T-cell-rich B-cell lymphoma: a clinicopathologic study of 21 cases and comparison with 43 cases of diffuse large B-cell lymphoma

Akı, Hilal; Tuzuner, Nukhet; Öngören, Şeniz; Başlar, Zafer; Soysal, Teoman; Ferhanoğlu, Burhan; Şahinler, İsmet; Aydın, Yıldız; Ülkü, Birsen; Aktuğlu, Gülten

doi:10.1016/s0145-2126(03)00253-4

Cited by 37 publications

(38 citation statements)

References 27 publications

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“…A male predominance has been noted in most series, in the range of 57%-88% [5,[12][13][14][15][16][17], contrasting with DLBCL, which occurs roughly equally in men and women [1]. Several series have suggested a propensity of T/HRBCL to present with advanced Ann Arbor stage, multiple extranodal sites, and an elevated lactate dehydrogenase level (LDH), though these differences were not significant from traditional DLBCLs in two small case-controlled analyses (Table 1) [ 5,10,12,14,15,17,18]. Most series suggest, however, that T/HRBCL infiltrates the spleen, liver, and bone marrow with greater frequency than DLBCL (Table 1).…”

Section: Clinical Presentationmentioning

confidence: 89%

Section: Clinical Presentationmentioning

confidence: 99%

“…T/HRBCL occurs at a younger age than traditional DLBCL, with a median age in the fourth decade of life [5,9,[12][13][14] compared with the sixth decade for DLBCLs as a whole [1]. A male predominance has been noted in most series, in the range of 57%-88% [5,[12][13][14][15][16][17], contrasting with DLBCL, which occurs roughly equally in men and women [1]. Several series have suggested a propensity of T/HRBCL to present with advanced Ann Arbor stage, multiple extranodal sites, and an elevated lactate dehydrogenase level (LDH), though these differences were not significant from traditional DLBCLs in two small case-controlled analyses (Table 1) [ 5,10,12,14,15,17,18].…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Most series suggest, however, that T/HRBCL infiltrates the spleen, liver, and bone marrow with greater frequency than DLBCL (Table 1). Involvement of the spleen and liver has been reported in 43%-60% and 33%-40% of patients, respectively [5,12,14]. Bone marrow involvement occurs in approximately one third of patients with T/HRBCL, which is considerably higher than in their traditional DLBCL counterparts [1,5,12,14,17].…”

Section: Clinical Presentationmentioning

confidence: 99%

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T-Cell/Histiocyte-Rich B-Cell Lymphoma: Biology, Diagnosis, and Management

Abramson

2006

The Oncologist

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Section: Clinical Presentationmentioning

confidence: 89%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

See 2 more Smart Citations

T-Cell/Histiocyte-Rich B-Cell Lymphoma: Biology, Diagnosis, and Management

Abramson

2006

The Oncologist

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“…It occurs predominately in middle-aged men, and more commonly involves the liver, spleen, and bone marrow than does DLBCL [5][6][7]. Typical clinical manifestations of T/HRBCL include generalized fatigue, varying degrees of abnormal liver tests, and organomegaly [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Masquerading as Autoimmune Hepatitis with Clinical Features of Hemophagocytic Lymphohistiocytosis

Mehta

Wang²,

McHenry³

et al. 2015

J Gastrointest Dig Syst

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We report the case of a 20-year-old male who presented with acute hepatitis resembling autoimmune hepatitis, but subsequently found to be T-Cell Rich/Histiocyte Rich Large B-Cell Lymphoma. Our patient was mistakenly diagnosed with autoimmune hepatitis based on liver histology demonstrating a pronounced lobular and portal infiltrate comprised predominately of polyclonal T cells, in the setting of negative serologic testing. This conclusion was reinforced by a compelling biochemical response to standard immunosuppressive therapy. The correct diagnosis of T/HRBCL subsequently was established by bone marrow biopsy (and confirmed by lymph node biopsy) when the patient presented with clinical features of HLH. In conclusion, our case elucidates a unique clinical spectrum of T/HRBCL. This patient initially presented with acute hepatitis, before mistakenly being diagnosed with autoimmune hepatitis and finally exhibited clinical features of HLH, which led to the diagnosis of T/HRBCL. It is critical to consider lymphoma in the differential for acute hepatopathy and clinical features of HLH.

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Macrophages in T cell/histiocyte rich large B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotype

et al. 2013

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Abundant macrophage infiltration in tumors often correlates with a poor prognosis. T cell/histiocyte rich large B cell lymphoma (THRLBCL) is a distinct aggressive B cell lymphoma entity showing a high macrophage content. To further elucidate the role of tumor-associated macrophages in THRLBCL, we performed gene expression profiling of microdissected histiocyte subsets of THRLBCL, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), Piringer lymphadenitis, sarcoidosis, nonspecific lymphadenitis and monocytes from peripheral blood. In a supervised principal component analysis, histiocytes from THRLBCL were most closely related to epithelioid cells from NLPHL, with both types of cells expressing genes related to proinflammatory and regulatory macrophage activity. Moreover, histiocytes from THRLBCL strongly expressed metal-binding proteins like MT2A, by which histiocytes of THRLBCL can be distinguished from the other histiocyte subsets investigated. Interestingly, the validation at the protein level showed a strong expression of TXN, CXCL9, MT2A and SOD2 not only in macrophages of THRLBCL but also in the tumor cells of NLPHL and classical Hodgkin lymphoma (cHL). Overall, the present findings indicate that macrophages in the microenvironment of THRLBCL have acquired a distinct gene expression pattern that is characterized by a mixed M1/M2 phenotype and a strong expression of several metal binding proteins. The microenvironments in NLPHL and THRLBCL appear to have a similar influence on the macrophage phenotype. The high expression of metal binding proteins in histiocytes of THRLBCL may be diagnostically useful, but a potential pathophysiological role remains to be identified.

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T-cell-rich B-cell lymphoma: a clinicopathologic study of 21 cases and comparison with 43 cases of diffuse large B-cell lymphoma

Cited by 37 publications

References 27 publications

T-Cell/Histiocyte-Rich B-Cell Lymphoma: Biology, Diagnosis, and Management

T-Cell/Histiocyte-Rich B-Cell Lymphoma: Biology, Diagnosis, and Management

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Masquerading as Autoimmune Hepatitis with Clinical Features of Hemophagocytic Lymphohistiocytosis

Macrophages in T cell/histiocyte rich large B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotype

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