T lymphocyte cell: A pivotal player in lung cancer

Wu, Yanan; Yuan, Meng; Wang, Chenlin; Chen, Yanfei; Zhang, Yan; Zhang, Jiandong

doi:10.3389/fimmu.2023.1102778

Cited by 13 publications

(9 citation statements)

References 184 publications

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“…Tc1 cells constitute the most prevalent subset of tumorinfiltrating lymphocytes in multiple types of cancers, including lung cancers 20 , breast cancers 21 , and chronic lymphocytic leukemia 22 , and are associated with favorable prognoses [23][24][25][26][27] . Tumors exhibiting a high degree of infiltration by Tc1 cells that subsequently produced elevated levels of IFN-γ are referred to as "hot" tumors.…”

Section: Cytotoxic Cd8 + T Cells (Tc1 Cells)mentioning

confidence: 99%

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

Koh,

Lee,

Kwak

et al. 2023

Exp Mol Med

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CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant cells. Traditionally, cytotoxic T cells, characterized by their ability to produce effector cytokines and release cytotoxic granules to directly kill target cells, have been recognized as the constituents of the predominant effector T-cell subset. However, emerging evidence suggests distinct subsets of effector CD8 T cells that each exhibit unique effector functions and therapeutic potential. This review highlights recent advancements in our understanding of CD8 T-cell subsets and the contributions of these cells to various disease pathologies. Understanding the diverse roles and functions of effector CD8 T-cell subsets is crucial to discern the complex dynamics of immune responses in different disease settings. Furthermore, the development of immunotherapeutic approaches that specifically target and regulate the function of distinct CD8 T-cell subsets holds great promise for precision medicine.

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Section: Cytotoxic Cd8 + T Cells (Tc1 Cells)mentioning

confidence: 99%

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

Koh,

Lee,

Kwak

et al. 2023

Exp Mol Med

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“…Activated RhoA leads to the formation of stress fibers within cells and expression of chemokines, cytokines, and growth factors [54,55]. The important role of immune function in the incidence and development of lung cancer is well established [56][57][58]. As reported, fermented cordyceps powder reduces radiation-induced bone marrow suppression, increases the percentage of peripheral blood leukocytes, improves chemotherapy tolerance, and promotes spleen cell proliferation, NK cell activity, and T-helper cytokine secretion in mice with impaired immune function [59,60].…”

Section: Discussionmentioning

confidence: 99%

Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway

Lu,

Zhou,

Chu

et al. 2024

Chin Med

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Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway.

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“…The presence of a larger population of Tregs in this microenvironment was found to be linked with a detrimental prognosis [33,34]. It has been demonstrated that T, B lymphocytes, and NK cells (collectively referred to as TBNK) play a role in combating tumors within the lung tumor environment [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Causal role of immune cells in lung cancer: Mendelian randomization study

2023

Preprint

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In this study, we aimed to investigate the relationship between immune cell responses and lung cancer (LC), which is responsible for a significant number of cancer-related deaths globally and poses a serious threat to human well-being. Numerous studies have suggested a potential connection between immune cell activity and LC; nevertheless, the exact causal role of immune cells in LCremains uncertain. To address this gap in knowledge, we conducted a thorough two-sample Mendelian randomization (MR) analysis to establish a causal link between immune cell signatures and LC.By analyzing genetic data that is accessible to the public, we investigated potential cause-and-effect relationships between 731 immune cell signatures and the risk of LC. We considered four different types of immune signatures, including median fluorescence intensities (MFI), relative cell (RC), absolute cell (AC), and morphological parameters (MP). To ensure the reliability and validity of our findings, we conducted thorough sensitivity analyses to assess the robustness, variability, and potential confounding effects of the results.The analysis of Two-sample Mendelian randomization (MR) revealed a significant causal impact of 31 immune cells on LC. Conversely, the results of Reverse MR indicated a significant causal association between LC and 3 immune cells. By employing genetic methods, our study has effectively illustrated the strong connection between immune cells and LC, offering valuable insights for future clinical investigations.

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T lymphocyte cell: A pivotal player in lung cancer

Cited by 13 publications

References 184 publications

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway

Causal role of immune cells in lung cancer: Mendelian randomization study

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