T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization phantom program (T1MES)

Captur, Gabriella; Bhandari, Abhiyan; Brühl, Rüdiger; Ittermann, Bernd; Keenan, Kathryn E.; Yue, Yang; Eames, Richard J.; Benedetti, Giulia; Torlasco, Camilla; Ricketts, Lewis; Boubertakh, Redha; Fatih, Nasri; Greenwood, John P; Paulis, Leonie E. M.; Lawton, Chris; Bucciarelli-Ducci, Chiara; Lamb, Hildo J.; Steeds, Richard P.; Leung, Steve W.; Berry, Colin; Valentin, Sinitsyn; Flett, Andrew; Lange, Charlotte de; Cobelli, Francesco De; Viallon, Magalie; Croisille, Pierre; Higgins, David M.; Greiser, Andreas; Pang, Wenjie; Hamilton-Craig, C.; Strugnell, W.; Dresselaers, Tom; Barison, Andrea; Dawson, Dana; Taylor, Andrew J.; Mongeon, François‐Pierre; Plein, Sven; Messroghli, Daniel; Al-Mallah, Mouaz; Grieve, Stuart M.; Lombardi, Massimo; Jang, Jihye; Salerno, Michael; Chaturvedi, Nish; Kellman, Peter; Bluemke, David A.; Nezafat, Reza; Gatehouse, Peter; Moon, James

doi:10.1186/s12968-020-00613-3

Cited by 25 publications

(31 citation statements)

References 33 publications

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“…This used the T1 Mapping and ECV Standardization (T1MES) phantom and analysis pipeline. 25 , 26 At the time of COVID patient scanning (September to October 2020), the same phantom was transported between the four scanners in this study (all Siemens Aera 1.5T). After a minimum 8 h equilibrium in the magnet room at each site, the phantom was scanned according to the protocol specified in the T1MES user manual.…”

Section: Methodsmentioning

confidence: 99%

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Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance

Kotecha

Knight

Razvi

et al. 2021

European Heart Journal

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319

344

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Background Troponin elevation is common in hospitalized COVID-19 patients, but underlying aetiologies are ill-defined. We used multi-parametric cardiovascular magnetic resonance (CMR) to assess myocardial injury in recovered COVID-19 patients. Methods and results One hundred and forty-eight patients (64 ± 12 years, 70% male) with severe COVID-19 infection [all requiring hospital admission, 48 (32%) requiring ventilatory support] and troponin elevation discharged from six hospitals underwent convalescent CMR (including adenosine stress perfusion if indicated) at median 68 days. Left ventricular (LV) function was normal in 89% (ejection fraction 67% ± 11%). Late gadolinium enhancement and/or ischaemia was found in 54% (80/148). This comprised myocarditis-like scar in 26% (39/148), infarction and/or ischaemia in 22% (32/148) and dual pathology in 6% (9/148). Myocarditis-like injury was limited to three or less myocardial segments in 88% (35/40) of cases with no associated LV dysfunction; of these, 30% had active myocarditis. Myocardial infarction was found in 19% (28/148) and inducible ischaemia in 26% (20/76) of those undergoing stress perfusion (including 7 with both infarction and ischaemia). Of patients with ischaemic injury pattern, 66% (27/41) had no past history of coronary disease. There was no evidence of diffuse fibrosis or oedema in the remote myocardium (T1: COVID-19 patients 1033 ± 41 ms vs. matched controls 1028 ± 35 ms; T2: COVID-19 46 ± 3 ms vs. matched controls 47 ± 3 ms). Conclusions During convalescence after severe COVID-19 infection with troponin elevation, myocarditis-like injury can be encountered, with limited extent and minimal functional consequence. In a proportion of patients, there is evidence of possible ongoing localized inflammation. A quarter of patients had ischaemic heart disease, of which two-thirds had no previous history. Whether these observed findings represent pre-existing clinically silent disease or de novo COVID-19-related changes remain undetermined. Diffuse oedema or fibrosis was not detected.

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Section: Methodsmentioning

confidence: 99%

“…After a minimum 8 h equilibrium in the magnet room at each site, the phantom was scanned according to the protocol specified in the T1MES user manual. 26 …”

Section: Methodsmentioning

confidence: 99%

Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance

Kotecha

Knight

Razvi

et al. 2021

European Heart Journal

Self Cite

319

344

View full text Add to dashboard Cite

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“…ECV was derived using a same-day hematocrit. Magnet quality assurance used the T1MES phantom to ensure no differences between the 3 magnets and no temporal drift ( 25 , 26 ). Across the 3 magnets, temperature-corrected T 1 and T 2 was within 0.33% and 0.95%, respectively, with temporal drift of <1% ( Supplemental Methods ).…”

Section: Methodsmentioning

confidence: 99%

Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers

Joy

Artico

Kurdi

et al. 2021

JACC: Cardiovascular Imaging

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111

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Objectives The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome coronavirus 2 infection. Background Concern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. Methods Participants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology assessment over 4 months, with seroconversion in 21.5% (n = 157). At 6 months post-infection, 74 seropositive and 75 age-, sex-, and ethnicity-matched seronegative control subjects were recruited for cardiovascular phenotyping (comprehensive phantom-calibrated cardiovascular magnetic resonance and blood biomarkers). Analysis was blinded, using objective artificial intelligence analytics where available. Results A total of 149 subjects (mean age 37 years, range 18 to 63 years, 58% women) were recruited. Seropositive infections had been mild with case definition, noncase definition, and asymptomatic disease in 45 (61%), 18 (24%), and 11 (15%), respectively, with 1 person hospitalized (for 2 days). Between seropositive and seronegative groups, there were no differences in cardiac structure (left ventricular volumes, mass, atrial area), function (ejection fraction, global longitudinal shortening, aortic distensibility), tissue characterization (T 1 , T 2 , extracellular volume fraction mapping, late gadolinium enhancement) or biomarkers (troponin, N-terminal pro–B-type natriuretic peptide). With abnormal defined by the 75 seronegatives (2 SDs from mean, e.g., ejection fraction <54%, septal T 1 >1,072 ms, septal T 2 >52.4 ms), individuals had abnormalities including reduced ejection fraction (n = 2, minimum 50%), T 1 elevation (n = 6), T 2 elevation (n = 9), late gadolinium enhancement (n = 13, median 1%, max 5% of myocardium), biomarker elevation (borderline troponin elevation in 4; all N-terminal pro–B-type natriuretic peptide normal). These were distributed equally between seropositive and seronegative individuals. Conclusions Cardiovascular abnormalities are no more common in seropositive versus seronegative otherwise healthy, workforce representative individuals 6 months post–mild severe acute respiratory syndrome coronavirus 2 infection.

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“…Nevertheless, there is no current standard and reference sequence for T1 or T2 mapping that is widely accepted and distributed. However, standardization initiatives such as the “T1MES” phantom project are promising approaches to increase quality assurance of mapping sequences [ 56 ].…”

Section: Edema Imaging To Differentiate Between Acute and Chronic Myomentioning

confidence: 99%

CMR for myocardial characterization in ischemic heart disease: state-of-the-art and future developments

et al. 2021

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Ischemic heart disease and its sequelae are one of the major contributors to morbidity and mortality worldwide. Over the last decades, technological developments have strengthened the role of noninvasive imaging for detection, risk stratification, and management of patients with ischemic heart disease. Cardiac magnetic resonance (CMR) imaging incorporates both functional and morphological characterization of the heart to determine presence, acuteness, and severity of ischemic heart disease by evaluating myocardial wall motion and function, the presence and extent of myocardial edema, ischemia, and scarring. Currently established clinical protocols have already demonstrated their diagnostic and prognostic value. Nevertheless, there are emerging imaging technologies that provide additional information based on advanced quantification of imaging biomarkers and improved diagnostic accuracy, therefore potentially allowing reduction or avoidance of contrast and/or stressor agents. The aim of this review is to summarize the current state of the art of CMR imaging for ischemic heart disease and to provide insights into promising future developments.

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T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization phantom program (T1MES)

Cited by 25 publications

References 33 publications

Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance

Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance

Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers

CMR for myocardial characterization in ischemic heart disease: state-of-the-art and future developments

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