T Lymphocyte Numbers and Function in Human IgE‐Mediated Allergy

Strannegård, Ö.; Strannegård, Inga-Lisa

doi:10.1111/j.1600-065x.1978.tb01463.x

Cited by 113 publications

(52 citation statements)

References 99 publications

(58 reference statements)

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“…A possible aetiological pathway can be suggested which would link testis cancer to atopy, meningitis, tuberculosis and pneumonia. Patients with atopy probably have deficiencies in T-cell immunity (Buckley & Becker, 1978;Strannegard & Strannegard, 1978). T-cells are also important in defence against tuberculosis (Chaparas, 1982) and T-cell deficiency may be associated with an increased susceptibility to tuberculosis -in several conditions which include suppressed cell mediated immunity there is an excess of tuberculosis (Chaparas, 1982).…”

Section: Opel Ation1smentioning

confidence: 99%

Testicular cancer and antecedent diseases

Swerdlow¹,

Huttly²,

Smith³

1987

Br J Cancer

106

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Summary A case-control study of the aetiology of testicular cancer was conducted using information obtained by interview and from case-notes of 259 cases with testicular cancer and two sets of control patients -238 men with diagnoses other than testicular cancer attending the same radiotherapy centres as those attended by the cases, and 251 hospital in-patients not attending radiotherapy departments. Logistic regrcssion analyses were performed, after stratifying by age and region of residence, to estimate the relative risks (RRs) associated with various aspects of prior medical history. The risk of testicular cancer was found to be raised for men with a history of cryptorchidism (RR based on comparison with all controls =6.3; P<0.001), inguinal hernia (RR= 1.6; P=0.14), mumps orchitis (RR= 12.7; P=0.006), atopy (RR= 1.8; P=0.03), and meningitis (RR=3.0; P=0.21). Inguinal herniorrhaphy before the age of 15 years was particularly a risk factor for seminoma, whereas the relative risks were similar for seminoma and teratoma for the other factors. The results add to the growing evidence that congenital abnormalities involving the process of testicular descent and closure of the processus vaginalis are risk factors for testicular cancer, and that some types of testicular damage later in life may also be important. The findings of associations with previous atopy and certain infections suggest a possible second aetiological mechanism -that immunological abnormalities may be associated with an increased risk of testis cancer.Testicular cancer is one of the commonest cancers in young men and is increasing in incidence in adults in many white populations, but its aetiology remains largely unknown. There is growing evidence of an aetiological role for prenatal factors (Henderson et al., 1979;Loughlin et al., 1980;Schottenfeld et al., 1980;Depue et al., 1983), and testis cancer is associated with some congenital malformations involving abnormalities of genito-urinary tract development. Associations have been shown with cryptorchidism, which is found in about 10% of eases (Morrison, 1976;Henderson et al., 1979;Schottenfeld et al., 1980;Depue et al., 1983;Mills et al., 1984;Pottern et al., 1985), inguinal hernia (Li & Fraumeni, 1972;Morrison, 1976;Swerdlow et al., 1982;Depue et al., 1983) and, for childhood testicular cancer, congenital genito-urinary abnormalities other than cryptorchidism (Li and Fraumeni, 1972;Sakashita et al., 1980;Swerdlow et al., 1982). Adult, but not childhood, testicular cancer incidence has increased in white populations in recent years which suggests that postnatal factors may also be important in the aetiology of the adult disease. Mumps orchitis appears to be an uncommon postnatal cause of the tumour (Beard et al., 1977a; Lin and Kessler, 1979), but there has been little investigation of postnatal disease associations.The present study examined associations between various previous diseases and testicular cancer in data collected in a case-control study conducted in the environs of Oxford and the ...

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Section: Opel Ation1smentioning

confidence: 99%

Testicular cancer and antecedent diseases

Swerdlow¹,

Huttly²,

Smith³

1987

Br J Cancer

106

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“…The observation that serum IgE levels are often elevated in the presence of normal or low IgG levels in many human T cell deficiencies (25,26), including selective deficiency of suppressor T cells (27), further supports this view. Furthermore, some but not all authors (11,12,28) have found a depression of the number of circulating total T cells in patients with atopic diseases, and have suggested that this is a reflection of a suppressor T cell deficiency especially because normal T cells could suppress IgE synthesis by the PBL of atopic patients (16,21,29). Also, Canonica et al (30) An increase in activated suppressor cells is commonly found in infectious diseases of both viral and bacterial origin (32,33).…”

Section: Abstract the Status Of Suppressor T Cells (Ts)mentioning

confidence: 99%

“…INTRODUCTION The hyper IgE syndrome is associated with recurrent infections, chronic pruritic dermatitis, and elevation of serum IgE antibodies, some of which are directed to antigens on Staphylococcus aureus (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). The etiology of this elevation is unclear, although many atopic conditions, including dermatitis and allergic rhinitis associated with increased serum IgE, have been associated with a decrease in the number of circulating total T cell number (11,12). In this regard, however, there is considerable evidence in the murine system to indicate that IgE secretion is closely regulated by suppressor T cells (13).…”

Section: Abstract the Status Of Suppressor T Cells (Ts)mentioning

confidence: 99%

Deficiency of Suppressor T Cells in the Hyperimmunoglobulin E Syndrome

Geha¹,

Reinherz²,

Leung³

et al. 1981

J. Clin. Invest.

134

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“…Many studies suggest a slight defect in cell–mediated immunity in atopic children. Children with atopic dermatitis have lower numbers of lymphocytes forming rosettes with sheep erythrocytes [32]. Using flow cytometry, we could recently confirm that the proportion of lymphocytes expressing CD2, the receptor for sheep erythrocytes, was lower in children with atopic eczema than in nonallergic children [Jenmalm et al, in manuscript].…”

Section: Postnatal Maturation Of T–cell Function In Relation To Atopmentioning

confidence: 66%

T–Cell Function in Atopic Children

Jenmalm¹

1999

Int Arch Allergy Immunol

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T Lymphocyte Numbers and Function in Human IgE‐Mediated Allergy

Cited by 113 publications

References 99 publications

Testicular cancer and antecedent diseases

Testicular cancer and antecedent diseases

Deficiency of Suppressor T Cells in the Hyperimmunoglobulin E Syndrome

T–Cell Function in Atopic Children

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