T1 Glottic Carcinoma

Abstract

ObjectiveRecent large-scale studies have observed differences in survival following treatment for early laryngeal carcinoma depending on treatment type but were not able to take sociodemographic, comorbidity, and facility data into account. The objective of this study was to determine whether survival differences across treatment types persist when these factors are included in the analysis.Study DesignRetrospective cohort analysis.SettingLinked Surveillance, Epidemiology, and End Results (SEER)–Medicare data files.Subjects and MethodsMedicare beneficiaries who were identified through the SEER registries (1991-2009) as having T1 glottic squamous cell carcinoma (scca) and a known treatment type were included.ResultsA total of 2338 patients with incident T1 glottic scca were identified. Most were white and male. Treatment type was radiation only in 47%, local surgery and radiation in 39%, and local surgery only in 14%. Black race and increased comorbidities were associated with worse survival. When sociodemographics, comorbidities, and facility characteristics were taken into account, survival differences were observed across treatment types, with those receiving local surgery demonstrating better overall and cancer-specific survival.ConclusionThese results suggest that following treatment of T1 glottic scca, there may be survival differences across treatment types beyond those explained by sociodemographic, comorbidity, and facility characteristics.

Predictors of Survival in Early-stage Laryngeal Cancer by Treatment Modality

“…While Chen et al included both open and endoscopic techniques in their evaluation, our study only included TLM and excluded for any other open partial surgical therapies. Though using Another recent study by Misono et al 22 looked at patients with T1 glottic lesions and concluded that those patients whose treatment included surgical therapy had better survival than those treated with XRT only. 22 This study utilized the surveillance, epidemiology, and end results (SEER) Medicare database that only includes patients with Medicare Part A and Part B, and only patients older than 66 years.…”

“…Though using Another recent study by Misono et al 22 looked at patients with T1 glottic lesions and concluded that those patients whose treatment included surgical therapy had better survival than those treated with XRT only. 22 This study utilized the surveillance, epidemiology, and end results (SEER) Medicare database that only includes patients with Medicare Part A and Part B, and only patients older than 66 years. In this patient group, these authors found that patients undergoing surgical excision or surgery plus XRT exhibited better overall survival compared with patients who were treated nonsurgically.…”