T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys

Lenarczyk, Marek; Alsheikh, Ammar J.; Cohen, Eric P.; Schaue, Dörthe; Kronenberg, Amy; Geurts, Aron M.; Klawikowski, Slade; Mattson, David L.; Baker, John E.

doi:10.3390/toxics10120797

Cited by 4 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The engagement of other components of the immune system may be necessary, in addition to macrophages, to cause kidney pathology following irradiation with components of GCRs. In support of this suggestion, irradiation of the kidneys with 10 Gy of X-rays in WAG/RijCmcr rats resulted in infiltration of T cells, natural killer cells, and macrophages is associated with nephropathy [ 25 ]. The 270 day follow up period used here may also have been of insufficient duration to detect other changes in immune cell recruitment to the kidney needed to elicit the development of structural changes in the kidney and a greater increase in blood pressure.…”

Section: Discussionmentioning

confidence: 98%

Exposure to multiple ion beams, broadly representative of galactic cosmic rays, causes perivascular cardiac fibrosis in mature male rats

et al. 2023

Self Cite

View full text Add to dashboard Cite

Long-duration space exploratory missions to the Earth’s moon and the planet Mars are actively being planned. Such missions will require humans to live for prolonged periods beyond low earth orbit where astronauts will be continuously exposed to high energy galactic cosmic rays (GCRs). A major unknown is the potential impact of GCRs on the risks of developing degenerative cardiovascular disease, which is a concern to NASA. A ground-based rat model has been used to provide a detailed characterization of the risk of long-term cardiovascular disease from components of GCRs at radiation doses relevant to future human missions beyond low earth orbit. Six month old male WAG/RijCmcr rats were irradiated at a ground-based charged particle accelerator facility with high energy ion beams broadly representative of GCRs: protons, silicon and iron. Irradiation was given either as a single ion beam or as a combination of three ion beams. For the doses used, the single ion beam studies did not show any significant changes in the known cardiac risk factors and no evidence of cardiovascular disease could be demonstrated. In the three ion beam study, the total cholesterol levels in the circulation increased modestly over the 270 day follow up period, and inflammatory cytokines were also increased, transiently, 30 days after irradiation. Perivascular cardiac collagen content, systolic blood pressure and the number of macrophages found in the kidney and in the heart were each increased 270 days after irradiation with 1.5 Gy of the three ion beam grouping. These findings provide evidence for a cardiac vascular pathology and indicate a possible threshold dose for perivascular cardiac fibrosis and increased systemic systolic blood pressure for complex radiation fields during the 9 month follow up period. The development of perivascular cardiac fibrosis and increased systemic systolic blood pressure occurred at a physical dose of the three ion beam grouping (1.5 Gy) that was much lower than that required to show similar outcomes in earlier studies with the same rat strain exposed to photons. Further studies with longer follow up periods may help determine whether humans exposed to lower, mission-relevant doses of GCRs will develop radiation-induced heart disease.

show abstract

Section: Discussionmentioning

confidence: 98%