T‐lymphocyte‐expressing inflammatory cytokines underlie persistence of proteinuria in children with idiopathic nephrotic syndrome

Guimarães, Fábio Tadeu Lourenço; Melo, Gustavo Eustáquio Brito Alvim de; Cordeiro, Thiago Macedo e; Feracin, Victor; Vieira, Etel Rocha; Pereira, Wagner de Fátima; Pinheiro, Sérgio Veloso Brant; Miranda, Aline Silva de; Simões‐e‐Silva, Ana Cristina

doi:10.1016/j.jpedp.2017.10.007

Cited by 1 publication

(2 citation statements)

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“…Compared with healthy children, the proportion of CD4 + T cells expressing the inflammatory cytokine TNF-α is increased in children with INS, and the proportion of CD8 + T cells expressing IFN-γ is lower [12]. However, glucocorticoids and cyclosporine do not completely inhibit the expression of T-lymphocyte inflammatory cytokines, which may contribute to persistent or frequent recurrence of symptoms and ultimately to inadequate sensitivity to steroids [12]. Furthermore, the results of the study revealed an unbalanced distribution of CD4/CD8 T lymphocytes, which was conducive to recurrences and remissions of CD8 T lymphocytes [13].…”

Section: Discussionmentioning

confidence: 91%

“…INS diseases may also develop due to an imbalance between CD4 and CD8, which affects immune function [10,11]. Compared with healthy children, the proportion of CD4 + T cells expressing the inflammatory cytokine TNF-α is increased in children with INS, and the proportion of CD8 + T cells expressing IFN-γ is lower [12]. However, glucocorticoids and cyclosporine do not completely inhibit the expression of T-lymphocyte inflammatory cytokines, which may contribute to persistent or frequent recurrence of symptoms and ultimately to inadequate sensitivity to steroids [12].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral blood lymphocyte subsets in children with nephrotic syndrome: a retrospective analysis

Deng

et al. 2023

BMC Nephrol

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Background Nephrotic syndrome (NS) in children is widely believed to be associated with severe changes in the immune system. Based on lymphocyte subset analysis, we examined the pathogenesis of immune deficiencies in children with NS with varying steroid sensitivity. Methods Our study utilized flow cytometry to retrospectively analyze the ratios of lymphocyte subsets in 204 children with nephrotic syndrome and 19 healthy children. Results Compared with healthy children, the ratio of CD4 + /CD8 + in onset and remission was decreased in SRNS group (p < 0.05), and CD19 + B lymphocytes were increased in onset (p < 0.05). Compared with onset, the proportion of CD19 + B lymphocytes decreased in SRNS, while the proportion of CD19 + B lymphocytes increased in SDNS, p < (0.01). The ratio of CD8 + T/CD19 + B in onset in SDNS group was significantly higher than that in SSNS and SRNS groups (p < 0.01) and healthy control group (p < 0.05). Compared with onset, the ratio of CD8 + T/CD19 + B in SDNS group decreased significantly (p < 0.01), while the ratio of CD8 + T/CD19 + B in SRNS group increased significantly (p < 0.01). The proportion of CD56 + CD16 + NK cells was significantly reduced in children with INS (p < 0.01). Conclusion CD8 + T lymphocytes may be involved in the mechanism of lymphocyte subsets disorder during onset of SDNS, while CD19 + B lymphocytes may be involved in the mechanism of lymphocyte subsets disorder during relapse of SDNS. The CD8 + T/CD19 + B ratio may predict the degree of frequent recurrence. There is a certain degree of lymphoid subsets disorder in children with NS.

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Section: Discussionmentioning

confidence: 91%