T1-weighted Dynamic Contrast-enhanced MR Imaging of the Lung in Asthma: Semiquantitative Analysis for the Assessment of Contrast Agent Kinetic Characteristics

Zhang, Weijuan; Niven, Robert; Young, Simon S.; Liu, Yuzhen; Parker, Geoffrey; Naish, Josephine H.

doi:10.1148/radiol.2015141876

Cited by 8 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DCE 1 H-MRI has previously been used to report on lung perfusion defects, [38][39][40] employing T 1 -weighted imaging to monitor GBCA bolus passage through the pulmonary vasculature. The DSC 19 F-MRI approach we present here differs from DCE 1 H-MRI in its ability to report on gas phase PFP directly adjacent to contrast agent that is present within the alveolar microvasculature.…”

Section: Discussionmentioning

confidence: 99%

Dynamic susceptibility contrast ¹⁹F‐MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging

Neal

Pippard

Simpson

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose To assess alveolar perfusion by applying dynamic susceptibility contrast MRI to 19F‐MRI of inhaled perfluoropropane (PFP). We hypothesized that passage of gadolinium‐based contrast agent (GBCA) through the pulmonary microvasculature would reduce magnetic susceptibility differences between water and gas components of the lung, elevating the T2∗ of PFP. Methods Lung‐representative phantoms were constructed of aqueous PFP‐filled foams to characterize the impact of aqueous/gas phase magnetic susceptibility differences on PFP T2∗. Aqueous phase magnetic susceptibility was modulated by addition of different concentrations of GBCA. In vivo studies were performed to measure the impact of intravenously administered GBCA on the T2∗ of inhaled PFP in mice (7.0 Tesla) and in healthy volunteers (3.0 Tesla). Results Perfluoropropane T2∗ was sensitive to modulation of magnetic susceptibility difference between gas and water components of the lung, both in phantom models and in vivo. Negation of aqueous/gas phase magnetic susceptibility difference was achieved in lung‐representative phantoms and in mice, resulting in a ~2 to 3× elevation in PFP T2∗ (3.7 to 8.5 ms and 0.7 to 2.6 ms, respectively). Human studies demonstrated a transient elevation of inhaled PFP T2∗ (1.50 to 1.64 ms) during passage of GBCA bolus through the lung circulation, demonstrating sensitivity to lung perfusion. Conclusion We demonstrate indirect detection of a GBCA in the pulmonary microvasculature via changes to the T2∗ of gas phase PFP within directly adjacent alveoli. This approach holds potential for assessing alveolar perfusion by dynamic susceptibility contrast 19F‐MRI of inhaled PFP, with concurrent assessment of lung ventilation properties, relevant to lung physiology and disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Dynamic susceptibility contrast ¹⁹F‐MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging

Neal

Pippard

Simpson

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…When compared to healthy controls, IPF subjects had reduced peak enhancement and k washin , parameters reflective of the microvasculature, in all measured lung regions on unadjusted analyses, and only reductions in k washin in the whole lung, lower axial and posterior coronal regions remained statistically significant when adjusting for age. A reduced first-pass peak, denoting a reduction in peak enhancement and a slower contrast wash-in rate, has been demonstrated in other pulmonary conditions such as COPD and asthma and was rationalised as decreased tissue perfusion and/or contrast agent extravasation from increased vascular permeability [ 8 , 23 ]. It was recently demonstrated by W eatherley et al [ 11 ] that contrast bolus lung transit time increased over time in IPF consistent with worsening perfusion.…”

Section: Discussionmentioning

confidence: 99%

“…From this information, changes in the microvasculature and the extravascular extracellular space can be quantified [ 5 ]. DCE-MRI is widely performed in brain and breast tumour imaging [ 6 , 7 ] and is starting to be applied to pulmonary conditions [ 8 – 11 ]. Lung MRI has historically been challenging due to motion sensitivity and low signal, but recent MRI advances (radial sampling, sparse sampling, improved reconstruction techniques) enable fast three-dimensional (3D) lung imaging without requiring breath holding or complex registration [ 9 , 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Dynamic contrast-enhanced magnetic resonance imaging of the lung reveals important pathobiology in idiopathic pulmonary fibrosis

et al. 2021

View full text Add to dashboard Cite

IntroductionEvidence suggest that abnormalities occur in the lung microvasculature in idiopathic pulmonary fibrosis (IPF). We hypothesized that dynamic contrast-enhanced (DCE)-MRI could detect alterations in permeability, perfusion, and extracellular extravascular volume in idiopathic pulmonary fibrosis thus providing in vivo regional functional information not otherwise available.MethodsHealthy controls and IPF subjects underwent DCE-MRI of the thorax using a dynamic volumetric radial sampling sequence and administration of gadoterate meglumine at a dose of 0.1 mmol·kg−1 at 2 mL·s−1. Model-free analysis of signal intensity versus time curves in regions of interest from a lower, middle, and upper axial plane and a posterior coronal plane yielded parameters reflective of perfusion and permeability (peak enhancement and rate of contrast arrival, kwashin) and the extracellular extravascular space (rate of contrast clearance, kwashout). These imaging parameters were compared between IPF and healthy control subjects, and between fast/slow IPF progressors.ResultsIPF subjects (n=16, M=56%, age=67.5 (range 60–79)) had significantly reduced peak enhancement and slower kwashin in all measured lung regions compared to the healthy volunteers (n=17, M=65%, age=58 (range 51–63)) on unadjusted analyses consistent with microvascular alterations. kwashout, as a measure of the extravascular extracellular space, was significantly slower in the lower lung and posterior coronal regions in the IPF subjects consistent with an increased extravascular extracellular space. All estimates were attenuated after adjusting for age. Similar trends were observed, but only the associations with kwashin remained statistically significant. Among IPF subjects, kwashout rates nearly perfectly discriminated between those with rapidly progressive disease versus those with stable/slowly progressive disease.ConclusionsDCE-MRI detects changes in the microvasculature and extravascular extracellular space in IPF thus providing in vivo regional functional information.

show abstract

“…Thus, the observed T1 shortening on the second MRI scan performed four (3:41–4:31) hours after the first MRI scan of 3.3(0.3–4.1)% at room air and 1.8(0.1–3.8)% at 100% oxygen (both CF-groups, n = 12) needs to be explained. Recently, a significantly reduced washout of gadolinium-based contrast media in the lung parenchyma was observed using DCE MRI in asthma patients and explained by an increased extravascular space due to interstitial edema or accumulation of fluid within the alveoli and small airways [ 46 ]. Also in a reproducibility study (using 0.1 mmol/kg body weight Gd-DTPA) Triphan et al observed lower T1 values of the lung parenchyma in COPD patients on the second MRI after 23 hours (1124 ms vs 1086 ms; 3,4%)[ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Functional lung MRI for regional monitoring of patients with cystic fibrosis

et al. 2017

View full text Add to dashboard Cite

PurposeTo test quantitative functional lung MRI techniques in young adults with cystic fibrosis (CF) compared to healthy volunteers and to monitor immediate treatment effects of a single inhalation of hypertonic saline in comparison to clinical routine pulmonary function tests.Materials and methodsSixteen clinically stable CF patients and 12 healthy volunteers prospectively underwent two functional lung MRI scans and pulmonary function tests before and 2h after a single treatment of inhaled hypertonic saline or without any treatment. MRI-derived oxygen enhanced T1 relaxation measurements, fractional ventilation, first-pass perfusion parameters and a morpho-functional CF-MRI score were acquired.ResultsCompared to healthy controls functional lung MRI detected and quantified significantly increased ventilation heterogeneity in CF patients. Regional functional lung MRI measures of ventilation and perfusion as well as the CF-MRI score and pulmonary function tests could not detect a significant treatment effect two hours after a single treatment with hypertonic saline in young adults with CF (p>0.05).ConclusionThis study shows the feasibility of functional lung MRI as a non-invasive, radiation-free tool for monitoring patients with CF.

show abstract

T1-weighted Dynamic Contrast-enhanced MR Imaging of the Lung in Asthma: Semiquantitative Analysis for the Assessment of Contrast Agent Kinetic Characteristics

Abstract: The contrast agent kinetic characteristics of T1-weighted DCE MR images of asthmatic lungs are different from those of healthy lungs and are related to measurements of pulmonary function testing but not to eosinophil level.

Cited by 8 publications

References 32 publications

Dynamic susceptibility contrast ¹⁹F‐MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging

Dynamic susceptibility contrast ¹⁹F‐MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging

Dynamic contrast-enhanced magnetic resonance imaging of the lung reveals important pathobiology in idiopathic pulmonary fibrosis

Functional lung MRI for regional monitoring of patients with cystic fibrosis

Contact Info

Product

Resources

About

T1-weighted Dynamic Contrast-enhanced MR Imaging of the Lung in Asthma: Semiquantitative Analysis for the Assessment of Contrast Agent Kinetic Characteristics

Abstract: The contrast agent kinetic characteristics of T1-weighted DCE MR images of asthmatic lungs are different from those of healthy lungs and are related to measurements of pulmonary function testing but not to eosinophil level.

Cited by 8 publications

References 32 publications

Dynamic susceptibility contrast 19F‐MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging

Dynamic susceptibility contrast 19F‐MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging

Dynamic contrast-enhanced magnetic resonance imaging of the lung reveals important pathobiology in idiopathic pulmonary fibrosis

Functional lung MRI for regional monitoring of patients with cystic fibrosis

Contact Info

Product

Resources

About

Dynamic susceptibility contrast ¹⁹F‐MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging

Dynamic susceptibility contrast ¹⁹F‐MRI of inhaled perfluoropropane: a novel approach to combined pulmonary ventilation and perfusion imaging