T<sub>2</sub>*-correction in dynamic contrast-enhanced MRI from double-echo acquisitions

Kleppestø, Magne; Larsson, Christopher; Groote, Inge Rasmus; Salo, Raimo A.; Vardal, Jonas; Courivaud, Frédéric; Bjørnerud, Alte

doi:10.1002/jmri.24268

Cited by 32 publications

(34 citation statements)

References 24 publications

(23 reference statements)

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“…This demonstrates that T 2 * correction of the muscle signal results in a substantial increase in the estimated AIF. A similar effect has been seen when T 2 * correction is applied directly to the plasma signal [6]. Figure 1f shows example model fits to the T 2 * corrected and uncorrected LTIC.…”

Section: Resultssupporting

confidence: 65%

“…The influence of T 2 * effect on lesion signal intensity and AIF can induce systematic errors in contrast kinetic parameter estimation as previous studies [6,17–20] showed. However, it has not been shown that T 2 * effect on contrast kinetic parameter estimation when a reference tissue approach is used where direct measurement of AIF is not feasible.…”

Section: Discussionmentioning

confidence: 92%

“…When the T 2 * effect is negligible, the conversion of time-intensity curves to time-concentration curves is simplified as the signal enhancement depends only on changes in T 1 induced by contrast agent concentration. However, a recent study [6] has demonstrated that the T 2 * effect may not be negligible in practice.…”

Section: Introductionmentioning

confidence: 99%

“…It has also been recently shown that, even at 3T, which is widely used for routine clinical imaging, the effect of T 2 * cannot be ignored [6]. An arterial input function (AIF) measured from a major vessel could be substantially underestimated due to larger T 2 * effects from higher concentrations of contrast agent.…”

Section: Introductionmentioning

confidence: 99%

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Effect of $$ T_{2}^{*} $$ correction on contrast kinetic model analysis using a reference tissue arterial input function at 7 T

Jin

Freed

Winters

et al. 2015

Magn Reson Mater Phy

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Object To investigate the effect of T2* correction on estimation of kinetic parameters from T1-weighted dynamic contrast enhanced (DCE) MRI data when a reference-tissue arterial input function (AIF) is used. Materials and Methods DCE-MRI data were acquired from 7 mice with 4T1 mouse mammary tumors using a double gradient echo sequence at 7T. The AIF was estimated from a region of interest in the muscle. The extended Tofts model was used to estimate pharmacokinetic parameters in the enhancing part of the tumor, with and without T2* correction of the lesion and AIF. The parameters estimated with T2* correction of both the AIF and lesion time-intensity curve were assumed to be the reference standard. Results For the whole population, there was significant difference (p<0.05) in transfer constant (Ktrans) between T2* corrected and not corrected methods, but not in interstitial volume fraction (ve). Individually, no significant differences were found in Ktrans and ve of four and six tumors, respectively, between the T2* corrected and not corrected methods. In contrast, Ktrans was significantly underestimated, if the T2* correction was not used, in other tumors of which median Ktrans was larger than 0.4 min−1. Conclusion T2* effect on tumors with high Ktrans may not be negligible in kinetic model analysis, even if AIF is estimated from reference tissue where the concentration of contrast agent is relatively low.

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Section: Resultssupporting

confidence: 65%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of $$ T_{2}^{*} $$ correction on contrast kinetic model analysis using a reference tissue arterial input function at 7 T

Jin

Freed

Winters

et al. 2015

Magn Reson Mater Phy

View full text Add to dashboard Cite

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“…This approach has recently been shown to reduce errors in DCEderived parameters. 35 While this study suggests that DCE-and DSC-MRI data acquired by a multi-echo sequence may aid the diagnostics of N-status in rectal cancer patients, several potential study limitations needs to be addressed. First, the results must be interpreted in light of the limited sample size of this single center study.…”

Section: Grøvik Et Al: Dce-and Dsc-mri Of Rectal Cancermentioning

confidence: 91%

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis

Grøvik

Redalen

Storås

et al. 2016

J. Magn. Reson. Imaging

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Purpose: To implement a dynamic contrast-based multi-echo MRI sequence in assessment of rectal cancer and evaluate associations between histopathologic data and the acquired dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) -MRI parameters. Materials and Methods: This pilot study reports results from 17 patients with resectable rectal cancer. Dynamic contrast-based multi-echo MRI (1.5T) was acquired using a three-dimensional multi-shot EPI sequence, yielding both DCE-and DSC-data following a single injection of contrast agent. The Institutional Review Board approved the study and all patients provided written informed consent. Quantitative analysis was performed by pharmacokinetic modeling on DCE data and tracer kinetic modeling on DSC data. Mann-Whitney U-test and receiver operating characteristics curve statistics was used to evaluate associations between histopathologic data and the acquired DCE-and DSC-MRI parameters. Results: For patients with histologically confirmed nodal metastasis, the primary tumor demonstrated a significantly lower K trans and peak change in R Ã 2 , R Ã 2 -peak enh , than patients without nodal metastasis, showing a P-value of 0.010 and 0.005 for reader 1, and 0.043 and 0.019 for reader 2, respectively. Conclusion: This study shows the feasibility of acquiring DCE-and DSC-MRI in rectal cancer by dynamic multi-echo MRI. A significant association was found between both K trans and R Ã 2 -peak enh in the primary tumor and histological nodal status of the surgical specimen, which may improve stratification of patients to intensified multimodal treatment.

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Temporal resolution improvement of calibration‐free dynamic contrast‐enhanced MRI with compressed sensing optimized turbo spin echo: The effects of replacing turbo factor with compressed sensing accelerations

Han

Cho

2015

Magnetic Resonance Imaging

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Purpose: To enhance the temporal resolution of calibration-free dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) by implementing compressed sensing assisted turbo spin echo (CS-TSE) acquisition. Materials and Methods: The dynamic sparse sampling variables including acceleration factor, randomized phase encoding distributions, and reconstruction constraints were retrospectively optimized by minimizing the difference from fully sampled dynamic TSE at 7T. The degree of contrast enhancement and the calibration-free quantification of gadolinium (Gd) concentration were evaluated among fast low-angle shot (FLASH), TSE, and CS-TSE acquisitions with multiple phantoms (0.1-6 mM). The kidney-feeding in vivo arterial input function (AIF) was measured at multiple administration doses (0.1-0.3 mmol/kg) to evaluate the benefit of CS-TSE for quantifying rapidly changing high Gd concentrations in C57BL/6 mice (n 5 22). Results: In phantom studies, both calibration-free and calibrated conversions estimated equivalent Gd concentrations for CS-TSE (scatterplot slope 5 0.9801, r 2 5 0.9998, P < 0.001). In in vivo studies, 4-fold higher temporal resolution (0.96 sec) of CS-TSE over the corresponding TSE enabled robust measurement of AIF first-pass peak and resulting peak enhancement with CS-TSE were observed, with 1.1439-and 2.1258-fold times higher than those with TSE and FLASH acquisitions, respectively, at the 0.1 mmol/kg dose. Calibration-free estimates of AIF peak concentration with CS-TSE were in good agreement with the calibrated approach at multiple administration doses (scatterplot slope 5 0.7800, r 2 5 0.8014, P < 0.001). Conclusion: Temporal resolution-improved CS-TSE provides practical subsecond (0.96s) calibration-free dynamic MR quantification of high Gd concentration.

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T₂*-correction in dynamic contrast-enhanced MRI from double-echo acquisitions

Abstract: In DCE, a sufficiently short echo time should be used or corrections for T2*-effects based on double-echo acquisition should be made for correct quantification of kinetic parameters.

Cited by 32 publications

References 24 publications

Effect of $$ T_{2}^{*} $$ correction on contrast kinetic model analysis using a reference tissue arterial input function at 7 T

Effect of $$ T_{2}^{*} $$ correction on contrast kinetic model analysis using a reference tissue arterial input function at 7 T

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis

Temporal resolution improvement of calibration‐free dynamic contrast‐enhanced MRI with compressed sensing optimized turbo spin echo: The effects of replacing turbo factor with compressed sensing accelerations

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T2*-correction in dynamic contrast-enhanced MRI from double-echo acquisitions

Abstract: In DCE, a sufficiently short echo time should be used or corrections for T2*-effects based on double-echo acquisition should be made for correct quantification of kinetic parameters.

Cited by 32 publications

References 24 publications

Effect of $$ T_{2}^{*} $$ correction on contrast kinetic model analysis using a reference tissue arterial input function at 7 T

Effect of $$ T_{2}^{*} $$ correction on contrast kinetic model analysis using a reference tissue arterial input function at 7 T

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor Ktrans and ΔR2* peak are significantly associated with lymph node metastasis

Temporal resolution improvement of calibration‐free dynamic contrast‐enhanced MRI with compressed sensing optimized turbo spin echo: The effects of replacing turbo factor with compressed sensing accelerations

Contact Info

Product

Resources

About

T₂*-correction in dynamic contrast-enhanced MRI from double-echo acquisitions

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis