Abstract:Introduction: CAR T-cells remain in a quiescent or dormant state when unstimulated, showing no proliferative activity. In contrast, upon specific antigen stimulation (i.e., CD19) CAR T-cells divide both in-vitro and in-vivo, initiate immune responses and can kill their target cells in the body. However, one of the major physiological immune changes with increased age is the progressive impairment of T-cell responses. This process termed immunosenescence (which may be similar T-cell exhaustion) is associated wi… Show more
“… 26 iNKTs from donor 3 were also marked by higher levels of effector memory features, while exhaustion-related genes were significantly less transcribed than in the other donors ( Figure 6 G). We also observed higher expression of genes involved in telomerase activity, recently shown to predict deeper and sustained CAR-T-induced anti-tumor responses 34 , 35 and suggesting that donor 3 cells had high inherent potential for prolonged persistence in vivo . …”
“… 26 iNKTs from donor 3 were also marked by higher levels of effector memory features, while exhaustion-related genes were significantly less transcribed than in the other donors ( Figure 6 G). We also observed higher expression of genes involved in telomerase activity, recently shown to predict deeper and sustained CAR-T-induced anti-tumor responses 34 , 35 and suggesting that donor 3 cells had high inherent potential for prolonged persistence in vivo . …”
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