T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2

Dang, Guohui; Li, Tianrun; Yang, Dongmin; Yang, Guangxin; Du, Xing; Yang, Juan; Miao, Yütong; Han, Lulu; Ma, Xiaolong; Song, Yuwei; Liu, Bo; Li, Xuan; Wang, Xian; Feng, Juan

doi:10.1016/j.redox.2022.102257

Cited by 19 publications

(21 citation statements)

References 58 publications

(70 reference statements)

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“…The activated lymphocyte-derived EVs then promote macrophage migration, lipid peroxidation, and iron accumulation, which drive aortic aneurysm progression. Corollary findings are noted in patients with AAAs, highlighting the translational value of these findings [ 92 ]. Thus, inflammation plays a prominent role in aortic aneurysm development, especially AAAs.…”

Section: The Role Of Evs and Inflammation In Specific Cardiovascular ...mentioning

confidence: 93%

“…Finally, the interaction between adaptive and innate immunities must be considered in aneurysm development. Activated T lymphocytes within vascular lesions are noted to have increased pyruvate kinase muscle isozyme 2 (PKM2) expression [ 92 ]. Importantly, these lymphocytes release EVs that are rich in polyunsaturated-fatty-acid-containing phospholipids and are taken up by macrophages.…”

Section: The Role Of Evs and Inflammation In Specific Cardiovascular ...mentioning

confidence: 99%

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Extracellular Vesicles, Inflammation, and Cardiovascular Disease

Akhmerov

Parimon

2022

Cells

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Cardiovascular disease is a leading cause of death worldwide. The underlying mechanisms of most cardiovascular disorders involve innate and adaptive immune responses, and extracellular vesicles are implicated in both. In this review, we describe the mechanistic role of extracellular vesicles at the intersection of inflammatory processes and cardiovascular disease. Our discussion focuses on atherosclerosis, myocardial ischemia and ischemic heart disease, heart failure, aortic aneurysms, and valvular pathology.

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Section: The Role Of Evs and Inflammation In Specific Cardiovascular ...mentioning

confidence: 93%

Section: The Role Of Evs and Inflammation In Specific Cardiovascular ...mentioning

confidence: 99%

Extracellular Vesicles, Inflammation, and Cardiovascular Disease

Akhmerov

Parimon

2022

Cells

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“…Oxidative stress, attributable to increased free radical formation and/or decreased free radical scavenging, triggers endothelial dysfunction, immune cell 10.3389/fncel.2022.1016682 infiltration, and VSMC proliferation and migration (Griendling and FitzGerald, 2003;Canes et al, 2021). After pyuvate kinase muscle isozyme 2 activation and lipid peroxidation, T lymphocyte-derived extracellular vesicles exacerbate abdominal aortic aneurysms (Dang et al, 2022). Numerous studies have found that smoking is an independent risk factor for IA, and cigarette extract specifically-triggered ferroptosis of VSMC raises the possibility that ferroptosis may contribute to the pathogenesis of aneurysms (Meschia et al, 2014;Bakker et al, 2020;Sampilvanjil et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis constructs potential ferroptosis-related ceRNA network involved in the formation of intracranial aneurysm

Zhu

Tan

Wang

et al. 2022

Front. Cell. Neurosci.

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BackgroundIntracranial aneurysm (IA) causes more than 80% of nontraumatic subarachnoid hemorrhages (SAHs). The mechanism of ferroptosis involved in IA formation remains unclear. The roles played by competitive endogenous RNA (ceRNA) regulation networks in many diseases are becoming clearer. The goal of this study was to understand more fully the ferroptosis-related ceRNA regulation network in IA.Materials and methodsTo identify differentially expressed genes (DEGs), differentially expressed miRNAs (DEMs), and differentially expressed lncRNAs (DELs) across IA and control samples, the GEO datasets GSE122897 and GSE66239 were downloaded and analyzed with the aid of R. Ferroptosis DEGs were discovered by exploring the DEGs of ferroptosis-related genes of the ferroptosis database. Potentially interacting miRNAs and lncRNAs were predicted using miRWalk and StarBase. Enrichment analysis was also performed. We utilized the STRING database and Cytoscape software to identify protein-protein interactions and networks. DAB-enhanced Prussian blue staining was used to detect iron in IA tissues.ResultsIron deposition was evident in IA tissue. In all, 30 ferroptosis DEGs, 5 key DEMs, and 17 key DELs were screened out for constructing a triple regulatory network. According to expression regulation of DELs, DEMs, and DEGs, a hub triple regulatory network was built. As the functions of lncRNAs are determined by their cellular location, PVT1-hsa-miR-4644-SLC39A14 ceRNA and DUXAP8-hsa-miR-378e/378f-SLC2A3 ceRNA networks were constructed.ConclusionCeRNA (PVT1-hsa-miR-4644-SLC39A14 and DUXAP8-hsa-miR-378e/378f-SLC2A3) overexpression networks associated with ferroptosis in IA were established.

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“…This result has revealed how T cells interact with macrophages and suggested a potential targeted therapeutic strategy for AAA. 106 In addition, anti-inflammatory molecules (LysoPS, 7-α, 25-dihydroxycholesterol and 15-d-PGJ2) and coagulation (thromboxane and ellagic acid) related metabolites in EVs may play critical roles in reducing inflammation of COVID-19. 74 EVs metabolomic analysis was also applied to monitor glioblastoma.…”

Section: What Is the Potential Of Metabolomics Of Extracellular Vesic...mentioning

confidence: 99%

Metabolomics of Extracellular Vesicles: A Future Promise of Multiple Clinical Applications

Wu¹,

Chen²,

Guo³

et al. 2022

IJN

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Extracellular vesicles (EVs) can contain DNA, RNA, proteins and metabolic molecules from primary origins; they are coated with a phospholipid bilayer membrane and released by cells into the extracellular matrix. EVs can be obtained from various body liquids, including the blood, saliva, cerebrospinal fluid, and urine. As has been proved, EVs-mediated transfer of biologically active molecules is crucial for various physiological and pathological processes. Extensive investigations have already begun to explore the diagnosis and prognosis potentials for EVs. Furthermore, research has continued to recognize the critical role of nucleic acids and proteins in EVs. However, our understanding of the comprehensive effects of metabolites in these nanoparticles is currently limited and in its infancy. Therefore, we have attempted to summarize the recent research into the metabolomics of EVs in relation to potential clinical applications and discuss the problems and challenges that have occurred, to provide more guidance for the future development in this field.

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T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2

Cited by 19 publications

References 58 publications

Extracellular Vesicles, Inflammation, and Cardiovascular Disease

Extracellular Vesicles, Inflammation, and Cardiovascular Disease

Bioinformatics analysis constructs potential ferroptosis-related ceRNA network involved in the formation of intracranial aneurysm

Metabolomics of Extracellular Vesicles: A Future Promise of Multiple Clinical Applications

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