T1 G1 urinary bladder carcinoma: Fact or fiction?

Mikulowski, Pawel; Hellsten, Sverker

doi:10.1080/00365590510031219

Cited by 28 publications

(18 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study follows the principles of the Declaration of Helsinki and was approved by the Ethical Committee of the University of Athens Medical School. All cases were reviewed by two experienced pathologists (GL and PK) and assigned a histological grade and T-category according to the WHO 2004 classiWcation (Eble et al 2004) and the report of Mikulowski and Hellsten (2004). The clinicopathological characteristics of the patients appear in Table 1.…”

Section: Patientsmentioning

confidence: 99%

D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance

Levidou

Saetta

Κάρλου

et al. 2010

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Cyclin D1 overexpression seems to be more important during early T-categories of bladder carcinogenesis, whereas cyclin D3 is implicated in the acquisition of a more aggressive phenotype. Cyclin D3 overexpression emerges as an independent adverse prognostic marker in both superficial and muscle-invasive tumours. Cyclin D1 is an independent indicator of shortened survival only in muscle-invasive tumours.

show abstract

Section: Patientsmentioning

confidence: 99%

D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance

Levidou

Saetta

Κάρλου

et al. 2010

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…The mean age of patients was 65.48±11.90 ranging from 29 to 89 years, whereas the male-to-female ratio was 103:13. All cases were reviewed by two experienced pathologists (Levidou, Korkolopoulou) and assigned a histological grade and Tcategory according to the latest World Health Organization (WHO) classification [10] and the fifth edition of the TNM classification [46] taking into account the report of Mikulowski and Hellsten [34]. There were 17 tumours of low malignant potential (papillary neoplasms of low malignant potential, PNLMP), 42 low-grade carcinomas (LG) and 57 high-grade carcinomas (HG).…”

Section: Patientsmentioning

confidence: 99%

Clinical significance of nuclear factor (NF)-κB levels in urothelial carcinoma of the urinary bladder

et al. 2008

View full text Add to dashboard Cite

Nuclear factor (NF)-kappaB has been reported to be constitutively activated in various human neoplasms. However, its clinical significance in bladder urothelial carcinoma (UC) remains an unresolved issue. We conducted this study trying to elucidate the role of NFkappaB in bladder UC and its potential prognostic significance, by quantifying immunohistochemically the levels of p65/RelA expression in paraffin-embedded tissue from 116 patients. Some of the cases had previously been stained for cellular FLICE-like inhibitory protein (c-FLIP) and bcl-2. Seventy-four cases displayed concurrent cytoplasmic and nuclear immunoreactivity, whereas 18 only nuclear immunoexpression and 21 only cytoplasmic immunoexpression, and the remaining three cases were negative for p65/RelA. Nuclear p65/RelA expression was positively associated with tumour grade and T-category (p=0.0001 in both cases). In addition, cytoplasmic p65/RelA expression was lower in advanced T-category (p=0.0030). Moreover, p65/RelA nuclear expression was positively correlated with c-FLIP (p=0.0109) and bcl-2 (p=0.0452). p65/RelA nuclear expression adversely affected survival in both univariate and multivariate analysis in superficial (Ta-T1; p=0.0010 and p=0.0008) as well as in muscle-invasive carcinomas (T2-T4; p=0.0004 and p=0.0003). Our results demonstrate that NF-kappaB nuclear expression is correlated with histologic grade and T category in bladder UC. Moreover, NF-kappaB nuclear expression emerges as an independent prognosticator of adverse significance, conveying information beyond that obtained by standard clinicopathological prognosticators.

show abstract

“…Registration of all patients with newly diagnosed bladder cancer has been done in some parts of Sweden since 1992, and in 1997 a national register covering all such patients was initiated [3,4], which includes patient-related variables (age, gender and domicile), tumour characteristics [tumour, node, metastasis (TNM) category and histopathology grade] and information about primary treatment performed within 3Á6 months. Information from this register can be used in population-based studies conducted on a national level [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Information from this register can be used in population-based studies conducted on a national level [3,4]. Previously published series from registration of muscle-invasive cancer treatment have shown that curative measures have been applied in 16Á41% of the cases [5Á7].…”

Section: Introductionmentioning

confidence: 99%

A population-based study of patterns of care for muscle-invasive bladder cancer in Sweden

Jahnson

Damm

Hellsten

et al. 2009

Scandinavian Journal of Urology and Nephrology

Self Cite

View full text Add to dashboard Cite

Lower rates of curative-intent treatment were found in patients registered at low-volume than at high-volume facilities, and the same was seen when comparing females with males, and patients aged 76-80 years with younger patients. Since many of these bladder cancer patients were registered at and eventually treated at hospitals handling fewer than 10 such cases annually, it seems desirable to concentrate treatment of this disease at more specialized centres.

show abstract

T1 G1 urinary bladder carcinoma: Fact or fiction?

Abstract: Well-differentiated urothelial carcinoma (G1) has no propensity to infiltrate the bladder mucosa. For investigating specific problems the data collected in the Swedish Urinary Bladder Cancer Registry have to be validated.

Cited by 28 publications

References 17 publications

D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance

D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance

Clinical significance of nuclear factor (NF)-κB levels in urothelial carcinoma of the urinary bladder

A population-based study of patterns of care for muscle-invasive bladder cancer in Sweden

Contact Info

Product

Resources

About