T1301 Serum Hydrogen Sulfide and Substance P Are Early Clinical Predictors of the Severity of Acute Pancreatitis

Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice

“…In the present study, a significant increase in plasma H 2 S was observed after AP induction. In agreement with our result, a significantly increased plasma H 2 S levels previously found in experimental and clinical AP . The elevated H 2 S level at the acute phase of AP is triggered by CSE and it may induce the severity of pancreatitis and associated lung injury .…”

“…In agreement with our result, a significantly increased plasma H 2 S levels previously found in experimental [10,46] and clinical AP. [47] The elevated H 2 S level at the acute phase of AP is triggered by CSE and it may induce the severity of pancreatitis and associated lung injury. [48] In MSM treated group significant decrease in plasma H 2 S were shown when compared with caerulein treated AP group.…”

Hydrogen sulfide and translational medicine

“…Furthermore, insulin secretion and diabetes mellitus can be affected by local H 2 S concentrations because the pancreas is among the targets of H 2 S 41,42,43,44 . In the pancreas, CSE is the main enzyme converting cysteine to H 2 S. It has also been reported that the concentration of H 2 S rose in response to the presence of pancreatitis, which is ascribed to its pro-inflammatory effect.…”