T regulatory markers expression in unexplained recurrent spontaneous abortion

Saifi, Bita; Aflatoonian, Reza; Tajik, Nader; Ahmadpour, M; Vakili, Rosita; Amjadi, Fatemehsadat; Valizade, Narges; Ahmadi, Sanaz; Rezaee, Seyed Abdolrahim; Mehdizadeh, Mehdi

doi:10.3109/14767058.2015.1039507

Cited by 16 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, expressions of Th17‐related cytokines and transcription factor, such as IL‐17, IL‐23, and RORγt, were significantly increased in the decidua of RPL patients . Meanwhile, expressions of Treg‐cell‐related cytokines and transcription factor, such as IL‐10, TGF‐β, and Foxp3, were significantly downregulated . Hence, the excessive Th17 cells or deficiency of Treg cells may induce spontaneous abortion, while the balance between these two cells is beneficial to pregnancy .…”

Section: Introductionmentioning

confidence: 99%

IL‐7/IL‐7R signaling pathway might play a role in recurrent pregnancy losses by increasing inflammatory Th17 cells and decreasing Treg cells

et al. 2016

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

IL‐7/IL‐7R signaling pathway might play a role in recurrent pregnancy losses by increasing inflammatory Th17 cells and decreasing Treg cells

et al. 2016

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…Tolerance is a specific immunological term that refers to “the active state of antigen‐specific non‐responsiveness” leading to diminished reactivity to paternal antigens expressed by the placenta and/or fetus; it is considered key for successful pregnancy . The mechanisms responsible for tolerance in pregnancy include the following: (i) T‐cell chemokine gene silencing in the decidual cells; (ii) a suppressive role of regulatory T cells; (iii) expression of non‐classical major histocompatibility complex molecules on trophoblast cells that do not elicit a maternal immune response; (iv) changes in tryptophan catabolisms; (v) T‐cell apoptosis; (vi) complement; and (vii) costimulatory molecules such as the programmed death ligand . Other mechanisms for tolerance are not currently understood.…”

Section: Introductionmentioning

confidence: 99%

CXCL10 and IL‐6: Markers of two different forms of intra‐amniotic inflammation in preterm labor

Romero

Chaemsaithong

Chaiyasit

et al. 2017

American J Rep Immunol

View full text Add to dashboard Cite

ProblemTo determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM).Method of StudyThis study included 168 women who had an episode of PTL or preterm PROM. AF interleukin (IL)‐6 and CXCL10 concentrations were determined by immunoassay.Results(i) Increased AF CXCL10 concentration was associated with chronic (OR: 4.8; 95% CI: 1.7‐14), but not acute chorioamnionitis; (ii) increased AF IL‐6 concentration was associated with acute (OR: 4.2; 95% CI: 1.3‐13.7) but not chronic chorioamnionitis; and (iii) an increase in AF CXCL10 concentration was associated with placental lesions consistent with maternal anti‐fetal rejection (OR: 3.7; 95% CI: 1.3‐10.4). (iv) All patients with elevated AF CXCL10 and IL‐6 delivered preterm.ConclusionIncreased AF CXCL10 concentration is associated with chronic chorioamnionitis or maternal anti‐fetal rejection, whereas increased AF IL‐6 concentration is associated with acute histologic chorioamnionitis.

show abstract

“…High level expression of GITR after activation of CD8 + Tregs is essential for costimulation of CD8 + T cells, because the lack of GITR will reduce the proliferation response of these cells to costimulation of CD28 [21]. The expression of GITR was decreased in repeated implantation failure (RIF) or unexplained RPL [55,56], which indicates that GITR may play critical roles in regulating the immune response during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

The Fluctuation of Regulatory T Cells during Pregnancy and Obstetrical Complications

Zhao

Bao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Regulatory T cells (Tregs) are critical immunomodulators during pregnancy by preventing maternal T-cell activation against fetal cells. However, how characteristics of maternal Tregs vary during pregnancy is still unclear. We analyzed the proportion and phenotypic characteristics of peripheral blood Tregs in normal pregnant women, women with recurrent pregnancy loss (RPL) or gestational diabetes mellitus (GDM), and non-pregnant women.Methods: We investigated the proportion of CD4+ Tregs, CD8+ Tregs and the expression of PD-1, GITR, HLA-G and CTLA-4 on them in the peripheral blood of normal pregnancies during 1st (n = 28), 2nd (n = 43), and 3rd trimester (n = 33); In addition, we evaluated pregnancies in the 1st trimester complicated by RPL (n = 21), in the 2nd (n = 17) and 3rd trimester (n = 28) complicated by GDM. Non-pregnant women (n = 57) were also investigated using flow cytometry.Results: During normal pregnancy, the proportion of CD4+ Tregs in all trimester and CD8+ Tregs in 2nd and 3rd trimester were higher(P ＜ 0.05，respectively) compared with non-pregnancy women. Moreover, the proportion of CD4+ Tregs was higher in 2nd trimester compared to 1st and 3rd trimester (P ＜ 0.01) while the proportion of CD8+ Tregs was higher in 3rd trimester compared to 1st and 2nd trimester (P ＜ 0.05). Compared to non-pregnant studies, the proportion of GITR+/CD8+ Tregs and HLA-G+/CD8+ Tregs in all trimester were higher(P ＜ 0.05, respectively). Moreover, the proportion of PD-1+/CD4+ Tregs, GITR+/CD4+ Tregs, PD-1+/CD8+ Tregs and CTLA-4+/CD8+ Tregs in 3rd trimester were significantly higher compared to 1st, 2nd trimester and non-pregnant group(P ＜ 0.05, respectively).In RPL and GDM groups, the proportions of CD4+ Tregs in all trimesters were decreased while the proportions of CD8+ Tregs in all trimesters were increased compared to normal pregnant group (P ＜ 0.05，respectively).In RPL group, the proportion of PD-1+/CD4+ Tregs, GITR+/CD4+ Tregs and HLA-G+/CD4+ Tregs were decreased compared to 1st trimester normal pregnant group (P ＜ 0.05，respectively). In 2nd trimester GDM group, the proportion of HLA-G+/CD4+ Tregs were decreased compared to 2nd trimester normal pregnant group (P ＜ 0.05，respectively). In 3rd trimester GDM group, the proportion of PD-1+/CD4+ Tregs, GITR+/CD4+ Tregs, PD-1+/CD8+ Tregs, GITR+/CD8+ Tregs and HLA-G+/CD8+Tregs were decreased compared to 3rd trimester normal pregnant group (P ＜ 0.05, respectively).Conclusions: The proportion of CD4+ Tregs and CD8+ Tregs increased during pregnancy, the proportions and subsets of CD4+ Tregs decreased and those of CD8+ Tregs increased in pregnancies complicated by RPL and GDM, indicating that regulatory T cells play a role in pregnancy maintenance, and the abnormal expression of Tregs might be related to the complicated pregnancy.

show abstract

T regulatory markers expression in unexplained recurrent spontaneous abortion

Cited by 16 publications

References 27 publications

IL‐7/IL‐7R signaling pathway might play a role in recurrent pregnancy losses by increasing inflammatory Th17 cells and decreasing Treg cells

IL‐7/IL‐7R signaling pathway might play a role in recurrent pregnancy losses by increasing inflammatory Th17 cells and decreasing Treg cells

CXCL10 and IL‐6: Markers of two different forms of intra‐amniotic inflammation in preterm labor

The Fluctuation of Regulatory T Cells during Pregnancy and Obstetrical Complications

Contact Info

Product

Resources

About