t-PA activity in peripheral blood obtained from pregnant women

Ishii, Akiharu; Yamada, Seiichi; Yamada, Ritsuko; Hamada, Hiroshi

doi:10.1515/jpme.1994.22.2.113

Cited by 26 publications

(10 citation statements)

References 5 publications

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“…t-PA activity decreased during pregnancy as previously described (24). This is partly an effect of the increased production of PAI-1 and PAI-2 in the placenta and the endothelium, respectively.…”

Section: Discussionsupporting

confidence: 81%

APC Resistance and other Haemostatic Variables during Pregnancy and Puerperium

Kjellberg

Andersson²,

Rosén³

et al. 1999

Thromb Haemost

155

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SummaryForty-eight healthy pregnant women were studied prospectively and longitudinally. Blood sampling was performed at 10-15, 23-25, 32-34 and 38-40 weeks of gestation, within one week and at eight weeks postpartum. Classic and modified activated protein C ratio decreased as pregnancy progressed. In the third trimester 92% of the ratios measured with the classic test were above the lower reference level whereas all modified test ratios were normal. Slight activation of blood coagulation was shown with increased levels of prothrombin fragment 1+2, soluble fibrin and D-dimer. Fibrinogen, factor VIII and plasminogen activator inhibitor type 1 and type 2 increased. Protein S and tissue plasminogen activator activity decreased. Protein C remained unchanged. No correlation was found between the decrease in classic APC ratio and changes in factor VIII, fibrinogen, protein S, prothrombin fragment 1+2 or soluble fibrin, nor between the increase in soluble fibrin and changes in prothrombin fragment 1+2, fibrinogen and D-dimer.

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Section: Discussionsupporting

confidence: 81%

APC Resistance and other Haemostatic Variables during Pregnancy and Puerperium

Kjellberg

Andersson²,

Rosén³

et al. 1999

Thromb Haemost

155

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“…In contrast to our obtained data, in earlier published studies, the decrease of t-PA activity in blood plasma during pregnancy was determined [70] and later publications report about the moderate increase of this parameter in pregnant women without any marked pathologies [76,77]. It should be noted that the decrease of t-PA level and activity is connected with an increased risk of thrombosis [78], as well as with intrauterine growth retardation and preeclampsia [79].…”

Section: Partcontrasting

confidence: 95%

“…These statements are based on the fact-finding of prolongation of clot lysis time of fibrin that was collected from blood plasma [67,68], the decrease of t-PA concentration, as well as on the increase of PAI-1 and PAI-2 levels [61,69,70]. Some authors presuppose that the observed changes earlier viewed activators and inhibitors do not influence the general fibrinolytic activity of blood [71,72].…”

Section: Partmentioning

confidence: 99%

The Dynamics of the Hemostatic Parameters in Physiological Pregnancy and After Delivery

Моmot¹

2016

HBTD

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Nowadays hematologists and obstetrician-gynecologists have little data about the peculiarities of hemostatic parameters and the maintenance of hemostatic balance at different stages of physiological pregnancy. However, it is necessary to know the norms for the determination of pathologic deviations in the system and medical decision making. The article presents the dynamics of 50 hemostatic parameters in women in pregravid period, at different stages of physiological pregnancy, and 2-3 days after vaginal delivery studied in 301 Caucasian (white) women. The parameters that characterize different components of hemostatic system were taken into account-vascular-platelet, coagulant, anticoagulant, and Fibrinolytic. Thrombin generation test was used as an integrated method to study hemocoagulation.According to the obtained results, some parameters were identified. These parameters could be an objective prerequisite for the prescription and monitoring the effects of antiaggregants and low molecular heparins during pregnancy with the aim of thromboprophylaxis. It is suggested that hyperproduction of Tissue Factor (TF) and thrombin (in relation to reference ranges) should play a possible role in initiation not only intravascular blood coagulation but also the end of pregnancy. It might be of importance in understanding the causes of preterm delivery. The described mechanism, preventing thrombus formation in late pregnancy, is associated with the enhancement of fibrinolytic reactions in blood circulation. This mechanism can lead to the degradation of soluble fibrin polymer (with the formation of D-dimers) before its conversion into gel or fibrin clot (fibrin insolubile). The obtained data could be useful in future to identify pregnant women at risk dealing with thrombosis, bleeding and obstetrics complications during pregnancy and delivery.Keywords: Blood coagulation markers; Coagulation factors; Fibrinolysis; Hemostatic system; Physiological anticoagulants; Pregnancy; Thrombin generation Citation: Моmot AP, Semenova NA, Belozerov DE, Trukhina DA, Kudinova IY (2016) interest since these data can be useful for the differential diagnostics of bleeding causes, as well as for the identification of patients needed in thromboprophylaxis.Moreover, simultaneous identification of a lot of parameters, characterizing coagulation, anticoagulant and fibrinolytic activity of blood could allow obtaining the important information about dynamically changing hemostatic balance during pregnancy, which is normally accompanied by neither bleedings nor thromboses. The study of these parameters is expected to explain the causes of 3-4 fold increase in D-dimers level in late physiological pregnancy, to select objective factors for initiation and cessation of heparinprophylaxis and to solve other problems associated with pregnancy complications.The aim of this study is to determine the allowed values and the dynamics of changes of a wide range of hemostatic parameters at different stages of physiological pregnancy and the first few day...

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“…Plasminogen levels, tissue plasminogen activator (t-PA), and urokinase-type plasminogen activator (u-PA) antigen increase throughout the pregnancy, 9,52,72,[74][75][76][77][78] whereas t-PA activity decreases remarkably. 74,78 There occurs a rise in levels of both plasminogen inhibitors (PAI-1, which increases up to four times the nonpregnant values, 52,60,[75][76][77]79 and PAI-2, which is placenta-derived, increases five times until delivery, compared with the I trimester values). 60,75,77,79 The fast plasmin inhibitor α 2 -antiplasmin is unchanged during pregnancy.…”

Section: Hemostatic Changes During Normal Pregnancy Molecular Changesmentioning

confidence: 99%

Classic and Global Hemostasis Testing in Pregnancy and during Pregnancy Complications

Ataullakhanov

Koltsova

Баландина³

et al. 2016

Semin Thromb Hemost

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Pregnancy is associated with a significant procoagulant shift in the hemostatic system balance as well as other metabolic changes. Pregnancy can thereby provoke manifestation of otherwise dormant disorders of hemostasis (e.g., thrombophilia), or even cause new, pregnancy-specific disorders (e.g., HELLP syndrome). Application and interpretation of laboratory assays of hemostasis in pregnancy is particularly challenging, because normal physiological ranges are no longer applicable, and because the most dangerous and complex changes are not detected by classic routine coagulation/platelet assays. New global assays of coagulation and of platelet-dependent hemostasis appear to be promising in this respect, but are still far from clinical practice and rarely appear in current patient management guidelines. These global assays require a high level of research to identify their relationship to clinically significant outcomes. Here, we review the state-of-the-art knowledge of the molecular changes in the hemostatic system in normal pregnancy and during pregnancy-related complications (preeclampsia, thrombotic microangiopathies, antiphospholipid syndrome, etc.). We also discuss the sensitivity of various classic and innovative assays to these pregnancy-associated changes, and describe current and potential future applications of these assays in meeting specific clinical needs.

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t-PA activity in peripheral blood obtained from pregnant women

Cited by 26 publications

References 5 publications

APC Resistance and other Haemostatic Variables during Pregnancy and Puerperium

APC Resistance and other Haemostatic Variables during Pregnancy and Puerperium

The Dynamics of the Hemostatic Parameters in Physiological Pregnancy and After Delivery

Classic and Global Hemostasis Testing in Pregnancy and during Pregnancy Complications

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