T cells in aqueous humour from untreated idiopathic uveitis patients

Bertotto, A; Spinozzi, Fabrizio; Vagliasindi, C; Vaccaro, R

doi:10.1136/bjo.79.4.395

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…The presence of CD81 T cells (14) and macrophages within entheseal tissue has been described (15). Interestingly, g/d T cells were enriched in aqueous humor from patients with idiopathic uveitis (16), and IPP-responsive g/d T cells could be isolated from intraocular fluid from patients with Behçet's disease (17).…”

Section: Replymentioning

confidence: 97%

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Reinhardt

Prinz

2017

Arthritis & Rheumatology

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Section: Replymentioning

confidence: 97%

Reply

Reinhardt

Prinz

2017

Arthritis & Rheumatology

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Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Papotto

Reinhardt

Prinz

et al. 2018

Journal of Autoimmunity

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IL-17-producing γδ (γδ17) T cells form a versatile subset of cells that respond rapidly to innate stimuli and support the pro-inflammatory functions of different myeloid and lymphoid lineages, being particularly critical in the early stages of inflammatory and autoimmune responses. In mice, under homeostatic conditions, these innate-like lymphocytes are pre-programmed in the fetal thymus, through an intricate process involving both T cell receptor-dependent and -independent signals, which allows them to readily produce IL-17 upon stimulation. However, given their transcriptional and epigenetic wiring, γδ17 T cells are permissive to different environmental instructions, and can readily acquire the ability to co-produce multiple cytokines, such as IFN-γ, IL-22 and GM-CSF, that further propagate inflammation. Moreover, strong IL-23 signals, which are abundantly found in autoinflammatory conditions, are able to induce de novo differentiation of γδ17 T cells from uncommitted precursors, both in mice and humans. This notwithstanding, the exact mechanisms responsible for γδ17 T cell pathogenicity and multifunctionality are still poorly understood, especially in humans. The pathogenic roles attributed to γδ17 T cells in autoimmune diseases stem mainly from their ability to recruit different inflammatory myeloid populations to the target tissue, and to modulate αβ T cell function, either by enhancing inflammatory T17 responses, or by restraining regulatory T cell activity. Given their capacity to link key inflammatory axes of innate and adaptive immunity, a better understanding of the molecular basis underpinning γδ17 T cell plasticity, and how much this feature accounts for their pathophysiological roles, may be critical for developing novel therapeutic approaches. In this review, we discuss the importance of γδ17 T cells in breaking tolerance and enhancing inflammation in various autoimmune diseases, such as multiple sclerosis, psoriasis and rheumatoid arthritis under the light of their basic biological traits, e.g. development, activation, effector functions and plasticity.

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T cells in aqueous humour from untreated idiopathic uveitis patients

Cited by 2 publications

References 5 publications

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Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

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