T‐gamma gene rearrangement and CMV mononucleosis

Abstract

A clonal T-gamma rearrangement was found in peripheral blood and bone marrow in a 57-year-old female who presented with 6-week history of fevers, night sweats, and weight loss. Splenomegaly, hemolytic anemia, atypical lymphocytosis, a marrow lymphoid aggregate, and elevated LDH had suggested lymphoproliferative disease. However, IgM serology for cytomegalovirus (CMV) was positive. With observation alone, her clinical features improved over 4 weeks with normalization of the blood count and disappearance of CMV viremia and the aberrant T-gamma clone. Acute CMV infection may mimic lymphoproliferative disease. T-gamma gene rearrangement may be part of the immune response to CMV infection and is not specific to lymphoid neoplasia. Am. J. Hematol. 66:64-66, 2001.

Transient monoclonal expansion of CD8+/CD57+ T‐cell large granular lymphocytes after primary cytomegalovirus infection

“…In all cases, a TCR monoclonality was demonstrated on PBMC. In 4/5 cases, the monoclonal T-cell expansion was transient with a duration that ranged from 2 to 6 months [5,6,8 and this study]. In one case, the monoclonal T-cell expansion persisted until the last follow-up at 21 months [7].…”

“…To date, in the context of immunocompetent hosts, only four cases of CD81 T-cell monoclonal expansion developing during viral infection have been described [5][6][7][8] in addition to the present study.…”

“…In one case, no viral infection could be demonstrated after extensive screening [5]. Splenomegaly occurred in 2/5 cases [6,7]. Transaminasitis occurred in 4/5 cases [5,7,8 and this case].…”

“…Lymphocytosis associated with viral infection is generally polyclonal or oligoclonal [1]. Monoclonal proliferations of T-lymphocytes occurring during viral infection have been reported in the context of immunodeficiency [2][3][4], whereas they are rarely described in immunocompetent host [5][6][7][8].…”

Coimmunisation with type I IFN genes enhances protective immunity against cytomegalovirus and myocarditis in gB DNA-vaccinated mice

“…Cytomegalovirus (CMV) causes latent, persistent and recurring infections in immunocompromised or immunosuppressed individuals with various disease sequelae including pneumonitis, 9 hepatitis, 10 mononucleosis, 11 and myocarditis. 12,13 Active CMV infection has been associated with higher rates of severe allograft rejection and cardiac dysfunction, in heart transplant recipients and patients with AIDS, respectively.…”