T-Peak to T-End Improvements After Beta-Blocker Administration in Peripartum Cardiomyopathy Patients

Achmad, Chaerul; Iqbal, Mohammad; Karwiky, Giky; Prameswari, Hawani Sasmaya; Febrianora, Mega

doi:10.14740/cr1053

Cited by 3 publications

(3 citation statements)

References 31 publications

(37 reference statements)

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“…Forty‐seven studies, comprising 4875 patients across 60 countries, were considered eligible and were included in the systematic review ( Table 1 ). 1,15–65 A list of excluded studies, with reasons for exclusion, is provided in online supplementary Table .…”

Section: Resultsmentioning

confidence: 99%

A global perspective on the management and outcomes of peripartum cardiomyopathy: a systematic review and meta‐analysis

Hoevelmann

Engel

Muller

et al. 2022

European J of Heart Fail

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Peripartum cardiomyopathy (PPCM) remains a major contributor to maternal morbidity and mortality worldwide. The disease is associated with various complications occurring mainly early during its course. Reported adverse outcomes include decompensated heart failure, thromboembolic complications, arrhythmias and death. We sought to systematically and comprehensively review published literature on the management and outcome of women with PPCM across different geographical regions and to identify possible predictors of adverse outcomes.

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Section: Resultsmentioning

confidence: 99%

A global perspective on the management and outcomes of peripartum cardiomyopathy: a systematic review and meta‐analysis

Hoevelmann

Engel

Muller

et al. 2022

European J of Heart Fail

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“…The anti-remodeling drugs effects on Tpe interval and time to peak longitudinal strain could be considered as the cause of this weak correlation. However, the studies of anti-remodeling drugs effects on Tpe interval and time to peak longitudinal strain were limited [14,15].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between T Peak to End Interval and Left Ventricular Time to Peak Longitudinal Strain in Ischemic Cardiomyopathy Patients

et al. 2020

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Background: Ischemic cardiomyopathy is the most frequent etiology of heart failure with reduced ejection fraction (HFrEF) and a result of ventricular structural, functional and electrical remodeling. T peak to end (Tpe) interval is an electrocardiographic parameter that represents repolarization heterogeneity and had prognostic value for ventricular arrhythmia. Patients with ischemic cardiomyopathy face a significant burden of arrhythmias. Mechanical dispersion is a functional remodeling parameter that can be measured by time to peak longitudinal strain using speckle tracking echocardiography. This study aimed to assess the relationship between Tpe interval with time to peak longitudinal strain in ischemic cardiomyopathy patients. Methods: This study was conducted with an observational analytical cross-sectional design. Ischemic cardiomyopathy subjects were included at Dr. Hasan Sadikin General Hospital, Bandung, from August to October 2019. Tpe interval was measured manually with the tangential method. Time to peak longitudinal strain was measured using speckle tracking echocardiography. The correlation between Tpe interval and time to peak longitudinal strain was analyzed using Pearson correlation. Results: A total of 30 subjects were included in this study. The average age was 58 ± 8 years old, and the average left ventricular ejection fraction was 27±5.5%. The average of Tpe interval was 83.4 ± 7.62 ms, and the average time to peak longitudinal strain was 93.13 ± 34.51 ms. The Pearson correlation test showed a significant weak positive correlation (r = 0.386, 95% confidence interval: 0.029-0.743, P = 0.018) between Tpe interval and time to peak longitudinal strain in ischemic cardiomyopathy patients. Conlucions: There was a significant weak positive correlation between Tpe interval and time to peak longitudinal strain in ischemic cardiomyopathy patients.

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“…The assessment of the duration of electrocardiographic parameters of the repolarization period: QT, TpTe (Tpeak-Tend) in a group of women during pregnancy and puerperium, may prove to be diagnostically useful in the early detection of arrhythmias and in the assessment of the increased risk of arrhythmogenesis. Early identification of risk groups will enable the implementation of therapeutic and preventive measures along with a change in lifestyle and pharmacotherapy [12].…”

Section: Introductionmentioning

confidence: 99%

Tpeak-Tend Interval during Pregnancy and Postpartum

Kandzia

Markiewicz-Łoskot

Binkiewicz³

2022

IJERPH

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Background: Pregnancy is a condition in which new cardiac arrhythmias can occur or prior undiagnosed arrhythmias may provide symptoms. The occurrence of severe ventricular arrhythmias and polymorphic ventricular tachycardia that may lead to fainting or sudden cardiac death is promoted by the prolongation of the QTc interval. The post-partum adaptation period is the most arrhythmogenic. TpTe (Tpeak-Tend interval) is a novel marker of arrhythmogenesis by many considered a more sensitive marker than QTc. Objective: The aim of our work was to determine the TpTe interval (Tpeak-Tend) in women in the first, second and third trimester of pregnancy and the post-partum period. Materials and Methods: The study group consisted of 128 women in pregnancy or postpartum and a control group of 32 non-pregnant women. A standard 12-lead ECG (electrocardiograph) recording with evaluation of the duration of TpTe and QTc was performed in all patients. Results: In comparison to the non-pregnant women, higher values of QTc and TpTe were observed starting in the first trimester with highest values observed in the postpartum period. Mean duration of TpTe interval during pregnancy (81.59 ± 5.92 ms) and in the whole study group (pregnancy + postpartum) (85.46 ± 6.45 ms) was significantly longer (p < 0.001) compared to the TpTe interval in the control group (74.06 ± 6.14 ms). During pregnancy and postpartum, the increase in the TpTe interval in comparison to the increase in the QTc parameter (31.10% vs. 4.18%) was significantly higher (p < 0.001). Conclusions: The study showed an increase in the duration of the TpTe interval and QTc parameter during pregnancy and postpartum with the highest values in the postpartum period. TpTe interval increase was significantly higher compared to QTc increase during pregnancy and postpartum. Changes of TpTe interval were not associated with any clinical outcome or measure of arrythmia burden. Further studies are needed in order to see the clinical significance of these ECG findings, in particular for larger groups of patients with automatic measurement in correlation with echocardiography

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T-Peak to T-End Improvements After Beta-Blocker Administration in Peripartum Cardiomyopathy Patients

Cited by 3 publications

References 31 publications

A global perspective on the management and outcomes of peripartum cardiomyopathy: a systematic review and meta‐analysis

A global perspective on the management and outcomes of peripartum cardiomyopathy: a systematic review and meta‐analysis

Correlation Between T Peak to End Interval and Left Ventricular Time to Peak Longitudinal Strain in Ischemic Cardiomyopathy Patients

Tpeak-Tend Interval during Pregnancy and Postpartum

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