence