T<sub>H</sub>1‐TYPE IMMUNE RESPONSE IN LYMPHOCYTE‐PREDOMINANCE HODGKIN'S DISEASE

Dargent, Jean‐Louis; Schandené, Liliane; Kornreich, Anne; Jagodzinski, Robert; Capel, Paul D.; Velu, Thierry; Nève, Pierre

doi:10.1111/j.1365-2141.1995.tb05388.x

Cited by 5 publications

(3 citation statements)

References 3 publications

(2 reference statements)

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“…T cell mediated immune response against the tumor cells, tumor antigen stimulation causing fibrosis followed by granuloma formation and delayed hypersensitivity to decomposition products of the tumor cells are some of the considered theories. 6 , 7 , 8 …”

Section: Discussionmentioning

confidence: 99%

Necrotising granulomas masking Hodgkin lymphoma: Report of a rare case

Kunnumbrath

Chandra

Azad

et al. 2023

Hematology, Transfusion and Cell Therapy

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Section: Discussionmentioning

confidence: 99%

Necrotising granulomas masking Hodgkin lymphoma: Report of a rare case

Kunnumbrath

Chandra

Azad

et al. 2023

Hematology, Transfusion and Cell Therapy

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“…Our case highlights the Richter transformation of CLL to HL, which is reported to occur in about 0.4% of cases of CLL. Although DLBCL is the most common form of RT of CLL, hairy cell leukemia, lymphoblastic lymphoma, and high-grade T-cell and NSHL have also been documented [ 4 , 12 ]. Due to the aggressive nature of RT Hodgkin lymphoma, treatment options are limited, but the signs that transformation has occurred may not be obvious.…”

Section: Discussionmentioning

confidence: 99%

“…A recently published case report also describes extensive granulomatous reaction masking the CD30/CD15-positive RS cells in the cervical lymph node of a young male [ 11 ]. The exact etiology of a background granulomatous process in HL is unknown, but a few studies suggest the role of T cell-mediated nonspecific inflammatory response especially neoplastic cells induced T-helper cell-mediated immune response as well as delayed hypersensitivity reaction in conjunction with cytokines against antigen produced by neo-plastic cells, which subsequently result in fibrosis and granuloma formation [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Rare Richter Transformation of Chronic Lymphocytic Lymphoma to Hodgkin Lymphoma

et al. 2021

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Patient: Female, 68-year-old Final Diagnosis: Richter transformation of CLL to HL Symptoms: Abdominal pain • ascites • diffuse lymphadenopathy • fever • hepatosplenomegaly • pleural effusion • weakness Medication: — Clinical Procedure: — Specialty: Forensic Medicine • Hematology • General and Internal Medicine • Oncology • Pathology Objective: Rare disease Background: Richter transformation (RT) is an uncommon clinicopathological condition referring to the development of aggressive lymphoma from chronic lymphocytic lymphoma/small lymphocytic lymphoma (CLL/SLL) and characterized by sudden clinical deterioration with marked multifocal lymphadenopathy. Transformation of CLL/SLL to diffuse large B-cell lymphoma is the most common (2–9%), but T-cell and Hodgkin transformation (HL) (0.4%) occur, although less frequently. Case Report: A 68-year-old woman initially diagnosed with CLL/SLL presented to the hospital with fever, weakness, abdominal pain, and vomiting. The physical examination showed hepatosplenomegaly and extensive abdominal lymphadenopathy on radiological imaging. The laboratory work-up revealed pancytopenia and a markedly increased alkaline phosphatase. In the setting of extensive granulomatous hepatitis, the development of aggressive Hodgkin lymphoma Richter transformation with multi-organ involvement within a few months led to the patient’s sudden death. Autopsy findings led to the post-mortem diagnosis of Richter transformation of CLL. Conclusions: Here, we describe a rare case of Hodgkin lymphoma RT from progressive CLL, with transformation occurring at approximately 12 years after initial diagnosis, despite treatment. Our case report underscores the diagnostic challenges and pitfalls associated with the granulomatous presentation masking RT transformation of CLL to Hodgkin lymphoma. The purpose of this report is to raise suspicion for the clinicopathological signs of Richter transformation in the presence of an atypical granulomatous presentation.

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