T1ρ and T2 relaxation times predict progression of knee osteoarthritis

Prasad, Annie P.; Nardo, Lorenzo; Schooler, J.; Joseph, G.B.; Link, Thomas M.

doi:10.1016/j.joca.2012.09.011

Cited by 122 publications

(121 citation statements)

References 36 publications

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“…This is important considering the fact that interventions to prevent the onset of OA are likely to be more effective before radiographic changes have occurred. Furthermore, it has been shown that MR relaxation measures of cartilage predict future progression of OA [36,43]. Wise et al [54] also reported that women have greater prevalence of valgus alignment, which was also seen in our cohorts.…”

Section: Discussionsupporting

confidence: 69%

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

Kumar

Souza

MacLeod

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Women are at a greater risk for knee osteoarthritis (OA), but reasons for this greater risk in women are not well understood. It may be possible that differences in cartilage composition and walking mechanics are related to greater OA risk in women.Questions/purposes (1) Do women have higher knee cartilage and meniscus T 1q than men in young healthy, middle-aged non-OA and OA populations? (2) Do women exhibit greater static and dynamic (during walking) knee loading than men in young healthy, middle-aged non-OA and OA populations? Methods Data were collected from three cohorts: (1) young active (\ 35 years) (20 men, 13 women); (2) middleaged (C 35 years) without OA (Kellgren-Lawrence [KL] grade \ 2) (43 men, 65 women); and (3) middle-aged with OA (KL [ 1) (18 men, 25 women). T 1q and T 2 relaxation times for cartilage in the medial knee, lateral knee, and patellofemoral compartments and medial and lateral menisci were quantified with 3.0-T MRI. A subset of the participants underwent three-dimensional motion capture during walking for calculation of peak knee flexion and adduction moments, flexion and adduction impulses, and peak adduction angle. Differences in MR, radiograph, and gait parameters between men and women were compared in the three groups separately using multivariate analysis of variance. Conclusions These data demonstrate differences in cartilage composition and gait mechanics between men and women in young healthy, middle-aged healthy, and OA cohorts. Considering the cross-sectional nature of the study, longitudinal research is needed to investigate if these differences in cartilage composition and walking mechanics are associated with a greater risk of lateral tibiofemoral or patellofemoral OA in women. Future studies should also investigate the relative risk of lateral versus medial patellofemoral cartilage degeneration risk in women compared with men. Level of Evidence Level III, retrospective study.

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Section: Discussionsupporting

confidence: 69%

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

Kumar

Souza

MacLeod

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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“…Nevertheless, to our knowledge, the effect of weight loss on the morphologic degeneration of knee joint tissues has not been assessed. MR imaging is the most sensitive modality with which to depict subtle morphologic abnormalities, and it can reveal early structural osteoarthritic findings, including cartilage and meniscus defects (22)(23)(24).…”

Section: Database and Participantsmentioning

confidence: 99%

Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative

et al. 2017

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“…Additionally, T 1ρ quantification has been used in the attempt to stratify subjects at risk of developing post-traumatic osteoarthritis (PTOA) following anterior cruciate ligament (ACL) injury and reconstruction (11,12). Prolongation of T 1ρ relaxation times has been reported in OA subjects, specifically in the medial compartment (13,14). In contrast, in subjects with ACL injury, elevation in T 1ρ is observed in the posterior lateral tibia immediately after injury, the characteristic site of the pivot shift contusion (15).…”

Section: Introductionmentioning

confidence: 99%

Principal component analysis-T1ρ voxel based relaxometry of the articular cartilage: a comparison of biochemical patterns in osteoarthritis and anterior cruciate ligament subjects

Pedoia¹,

Russell²,

Randolph³

et al. 2016

Quant. Imaging Med. Surg.

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Background: Quantitative MR, including T 1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction.However, limited studies have been performed aimed to assess the spatial location and patterns of T 1ρ . In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T 1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR).Methods: T 1ρ quantitative MRI images were collected for 180 subjects from two separate cohorts. The OA cohort included 93 osteoarthritic patients and 25 age-matched controls. The ACLR-6M cohort included 52 patients with unilateral ACL tears who were imaged 6 months after ACL reconstruction, and 10 agematched controls. Non-rigid registration on a single template and local Z-score conversion were adopted for T 1ρ spatial and intensity normalization of all the images in the dataset. PCA was used as a data dimensionality reduction to obtain a description of all subjects in a 10-dimensional feature space. Logistic linear regression was used to identify distinctive features of OA and ACL subjects Conclusions: This study is the first example of T 1ρ local/regional pattern analysis and data-driven feature extraction in knees with cartilage degeneration. Our results revealed similarities and differences between OA and ACL relaxation patterns that could be potentially useful to better understand the pathogenesis of posttraumatic cartilage degeneration and the identification of imaging biomarkers for the early stratification of subjects at risk for developing post-traumatic OA.

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T1ρ and T2 relaxation times predict progression of knee osteoarthritis

Cited by 122 publications

References 36 publications

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative

Principal component analysis-T1ρ voxel based relaxometry of the articular cartilage: a comparison of biochemical patterns in osteoarthritis and anterior cruciate ligament subjects

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