2018
DOI: 10.1016/j.jpedp.2017.10.007
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T‐lymphocyte‐expressing inflammatory cytokines underlie persistence of proteinuria in children with idiopathic nephrotic syndrome

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(2 citation statements)
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“…Compared with healthy children, the proportion of CD4 + T cells expressing the inflammatory cytokine TNF-α is increased in children with INS, and the proportion of CD8 + T cells expressing IFN-γ is lower [12]. However, glucocorticoids and cyclosporine do not completely inhibit the expression of T-lymphocyte inflammatory cytokines, which may contribute to persistent or frequent recurrence of symptoms and ultimately to inadequate sensitivity to steroids [12]. Furthermore, the results of the study revealed an unbalanced distribution of CD4/CD8 T lymphocytes, which was conducive to recurrences and remissions of CD8 T lymphocytes [13].…”
Section: Discussionmentioning
confidence: 91%
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“…Compared with healthy children, the proportion of CD4 + T cells expressing the inflammatory cytokine TNF-α is increased in children with INS, and the proportion of CD8 + T cells expressing IFN-γ is lower [12]. However, glucocorticoids and cyclosporine do not completely inhibit the expression of T-lymphocyte inflammatory cytokines, which may contribute to persistent or frequent recurrence of symptoms and ultimately to inadequate sensitivity to steroids [12]. Furthermore, the results of the study revealed an unbalanced distribution of CD4/CD8 T lymphocytes, which was conducive to recurrences and remissions of CD8 T lymphocytes [13].…”
Section: Discussionmentioning
confidence: 91%
“…INS diseases may also develop due to an imbalance between CD4 and CD8, which affects immune function [10,11]. Compared with healthy children, the proportion of CD4 + T cells expressing the inflammatory cytokine TNF-α is increased in children with INS, and the proportion of CD8 + T cells expressing IFN-γ is lower [12]. However, glucocorticoids and cyclosporine do not completely inhibit the expression of T-lymphocyte inflammatory cytokines, which may contribute to persistent or frequent recurrence of symptoms and ultimately to inadequate sensitivity to steroids [12].…”
Section: Discussionmentioning
confidence: 99%