T-cell subsets and cytokines are indicative of neoadjuvant chemoimmunotherapy responses in NSCLC
Ling Yi,
Ziwei Xu,
Tianyu Ma
et al.
Abstract:Purpose
Neoadjuvant PD-1 blockade combined with chemotherapy is a promising treatment for resectable non-small cell lung cancer (NSCLC), yet the immunological mechanisms contributing to tumor regression and biomarkers corresponding to different pathological responses remain unclear.
Methods
Using dynamic and paired blood samples from NSCLC patients receiving neoadjuvant chemoimmunotherapy, we analyzed the frequencies of CD8 + T-cell and Treg subset… Show more
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