T<sub>4</sub>-T<sub>3</sub>Shift during the Postprandial Period After Glucose Load in Obese Children before and after Hypocaloric Diet - One Factor for Postprandial Thermogenesis?

Hesse, V.; Spahn, U; Plenert, W

doi:10.1055/s-2007-1019160

Cited by 4 publications

(3 citation statements)

References 8 publications

(10 reference statements)

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“…Previously, oral and intravenous glucose loads induced T4 reduction and slightly increased T3-levels postprandially in overweight children. 54 Conversely, a hypocaloric intervention (600-1000 kcal per day) for 21 days reduced T3 while increas- ing T4 concentrations after an oral glucose load. 54 In the current study we showed that a WWB meal challenge containing 50 g available CHO, irrespective of BPB consumption, could potentially affect postprandial thyroid hormones in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

“…54 Conversely, a hypocaloric intervention (600-1000 kcal per day) for 21 days reduced T3 while increas- ing T4 concentrations after an oral glucose load. 54 In the current study we showed that a WWB meal challenge containing 50 g available CHO, irrespective of BPB consumption, could potentially affect postprandial thyroid hormones in healthy subjects. While the effect of BPB on T3 was observed as a time effect, the multivariate analysis showed that subjects with BPB (indicated as a blue dot; Fig.…”

Section: Discussionmentioning

confidence: 99%

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Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects

et al. 2018

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Pleiotropic effects of spices on health, particularly on glucose metabolism and energy regulation, deserve further clinical investigation into their efficacy. The aim of the current study was to evaluate whether consumption of a black pepper-based beverage (BPB) preload containing 20 mg gallic acid equivalent (GAE) would exert any effect on postprandial glycaemia, appetite sensations, gut hormones, thyroid function, and gastrointestinal well-being after a white wheat bread (WWB) challenge meal containing 50 g available carbohydrates (CHO) compared to a control beverage. Sixteen healthy subjects (10 men; 6 women; 26 ± 0.9 years; BMI 22.93 ± 0.53 kg m-2) completed a randomized, crossover intervention study. The BPB's bioactive compounds were characterized using ultra high-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer with an electrospray ionization source (UHPLC-DAD-ESI-QTOF-MS). Nine compounds tentatively identified in BPB include: dihydroxybenzoic acid hexoside-pentoside, decaffeoyl-acteoside, cynaroside A, apigenin 6,8-di-C-hexoside, luteolin 6-C-hexoside-8-C-rhamnoside, apigenin 8-C-hexoside-C-deoxyhexoside, kaempferol 3-rhamnoside-4'-xyloside, apigenin 7-neohesperidoside, and apigenin-8-C-arabinopyranoside-2''-rhamnoside. Blood glucose and serum insulin responses, insulin sensitivity and β-cell function were not affected during the acute intervention with BPB. Neither were effects on gastrointestinal well-being observed after BPB. However, BPB modulated overall acute appetite by lowering 'hunger', 'desire to eat', and 'prospective consumption', and increasing 'satiety' and 'fullness'. In contrast, there were no changes in gut (peptide tyrosine-tyrosine [PYY] and glucagon-like peptide-1 [GLP-1]) and thyroid (triiodothyronine [T3] and thyroxine [T4]) hormones after BPB compared to the control beverage. In conclusion, inclusion of BPB prior to the WWB challenge meal might be beneficial for appetite modulation, but we did not find supporting evidence in glycaemia, gut and thyroid hormones. Further studies are needed to elucidate the mechanisms of appetite-reducing pungent spices, such as black pepper.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects

et al. 2018

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“…Such exces-sive wastage is usually attributed to the brown adipose tissue in rodents; this phenomenon is called dietary-or meal-induced thermogenesis (Rothwell & Stock, 1979). In humans, the causal mechanism for the phenomenon is not as well understood, although changes in the efficiency of thyroid hormone may play a role (Hesse, Spahn, & Pienert, 1981).…”

Section: The Problem Of Satietymentioning

confidence: 99%

The eating paradox: How we tolerate food.

Woods

1991

Psychological Review

300

258

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It is hypothesized that food, which is certainly a necessary commodity with powerful positive reinforcing qualities, also provides a potential threat to organisms, including humans. The act of eating, although necessary for the provision of energy, is a particularly disruptive event in a homeostatic sense. Just as humans learn responses to help them tolerate the administration of dangerous drugs, so do they learn to make anticipatory responses that help minimize the impact of meals on the body, to limit the amount of food consumed within any individual meal, to recruit several parts of the protective stress-response system while meals are being processed, and to limit postprandial behaviors so as to minimize the possibility of disrupting homeostatic systems even more. It is further hypothesized that defenses against eating too much may become activated inappropriately and contribute to clinical problems such as reactive hypoglycemia.

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Pharmacology of Thermogenesis

Stribling¹

1983

Mammalian Thermogenesis

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T₄-T₃Shift during the Postprandial Period After Glucose Load in Obese Children before and after Hypocaloric Diet - One Factor for Postprandial Thermogenesis?

Abstract: Reactions of the plasma concentrations of the thermogenetically active thyroid hormones T 3 and T 4 were studied in overweight children during the postprandial period after glucose load before and after feeding a hypocaloric diet.

Cited by 4 publications

References 8 publications

Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects

Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects

The eating paradox: How we tolerate food.

Pharmacology of Thermogenesis

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T4-T3Shift during the Postprandial Period After Glucose Load in Obese Children before and after Hypocaloric Diet - One Factor for Postprandial Thermogenesis?

Abstract: Reactions of the plasma concentrations of the thermogenetically active thyroid hormones T 3 and T 4 were studied in overweight children during the postprandial period after glucose load before and after feeding a hypocaloric diet.

Cited by 4 publications

References 8 publications

Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects

Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects

The eating paradox: How we tolerate food.

Pharmacology of Thermogenesis

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Product

Resources

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T₄-T₃Shift during the Postprandial Period After Glucose Load in Obese Children before and after Hypocaloric Diet - One Factor for Postprandial Thermogenesis?