T-Lymphocyte Subsets Alteration, Infection and Renal Outcome in Advanced Chronic Kidney Disease

Xiong, Jiachuan; Qiao, Yu; Yu, Zhikai; Huang, Yinghui; Yang, Kang; He, Ting; Zhao, Jinghong

doi:10.3389/fmed.2021.742419

Cited by 13 publications

(13 citation statements)

References 46 publications

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“…So, the increase of Th17 cells in NMO patients did not mean the increase of the total CD4 + T cells and CD4/CD8. Xiong et al [32] found that CD4 + T cells and CD4/CD8 were significantly decreased in chronic kidney disease, and Wang et al [33] found decreased CD4 + T cells and CD4/CD8 ratio in systemic lupus erythematosus, which support our ideas. However, we still need a deeper understanding of T-cell immunophenotyping.…”

Section: Discussionsupporting

confidence: 88%

Lymphocyte Subsets Are Associated with Disease Status in Neuromyelitis Optica Spectrum Disorders

Hong¹,

Liu

et al. 2021

Neuroimmunomodulation

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Objective: At present, studies on lymphocytes are mostly conducted on CD19+ B cells and CD27+ B cells in neuromyelitis optica spectrum disorders (NMOSDs), but the exact changes in lymphocyte subsets (CD19+ B cells, CD3+ T cells, CD4+ Th cells, CD8+ Ts cells, the CD4+/CD8+ ratio, and NK [CD56+ CD16] cells) have rarely been studied. This study aimed to assess lymphocyte subset changes in patients with NMOSD. Methods: We performed a cross-sectional study of consecutive patients with acute NMOSD (n = 41), chronic NMOSD (n = 21), and healthy individuals (n = 44). Peripheral blood samples were obtained upon admission, and lymphocyte subsets were analyzed by flow cytometry. Levels of lymphocyte subsets among 3 groups were compared and its correlation with the length of spinal cord lesions was analyzed. Results: The levels of peripheral blood CD19+ B cells were significantly higher in patients with acute and chronic NMOSD than in healthy controls (HCs) (17.91 ± 8.7%, 13.08 ± 7.562%, and 12.48 ± 3.575%, respectively; p < 0.001) and were positively correlated with the length of spinal cord lesions in acute NMOSD (r = 0.433, p < 0.05). The peripheral blood CD4+/CD8+ ratio was significantly lower in patients with acute NMOSD and chronic NMOSD than in HCs (1.497 ± 0.6387, 1.33 ± 0.5574, and 1.753 ± 0.659, respectively; p < 0.05), and the levels of peripheral blood NK (CD56+ CD16) cells were significantly lower in patients with acute and chronic NMOSD than in HCs (13.6 ± 10.13, 11.11 ± 7.057, and 14.7 [interquartile range = 9.28], respectively; p < 0.01). Conclusions: The levels of certain subsets of peripheral blood lymphocytes are associated with disease status in NMOSD.

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Section: Discussionsupporting

confidence: 88%

Lymphocyte Subsets Are Associated with Disease Status in Neuromyelitis Optica Spectrum Disorders

Hong¹,

Liu

et al. 2021

Neuroimmunomodulation

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“…It has been shown that a significant reduction in T-cell subsets, particularly CD4 + and CD8 + subsets, in the CKD population is a critical factor in the exacerbation of CKD. [65,66] In the present study, JUND was shown to be significantly and positively correlated with T cell CD8 + subpopulations, suggesting that JUND may promote the expression of T cell CD8 + subpopulations to reduce the progression of CKD. In the current investigation, a significant positive correlation was observed between AFF1, ZFP36L1, and M2 macrophages, indicating that AFF1 and ZFP36L1 potentially contribute to the upregulation of M2 macrophage expression in CKD.…”

Section: Discussionsupporting

confidence: 57%

Exploration of the shared genetic biomarkers in Alzheimer’s disease and chronic kidney disease using integrated bioinformatics analysis

Li,

Niu

et al. 2023

Medicine

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In order to investigate the potential link between Alzheimer’s disease (AD) and chronic kidney disease (CKD), we conducted a comprehensive analysis using a bioinformatics approach. We downloaded AD and CKD datasets from the Gene Expression Omnibus database and analyzed differentially expressed genes and weighted gene co-expression networks to identify candidate genes for AD and CKD. We used a combination of the least absolute shrinkage and selection operator and random forest algorithms to select the shared genes. Subsequently, we shared genes and performed an immune infiltration analysis to investigate the association between different immune cell types and shared genes. Finally, we elucidated the relationship between the expression levels of the shared genes in disease samples and cells using single-cell analysis. Our analysis identified 150 candidate genes that may be primarily involved in immune inflammatory responses and energy metabolism pathways. We found that JunD Proto-Oncogene, ALF transcription elongation factor 1, and ZFP36 Ring Finger Protein Like 1 were the best co-diagnostic markers for AD and CKD based on the results of Least Absolute Shrinkage Selection Operator analysis and the random forest algorithm. Based on the results of immune infiltration analysis, macrophages and T-cells play a significant role in the progression of AD and CKD. Our scRNA-sequencing data showed that the 3 shared genes in AD were significantly expressed in astrocytes, excitatory neurons, oligodendrocytes, and MAIT cells. The 3 shared genes in CKD were significantly expressed in oligodendrocytes, neutrophils, fibroblasts, astrocytes, and T-cells. JunD Proto-Oncogene, ALF transcription elongation factor 1, and ZFP36 Ring Finger Protein Like 1 genes are the best diagnostic markers for AD and CKD.

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“…External application of traditional Chinese medicine for promoting blood circulation and removing stasis in arteriovenous fistula can not only improve subcutaneous hematoma and promote the dissipation and absorption of hematoma but also prevent the occurrence of stenosis and occlusion of arteriovenous fistula. Studies have suggested that T lymphocyte subsets may change significantly in patients with end-stage renal disease, with significantly reduced levels of CD3+, CD4+, and CD8+T lymphocytes [ 16 ]. The results of this study suggest that the levels of CD3+, CD4+, and CD8+T lymphocytes also play an important role in the occurrence and development of arteriovenous fistula stenosis.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Arteriovenous Fistula Stenosis of Patients with Maintenance Hemodialysis

Gao

Wang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the risk factors of arteriovenous fistula stenosis in maintenance hemodialysis patients. Methods. A total of 80 patients with maintenance hemodialysis in our hospital from January 2017 to January 2022 were included. According to the stenosis degree of the arteriovenous fistula, patients were divided into a stenosis group (n = 35) and an unobstructed group (n = 45). Laboratory examination data, such as the demographic characteristics of patients, past medical history, the use of traditional Chinese medicine (TCM), the TCM for improving blood circulation to promote blood circulation and remove blood stasis, and cellular immune function, were collected. Multivariate Logistic regression analysis was used to analyze the influencing factors. Results. There was no significant difference in the age, sexuality, body mass index, proportion of patients with coronary heart disease, cephalic vein diameter, radial artery diameter, albumin, fibrinogen, and blood calcium levels between the two groups ( P > 0.05 ). Compared with the unobstructed group, the stenosis group had higher rates of diabetes and hypertension as well as significantly higher levels of platelets, parathyroid hormone, and D-dimer ( P < 0.05 ). The proportion of TCM application in the stenosis group was 28.6% (10/35), which was significantly lower than that in the unobstructed group 57.8% (26/45). The difference was statistically significant (χ2 = 6.785, P = 0.009 ). The levels of CD3+ (37.5 ± 5.1% vs. 42.0 ± 4.8%), CD4+ (35.7 ± 3.2% vs. 39.6 ± 3.1%) and CD4+/CD8+ (1.4 ± 0.3 vs. 2.4 ± 1.0) in the stenosis group were significantly lower, while CD8+ level was significantly higher (26.8 ± 5.1% vs. 18.5 ± 6.2%) than that in the unobstructed group ( P < 0.001 ). Logistic regression analysis indicated that the usage of TCM was an independent risk factor for arteriovenous fistula stenosis after adjustment for other factors (odds ratio [OR] 0.302; 95% confidence interval [95% CI] 0.100–0.896; P = 0.039 ). Conclusions. Less use of traditional Chinese medicine for activating blood circulation and removing blood stasis and poor cellular immune function are important factors affecting the function of the arteriovenous fistula in patients with maintenance hemodialysis, which is worthy of clinical attention.

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T-Lymphocyte Subsets Alteration, Infection and Renal Outcome in Advanced Chronic Kidney Disease

Cited by 13 publications

References 46 publications

Lymphocyte Subsets Are Associated with Disease Status in Neuromyelitis Optica Spectrum Disorders

Lymphocyte Subsets Are Associated with Disease Status in Neuromyelitis Optica Spectrum Disorders

Exploration of the shared genetic biomarkers in Alzheimer’s disease and chronic kidney disease using integrated bioinformatics analysis

Risk Factors of Arteriovenous Fistula Stenosis of Patients with Maintenance Hemodialysis

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