T follicular helper cells: Their development and importance in the context of helminthiasis

Oliveira, Yvanna Louise Di Christine; Oliveira, Luciana M.; Cirilo, Tatyane Martins; Fujiwara, Ricardo Toshio; Bueno, Lilian Lacerda; Dolabella, Silvio Santana

doi:10.1016/j.clim.2021.108844

Cited by 2 publications

(1 citation statement)

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“…The former can be further differentiated into two basic phenotypes according to the surface marker of cluster of differentiation (CD): cytotoxic T cells, which can be distinguished by the CD8, and T helper cells (Th), which are characterized by CD4. As one subpopulation of CD4 + T lymphocytes, follicular helper T cells (Tfh) are usually but not exclusively found in the lymph nodes and spleen, while the other Th cells are predominantly found in lymphoid tissues and blood [1,2]. They can provide signals directed to B cells located in the germinal center (GC) to promote differentiation and antibody generation [3].…”

Section: Introductionmentioning

confidence: 99%

Follicular Helper T Cells and Autoimmune Diseases

Liu,

Gao,

Wei

et al. 2024

Biology of T Cells in Health and Disease [Working Title]

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Follicular helper T (Tfh) cells can control the antibody affinity maturation and memory by supporting the formation of germinal center (GC) and regulating clonal selection and differentiation of memory and antibody-secreting B cells. Therefore, Tfh cells play an important role in the development of some autoimmune diseases, such as rheumatoid arthritis and autoimmune hepatitis. The generation and function of Tfh cells are determined by T-cell antigen receptor (TCR), co-stimulation, and cytokine signals, together with specific mechanisms. In this part, the specialization, development, and regulation of metabolic and differentiation mechanisms on Tfh cells will be summarized, which is crucial to understanding pathogenesis and informing the development of emerging therapies for autoimmune diseases.

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Section: Introductionmentioning

confidence: 99%