T1 and T2 weighted lesions and cognition in multiple Sclerosis: A systematic review and meta-analysis

Nabizadeh, Fardin; Pirahesh, Kasra; Azami, Mobin; Moradkhani, Asra; Sardaripour, Alireza; Ramezannezhad, Elham

doi:10.1016/j.jocn.2023.11.014

Cited by 2 publications

(1 citation statement)

References 75 publications

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“…4 Recent research has focused on whether specific patterns of brain dysmetabolism are associated with distinct AE syndromes, with the hope that these data could potentially differentiate AE subtypes before serological studies have resulted. [13][14][15][16] These investigations are aided by the development and application of quantitative methods to analyze brain 18 FDG-PET/CT data. Two commercially available brain mapping software programs, Cortex ID TM (GE Healthcare, Chicago, MI, USA) and NeuroQ TM (Syntermed, Atlanta, GA, USA) have been used for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Quantitative brain ¹⁸F‐FDG PET/CT analysis in seronegative autoimmune encephalitis

Roman,

Sadaghiani,

Diaz‐Arias

et al. 2024

Ann Clin Transl Neurol

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ObjectiveBrain 18F‐FDG PET/CT is a useful diagnostic in evaluating patients with suspected autoimmune encephalitis (AE). Specific patterns of brain dysmetabolism have been reported in anti‐NMDAR and anti‐LGI1 AE, and the degree of dysmetabolism may correlate with clinical functional status.18FDG‐PET/CT abnormalities have not yet been described in seronegative AE.MethodsWe conducted a cross‐sectional analysis of brain18FDG‐PET/CT data in people with seronegative AE treated at the Johns Hopkins Hospital. Utilizing NeuroQ™ software, the Z‐scores of 47 brain regions were calculated relative to healthy controls, then visually and statistically compared for probable and possible AE per clinical consensus diagnostic criteria to previous data from anti‐NMDAR and anti‐LGI1 cohorts.ResultsEight probable seronegative AE and nine possible seronegative AE were identified. The group only differed in frequency of abnormal brain MRI, which was seen in all of the probable seronegative AE patients. Both seronegative groups had similar overall patterns of brain dysmetabolism. A common pattern of frontal lobe hypometabolism and medial temporal lobe hypermetabolism was observed in patients with probable and possible seronegative AE, as well as anti‐NMDAR and anti‐LGI1 AE as part of their respective characteristic patterns of dysmetabolism. Four patients had multiple brain18FDG‐PET/CT scans, with changes in number and severity of abnormal brain regions mirroring clinical status.ConclusionsA18FDG‐PET/CT pattern of frontal lobe hypometabolism and medial temporal lobe hypermetabolism could represent a common potential biomarker of AE, which along with additional clinical data may facilitate earlier diagnosis and treatment.

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Section: Introductionmentioning

confidence: 99%

Quantitative brain ¹⁸F‐FDG PET/CT analysis in seronegative autoimmune encephalitis

Roman,

Sadaghiani,

Diaz‐Arias

et al. 2024

Ann Clin Transl Neurol

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Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

Jellinger

2024

J Neural Transm

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T1 and T2 weighted lesions and cognition in multiple Sclerosis: A systematic review and meta-analysis

Cited by 2 publications

References 75 publications

Quantitative brain ¹⁸F‐FDG PET/CT analysis in seronegative autoimmune encephalitis

Quantitative brain ¹⁸F‐FDG PET/CT analysis in seronegative autoimmune encephalitis

Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

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T1 and T2 weighted lesions and cognition in multiple Sclerosis: A systematic review and meta-analysis

Cited by 2 publications

References 75 publications

Quantitative brain 18F‐FDG PET/CT analysis in seronegative autoimmune encephalitis

Quantitative brain 18F‐FDG PET/CT analysis in seronegative autoimmune encephalitis

Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

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Resources

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Quantitative brain ¹⁸F‐FDG PET/CT analysis in seronegative autoimmune encephalitis

Quantitative brain ¹⁸F‐FDG PET/CT analysis in seronegative autoimmune encephalitis