{T, S} Splittings of Rectangular Matrices Revisited

Reddy, K. Appi; Kurmayya, T.

doi:10.12732/ijpam.v108i4.16

Cited by 1 publication

(2 citation statements)

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“…In contrast to early time points, by 24 h, abundant TRITC positive cells were detected in the cortex of LNs (Figure b, right panel). The kinetics observed were consistent with SPIO possessing the optimal physical properties required for lymphatic‐specific uptake and subsequent transport via lymph flow to LN …”

Section: Resultssupporting

confidence: 70%

“…The size and properties of particles can determine the rate at which they transit by mechanical means to LNs, ranging from seconds to a day, with optimal transport via lymphatics achieved in particles between 20 and 60 nm in diameter. By contrast, cellular transport via loaded antigen‐presenting cells takes from 2 to 24 h to traffic from the peripheral tissue to the LN, and subsequent retention of particulates in the LNs depends on size and retention by phagocytic cells …”

Section: Introductionmentioning

confidence: 99%

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Impact of Locally Administered Carboxydextran‐Coated Super‐Paramagnetic Iron Nanoparticles on Cellular Immune Function

Pedro

Harmer

Mayes

et al. 2019

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Interstitially-administered iron oxide particles are currently used for inter-operative localization of sentinel lymph nodes (SLNs) in cancer staging. Several studies have described concerns regarding the cellular accumulation of iron oxide nanoparticles relating them to phenotype and function deregulation of macrophages, impairing their ability to mount an appropriate immune response once an insult is present. This study aimed to address what phenotypic and functional changes occur during lymphatic transit and accumulation of these particles. Data shows that 60 nm carboxydextran-coated iron nanoparticles use a non-cellular mechanism to reach the draining LN and that their accumulation in macrophages induces transient phenotypic and functional changes. Nevertheless, macrophages recover their baseline levels of response within 7 days, and are still able to mount an appropriate response to bacterially-induced inflammation.

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Section: Resultssupporting

confidence: 70%