T

Gressner, A. M.; Arndt, T.

doi:10.1007/978-3-540-49520-8_20

Cited by 4 publications

(12 citation statements)

References 77 publications

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“…43 We have observed the change in inflammation markers due to trauma during surgery. 42 , 44 We could observe a slight average increase of urea and creatinine that remained within the standard range. Generally, urea may rise due to fever, trauma, hypovolemia, or a catabolic state of metabolism.…”

Section: Discussionmentioning

confidence: 72%

“… 40 Since all increased CRP values remained below 200 mg/L and declined within a short period of time, there were no signs of postoperative infections. 41 , 42 Leukocytosis is not only a sign of chronic inflammation, but also a sign of metabolic crisis, acute blood loss, acute hemolysis as well as pain or the body’s reaction to stress. 43 We have observed the change in inflammation markers due to trauma during surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Generally, urea may rise due to fever, trauma, hypovolemia, or a catabolic state of metabolism. 42 , 45 Creatinine is primarily a sign of acute renal dysfunction, possibly severe blood loss, damages due to drugs, hemolysis, and chronic renal damage. 42 Both parameters can rise to values above the upper reference range limit shortly after a surgery, due to trauma and blood loss.…”

Section: Discussionmentioning

confidence: 99%

“… 42 , 45 Creatinine is primarily a sign of acute renal dysfunction, possibly severe blood loss, damages due to drugs, hemolysis, and chronic renal damage. 42 Both parameters can rise to values above the upper reference range limit shortly after a surgery, due to trauma and blood loss. Altogether, the analysis of laboratory parameters showed changes matching a physiological response to surgical trauma.…”

Section: Discussionmentioning

confidence: 99%

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Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Moghaddam

Graeser

Westhauser

et al. 2016

TCRM

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IntroductionOsteitis is one of the most serious complications in orthopedic surgery. Expert Tibia Nail (ETN) PROtect™ coated with a biodegradable layer of gentamicin-laden polymer was developed for prophylaxis of osteomyelitis. In systemic administration, gentamicin has only a small therapeutic index and serious side effects; it is potentially nephrotoxic as well as ototoxic. It is not yet known if relevant gentamicin concentrations are released into the systemic circulation after implantation of gentamicin-coated nails. In order to evaluate the patients’ risks profiles and increase patient safety, we measured gentamicin levels in pre- and postoperative serum samples of patients undergoing implantation of ETN PROtect.MethodsTwenty-five patients who received ETN PROtect between March 2012 and August 2014 were included in this study. Collection of blood samples occurred before the operation, at weeks 1–4, 3 and 6 months, and up to 1 year after the implantation. Measurement of gentamicin levels in serum samples was performed at the central laboratory of Heidelberg University Hospital. Additionally, laboratory parameters, C-reactive protein, leukocyte number, urea and creatinine concentrations were analyzed in routine controls before and after operating and assessed for systemic side effects.ResultsOver the course of this prospective observational study, we were able to determine that gentamicin-coated nails do not release gentamicin into the systemic circulation above the lowest detectable level of 0.2 mg/dL. There were slight increases in the mean inflammation and renal retention markers, but no gentamicin-associated side effects could be linked to implantation. Furthermore, no allergic reactions could be detected during our study.ConclusionOur findings suggest that there is no relevant release of gentamicin into the systemic circulation causing a systemic effect, and serious side effects due to gentamicin-coated tibia nails should not be feared. Postoperative monitoring of renal function does not seem necessary because of the implantation of ETN PROtect.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Moghaddam

Graeser

Westhauser

et al. 2016

TCRM

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“…Serum was immediately separated and stored at -30°C until the blood analysis was performed. Commercially available indirect immofluorescence tests (Euroimmun, Lübeck, Germany) were used to detect total antinuclear antibodies (ANA) (26) , on human-epithelial type 2 cells (HEp-2-cells). Titers <1:100 were considered negative.…”

Section: Blood Samplesmentioning

confidence: 99%

Antinuclear antibodies in postinfectious smell loss - a pilot study

Walliczek-Dworschak¹,

Zimmermann²,

Poletti³

et al. 2019

RHINOL

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Background: Numerous diseases are mediated by autoimmune mechanisms some of which have been shown to be associated with reduced olfactory function, e.g. systemic lupus erythematosus, Sjögren syndrome, psoriasis vulgaris. Postinfectious smell loss is a frequent cause of olfactory dysfunction. However, its nature is not fully understood, but connections to immune mediated processes might be possible. The primary aim of the present study was therefore to investigate the possible relation of postinfectious smell loss with autoimmune processes. Methods: Fifty-two patients (35 female, 17 male; mean age 57 years ± 12 years) with postinfectious smell loss and 56 controls (21 female, 35 male; mean age 58 years ± 13 years), with olfactory dysfunction of other causes (sinunasal, posttraumatic or idiopathic)were included in the present study. The patients' olfactory function was measured using the extended test battery of the "Sniffin' Sticks". Furthermore venous blood samples were taken and analyzed for antinuclear autoantibodies. Results:Patients showed anti-nuclear antibodies (ANA) significantly more frequently compared to controls, although ANAs were typically only present at cut off levels of 1:100. In addition, there was a significant association between the presence of ANAs and odor thresholds. Conclusions:Results from this study indicate that postinfectious olfactory dysfunction may be associated with autoimmune processes, as they show significantly more ANAs -although not at a clincially significant level -compared to patients with olfactory deficits of other origin.

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Determining Immunoglobulin Content of Bovine Colostrum and Factors Affecting the Outcome: A Review

Ahmann

Steinhoff‐Wagner

Büscher

2021

Animals

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The immunoglobulin concentration in bovine colostrum should be measured to ensure feeding with sufficient immunoglobulins (≥50 mg immunoglobulin G mL−1). Adequate feeding prevents diseases, promotes development, and has a positive influence on the adult animal. Indirect and direct measurement methods are available for this purpose. Direct measurement methods cannot be easily used in practice; therefore, farmers use indirect methods such as a colostrometer and a refractometer. Many factors influence the immunoglobulin concentration of colostrum; some of them have already been intensively researched. In particular, lactation and temporal aspects play an essential role. Newer aspects such as dry period, seasonal influences, and genetics are gaining importance, but their impact on immunoglobulin content has not been sufficiently investigated. Developments are still needed, especially in data management. This review analyzes the outcome of different studies on the indirect and direct measurement methods and discusses different factors influencing the immunoglobulin concentration of bovine colostrum.

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T

Cited by 4 publications

References 77 publications

Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Antinuclear antibodies in postinfectious smell loss - a pilot study

Determining Immunoglobulin Content of Bovine Colostrum and Factors Affecting the Outcome: A Review

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Cited by 4 publications

References 77 publications

Patients&rsquo; safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Patients&rsquo; safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Antinuclear antibodies in postinfectious smell loss - a pilot study

Determining Immunoglobulin Content of Bovine Colostrum and Factors Affecting the Outcome: A Review

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Product

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Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?