T-lymphocyte subset changes in recurrent aphthous stomatitis

Savage, N. W.; Seymour, G. J.; Kruger, B. J.

doi:10.1016/0030-4220(85)90287-7

Cited by 83 publications

(77 citation statements)

References 13 publications

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“…Some authors believe that RAS represents a local defect in immunomodulation with abnormalities in lymphocyte population (both blood stream and aphtous ulcer lymphocytes) resulting in a T CD8 + cell "attack" and subsequent destruction of the epithelium [10][11][12] .…”

Section: Discussionmentioning

confidence: 99%

Aids e estomatite aftóide recidivante

Miziara

Filho

Weber³

2005

Rev. Bras. Otorrinolaringol.

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The immunodeficiency state in HIV infected patients has been the cause of severe episodes of Recurrent Aphthous Stomatitis (RAS). Aim: Our study aims to establish correlation between the manifestations of RAS and the immunosuppression state caused by HIV infection, through counting of CD4+ cells, CD8+ cells, CD4+:CD8+ cells ratio and viral load. Study design: series study. Material and Method: Ninety-four HIV infected patients (25 women and 69 men) with RAS were evaluated in the ENT Department of the University of Sao Paulo-Medical School from January 1998 to December 2003. The age ranged between 19 and 63 years (mean = 35.3 years). The patients were divided in two groups: AIDS group and HIV infected group. Results: The patients with AIDS and HIV infection presented, respectively, eight ulcers and two ulcers by outbreaks. Similarly, patients with major RAS presented smaller counting of cells CD8+, CD4+ and CD4+/CD8+ cells, and higher mean value of viral load than the patients with herpetiform and minor RAS. Between patients with minor and herpetiform RAS there were no statistical differences. Conclusions: The emergence of the lesions, mainly in major RAS, is directly related to the immunological state of the HIV infected patient. These patients frequently present nutritional deficits and worsening in life style. Thus, diagnosis and treatment of RAS is a challenge that should not be neglected.

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Section: Discussionmentioning

confidence: 99%

Aids e estomatite aftóide recidivante

Miziara

Filho

Weber³

2005

Rev. Bras. Otorrinolaringol.

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“…It has been shown that in patients with aphthous stomatitis there is a heightened lymphocytotoxic effect directed against oral epithelial cells when compared to unaffected controls. [24][25][26] Evidence for this pathogenetic mechanism is also inferred from observations that tissue biopsies of newly erupted aphthous ulcerations demonstrate agglomeration of activated T lymphocytes at the periphery of the lesions, whereas in well-established aphthae the initially predominant CD4…”

Section: Immunologic Factorsmentioning

confidence: 99%

“…19,20 It has been proposed that in RAS some unspecified antigenic influence 21 is at the epicenter of an antibody-dependent, T cell-mediated immune response that involves a shift in local lymphocytic subpopulations that eventuates in tissue damage. [22][23][24] From the observations of several investigators it has been hypothesized that the entire process of aphthous ulceration, from initiation through progression, is instigated by the expression on oral epithelial cells of not only normally found HLA class I antigens but also HLA class II antigens. 25 Presumably, this renders the cells antigenically 'foreign' and consequently they become the targets of a cell-mediated immune reaction perpetrated by lymphocytes and Langerhans cells.…”

Section: Immunologic Factorsmentioning

confidence: 99%

“…23,24 Additional indirect support for primary immune dysregulation is reflected in the long-recognized correlation between stress and outbreaks of aphthous ulcers that is reported by many RAS patients, in contrast to the notable decrease in frequency of episodes during periods of reduced stress. 27 This observed association is not entirely surprising, because stress is known to affect immunologic function.…”

Section: Immunologic Factorsmentioning

confidence: 99%

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Etiological Factors of Recurrent Aphthous Stomatitis: A Common Perplexity

Swain¹,

Poonja²,

Penkar³

2012

Journal of Contemporary Dentistry

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“…It is known that for aphthous stomatitis there are 41 genes expressed differently and increased activity of lymphocytes T-helper 1 (Th1), responsible for the production of interferon-gamma, interleukin 2 (IL-2) and alpha tumor necrosis factor (TNF-α). The levels of IL-2 are higher in patients with aphthous stomatitis compared with control subjects and may serve as markers in immunodiagnoses [43,44,45,46,47].…”

Section: Psychological and Genetic Disordersmentioning

confidence: 99%