T Lymphocyte Cytokine Profile at a Single Cell Level in Alveolar Echinococcosis

Increased Activation and Oligoclonality of Peripheral CD8+T Cells in the Chronic Human Helminth Infection Alveolar Echinococcosis

“…However, considering that the adult liver is an organ without constitutive lymphoid components, any intrahepatic T cell found in AE should have migrated into the liver after infection and might also reappear in the circulation. Most likely, the activated CD8 ϩ T cells are the in vivo correlate of a dominant response of CD8 ϩ T cells after in vitro stimulation of peripheral lymphocytes with E. multilocularis vesicular fluid antigen, as previously reported by our group (23). Increased activation of peripheral CD8…”

“…Previous work of our group has shown IL-10 production of CD8 ϩ T cells in response to E. multilocularis (23). This finding suggests a regulatory role for these cells.…”

“…However, the liver lesion in most patients with AE harbors an infiltrate composed mainly of activated CD8 ϩ T cells (7). Recently, our group provided evidence for the presence of circulating antigen-specific effector CD8 ϩ T cells in AE patients (23). In an effort to substantiate these data, we now studied the phenotype of peripheral T-cell subsets in patients chronically infected with E. multilocularis and otherwise free of overt diseases in comparison with that in age-matched healthy controls.…”

Current trends in tissue-affecting helminths

“…IL-10-induced inhibition of effector macrophages but also of antigen-presenting dendritic cells may be operating to protect the parasitic growth and survival (Vuitton et al, 2003). Susceptibility to infection in humans associates with predominantly TH2-related immunity (Wellinghausen et al, 1999), including IL-10 (Godot et al, 1997;, IL-4 (Kilwinski et al, 1999), IL-5 (Sturm et al, 1995) production, especially during chronic stage of infection.…”

Immune response of mice to Echinococcus multilocularis infection after therapy with amphotericin B colloidal dispersion

“…The Th2 reversion contributes to longtime manifestation of E. multilocularis infection in humans (Sturm et al, 1995). The E. multilocularis metacestode can specifically manipulate the balance between Th1 and Th2 response leading to reduced effectiveness of the immune response (Kilwinski et al, 1999;Vuitton, 2003). The AMB distribution in vivo and its efficacy can be modified by several factors -the drug's ability to bind to selected molecules from plasma, to bind to tissues and organs, and the ability of vesicles of differing sizes to traverse the endothelium (Brajtburg & Bolard, 1996).…”