T-type channels: release a brake, engage a gear

Weiss, Norbert; Lacinová, Ľubica

doi:10.1080/19336950.2015.1106655

Cited by 1 publication

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“…[37][38][39][40] Moreover, the cytoplasmic I-II loop, in addition to its role in modulating gating properties of T-type channels, 41,42 was shown to influence the trafficking of the channel to the cell surface. 43 29,30 There are different ways by which Stac1 may affect surface expression of hCa v 3.2 channels.…”

Section: Discussionmentioning

confidence: 99%

A Ca_v3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

et al. 2016

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Low-voltage-activated T-type calcium channels are essential contributors to neuronal physiology where they play complex yet fundamentally important roles in shaping intrinsic excitability of nerve cells and neurotransmission. Aberrant neuronal excitability caused by alteration of T-type channel expression has been linked to a number of neuronal disorders including epilepsy, sleep disturbance, autism, and painful chronic neuropathy. Hence, there is increased interest in identifying the cellular mechanisms and actors that underlie the trafficking of T-type channels in normal and pathological conditions. In the present study, we assessed the ability of Stac adaptor proteins to associate with and modulate surface expression of T-type channels. We report the existence of a Ca v 3.2/Stac1 molecular complex that relies on the binding of Stac1 to the amino-terminal region of the channel. This interaction potently modulates expression of the channel protein at the cell surface resulting in an increased T-type conductance. Altogether, our data establish Stac1 as an important modulator of T-type channel expression and provide new insights into the molecular mechanisms underlying the trafficking of T-type channels to the plasma membrane.

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Section: Discussionmentioning

confidence: 99%

A Ca_v3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

et al. 2016

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T-type channels: release a brake, engage a gear

Cited by 1 publication

References 8 publications

A Ca_v3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

A Ca_v3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

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T-type channels: release a brake, engage a gear

Cited by 1 publication

References 8 publications

A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

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A Ca_v3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane

A Ca_v3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane