T.E. Hulme and Modernism

Abstract

T. E. Hulme (1883-1917) was the author of a small number of poems and some genuinely innovative critical and philosophical writings. From this modest output his influence on later writers was considerable: T. S. Eliot described his poems as “beautiful” and Ezra Pound and Wyndham Lewis were both inspired by his work. T.E. Hulme and Modernism explores his impact on key modernist figures, and also shows where this influence has been misplaced or misinterpreted. Oliver Tearle also here suggests that Hulme”s significance goes beyond his influence on modernism, and that his work provides new ways of thinking about creative and critical writing in the twenty-first century. What is poetry? What is the purpose of literary criticism? And how might the strange phenomenon of the fragment offer new ways of theorising such issues? In exploring these and other important matters this book pushes at the boundaries of literary criticism and of writing itself.

A Review of Dendrophthoe pentandra (Mistletoe): Phytomorphology, Extraction Techniques, Phytochemicals, and Biological Activities

“…Compared to the normal cell L929, all extracts showed no remarkable effect with IC 50 values compared to 100 µg/mL and thus did not affect proliferation toward normal cells [15]. Furthermore, D. pentandra ethanolic extracts have been shown to enhance the anticancer effect of doxorubicin in MCF-7 cells [17]. The intracellular calcium and survivin levels were reduced significantly, while the combination of apoptotic cells with doxorubicin (5 µg/mL) and D. pentandra extracts were investigated (25 and 50 µg/mL) [17].…”

“…Plant metabolites such as alkaloids, biomolecules, flavonoids, gums, glycosides, lignans, minerals, saponins, taxanes, terpenes, vitamins, and oils play significant roles in inhibiting cancer progression via multiple mechanisms [77]. Numerous previous studies have been conducted for D. pentandra extracts on combating cancer cells [8,[11][12][13][14][15][16][17][18].…”

“…Furthermore, D. pentandra ethanolic extracts have been shown to enhance the anticancer effect of doxorubicin in MCF-7 cells [17]. The intracellular calcium and survivin levels were reduced significantly, while the combination of apoptotic cells with doxorubicin (5 µg/mL) and D. pentandra extracts were investigated (25 and 50 µg/mL) [17]. In addition, the combination of 5-fluorouracil (5 µg/mL) and ethanolic extracts (50 µg/mL) of D. pentandra was able to increase the apoptosis cells and p21 expression and decrease the survivin expression of HeLa cells [18].…”

“…Although D. pentandra is a semi-parasitic plant, its bioactivities may also depend on its host plant [3]. D. pentandra has been reported to have a high potential for medicinal values such as antioxidants [1,[4][5][6][7][8][9][10], antibacterial [6,7], anticancer, antiproliferative [8,[11][12][13][14][15][16][17][18], antidiabetic, antihyperglycaemic [1,19], anti-inflammatory [20], cytotoxicity [1,14,16], hepatoprotective [19], immunomodulatory [21], and anti-aging [22] activities. The phytochemical analysis of D. pentandra's leaves and flowers also revealed the presence of alkaloids, phenolics, flavonoids, saponins, and terpenoids [5,10,16,23].…”

Molecular Insights into the Specific Targeting of c-MYC G-quadruplex by Cell-Penetrating Peptides: An in silico Study

“…Amber 22 software was used for MD simulations [40,41]. Each of the apo G4s and the dockingpredicted binding complexes were placed at the center of a truncated octahedron box of TIP3P water molecules at a margin distance of 10.0 Å.…”