T1877 Interleukin-18 Upregulates the Apical Sodium-Dependent Bile Acid Transporter (ASBT) in Neonatal Rat Ileum and IEC-6 Cells

Dobrenen, Holly; Patrick, Sarah Mount; Khailová, Ludmila; Dvořák, Bohuslav; Halpern, Melissa D.

doi:10.1016/s0016-5085(10)62755-2

Cited by 2 publications

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“…No changes in BAs concentrations in the ileum were observed at any of the time points, suggesting that the increased ASBT expression may be a compensatory mechanism to the postulated lower intraluminal BAs supply to keep a constant BA pool in the EHC, as ASBT is known to play a major role in BA homeostasis 34 . Moreover, it might also be related to the increased cytokines such as ileal TNF-α and IL-18 levels, which in previous studies www.nature.com/scientificreports/ have been shown to upregulate ASBT expression 35,36 . Of note, intestinal BAs did not contribute to intestinal inflammation 24 , as they were not increased.…”

Section: Discussionmentioning

confidence: 98%

Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus

Heymans

Dulk

Lenaerts

et al. 2021

Sci Rep

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Chorioamnionitis, inflammation of fetal membranes, is an important cause of preterm birth and a risk factor for the development of adverse neonatal outcomes including sepsis and intestinal pathologies. Intestinal bile acids (BAs) accumulation and hepatic cytokine production are involved in adverse intestinal outcomes. These findings triggered us to study the liver and enterohepatic circulation (EHC) following intra-amniotic (IA) lipopolysaccharide (LPS) exposure. An ovine chorioamnionitis model was used in which circulatory cytokines and outcomes of the liver and EHC of preterm lambs were longitudinally assessed following IA administration of 10 mg LPS at 5, 12 or 24h or 2, 4, 8 or 15d before preterm birth. Hepatic inflammation was observed, characterized by increased hepatic cytokine mRNA levels (5h – 2d post IA LPS exposure) and increased erythropoietic clusters (at 8 and 15 days post IA LPS exposure). Besides, 12h after IA LPS exposure, plasma BA levels were increased, whereas gene expression levels of several hepatic BA transporters were decreased. Initial EHC alterations normalized over time. Concluding, IA LPS exposure induces significant time-dependent changes in the fetal liver and EHC. These chorioamnionitis induced changes have potential postnatal consequences and the duration of IA LPS exposure might be essential herein.

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Section: Discussionmentioning

confidence: 98%

Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus

Heymans

Dulk

Lenaerts

et al. 2021

Sci Rep

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“…In chapter 5, we found at two different time points (24h and 8d after IA LPS exposure) an increased expression of ASBT, which might be related to the observed increased ileal cytokine levels such as TNF-α and IL-18 levels, which in previous studies have been shown to upregulate ASBT expression (65,66). Despite increased ASBT expression, ileal BAs remained unchanged.…”

Section: The Effect Of Chorioamnionitis On the Liver And Enterohepatic Circulation Of Bile Acidsmentioning

confidence: 60%

“…Plant sterols, also called phytosterols, are dietary constituents present in vegetable oils, nuts, grains and fruit (59) that are increasingly valued for their immune regulatory properties (60). Plant sterols are found in amniotic fluid (61,62) and human breast milk (63)(64)(65)(66), both fluids that protect against NEC (67,68). Studies in rodent inflammatory bowel disease models and in human volunteers showed that plant sterols possess anti-inflammatory properties (69)(70)(71).…”

Section: Necrotizing Enterocolitismentioning

confidence: 99%

Perinatal inflammation and adverse outcomes of the intestine and liver

Heymans¹

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T1877 Interleukin-18 Upregulates the Apical Sodium-Dependent Bile Acid Transporter (ASBT) in Neonatal Rat Ileum and IEC-6 Cells

Cited by 2 publications

References 0 publications

Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus

Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus

Perinatal inflammation and adverse outcomes of the intestine and liver

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