T cell responses in senior patients with community-acquired pneumonia related to disease severity

Bian, Lu-Qin; Bi, Ying; Zhou, Su; Chen, Zi-Dan; Jun, Wen; Jin, Shi; Mao, Ling

doi:10.1016/j.yexcr.2017.09.041

Cited by 9 publications

(14 citation statements)

References 22 publications

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“…age-and sex-matched healthy controls [62]. Under in vitro conditions, these cells display impaired capacity to upregulate Foxp3 and Helios transcription and lower TGF-β and IL-10 production.…”

Section: Infectious Diseases In Elderly Pneumonia Patients Cd4 + T Cells From Peripheral Blood Mononuclear Cells Exhibit Reduced Foxp3 Anmentioning

confidence: 96%

“…In elderly pneumonia patients, CD4 + T cells from peripheral blood mononuclear cells exhibit reduced Foxp3 and Helios expression in comparison with age- and sex-matched healthy controls [ 62 ]. Under in vitro conditions, these cells display impaired capacity to upregulate Foxp3 and Helios transcription and lower TGF- β and IL-10 production.…”

Section: Helios-expressing Foxp3 + Tregs and Human Diseasementioning

confidence: 99%

“…Further, CD4 + CD25 + T cells from pneumonia patients have been found to secrete significantly lower levels of cytolytic molecules than those from healthy individuals and to also have poor capacity to suppress effector T cell proliferation. Another interesting finding was that the pneumonia severity index in elderly patients was inversely correlated with the proportion of Foxp3 + and Helios + cells among CD4 + T cells and the level of TGF- β [ 62 ]. In a mouse model of invasive pneumococcal infection, the level of the immunomodulatory cytokine TGF- β in the pneumococcal pneumonia-resistant BALB/c mouse strains was higher than that in susceptible CBA/Ca mouse strains [ 63 ].…”

Section: Helios-expressing Foxp3 + Tregs and Human Diseasementioning

confidence: 99%

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Coexpression of Helios in Foxp3+ Regulatory T Cells and Its Role in Human Disease

et al. 2021

Disease Markers

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Regulatory T cells (Tregs) expressing the Foxp3 transcription factor are indispensable for the maintenance of immune system homeostasis. Tregs may lose Foxp3 expression or be reprogrammed into cells that produce proinflammatory cytokines, for example, Th1-like Tregs, Th2-like Tregs, Th17-like Tregs, and Tfh-like Tregs. Accordingly, selective therapeutic molecules that manipulate Treg lineage stability and/or functional activity might have the potential to improve aberrant immune responses in human disorders. In particular, the transcription factor Helios has emerged as an important marker and modulator of Tregs. Therefore, the current review focuses on recent findings on the expression, function, and mechanisms of Helios, as well as the patterns of Foxp3+ Tregs coexpressing Helios in various human disorders, in order to explore the potential of Helios for the improvement of many immune-related diseases. The studies were selected from PubMed using the library of the Nanjing Medical University in this review. The findings of the included studies indicate that Helios expression stabilizes the phenotype and function of Foxp3+ Tregs in certain inflammatory environments. Further, Tregs coexpressing Helios and Foxp3 were identified as a specific phenotype of stronger suppressor immune cells in both humans and animal models. Importantly, there is ample evidence that Helios-expressing Foxp3+ Tregs are relevant to various human disorders, including connective tissue diseases, infectious diseases, solid organ transplantation-related immunity, and cancer. Thus, Helios+Foxp3+CD4+ Tregs could be a valuable target in human diseases, and their potential should be explored further in the clinical setting.

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Section: Infectious Diseases In Elderly Pneumonia Patients Cd4 + T Cells From Peripheral Blood Mononuclear Cells Exhibit Reduced Foxp3 Anmentioning

confidence: 96%

Section: Helios-expressing Foxp3 + Tregs and Human Diseasementioning

confidence: 99%

Section: Helios-expressing Foxp3 + Tregs and Human Diseasementioning

confidence: 99%

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Coexpression of Helios in Foxp3+ Regulatory T Cells and Its Role in Human Disease

et al. 2021

Disease Markers

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“…However, a controversial issue regarding the effect of aging on the pathogenic model of CAP has recently emerged. CAP patients have decreased cellular immune function (5), and T cell proliferation is decreased in elderly individuals (6). The Pneumonia Severity Index (PSI), which is associated with poor prognosis, is inversely correlated with several parameters related to T cell regulatory function (5,7).…”

Section: Introductionmentioning

confidence: 99%

“…CAP patients have decreased cellular immune function (5), and T cell proliferation is decreased in elderly individuals (6). The Pneumonia Severity Index (PSI), which is associated with poor prognosis, is inversely correlated with several parameters related to T cell regulatory function (5,7). For elderly patients with SCAP, mortality is high among those who require an intensive care unit (ICU) stay (8,9).…”

Section: Introductionmentioning

confidence: 99%

Mortality prediction using clinical and laboratory features in elderly patients with severe community-acquired pneumonia

et al. 2021

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Background: Severe community-acquired pneumonia (SCAP) is a serious health threat in elderly individuals, and a prospective, observational study was conducted to explore the prognostic factors.Methods: Patients (≥65 years old) with SCAP that had an intensive care unit (ICU) stay >24 h were recruited at our center. Clinical and laboratory data were collected and various assessment scores were calculated. The follow-up period was censored at the date of death or at hospital discharge, whichever came first.Results: A total of 120 elderly patients with SCAP were included. Among them, 61 were cured (survival group) and 59 died due to SCAP (mortality group). Multivariate logistic regression analysis showed that chronic obstructive pulmonary disorder (COPD, β=2.061, P=0.008) and CD3+CD4+ T cell count (β=−0.019, P=0.017) were independent prognostic factors for death in elderly patients with SCAP. The area under the receiver operating characteristic (ROC) curve (AUROC) for the age-and gender-adjusted model was estimated to be 0.915 [95% confidence interval (CI): 0.858-0.972] for mortality, and the sensitivity and specificity of the model were 91.53% and 86.89%, respectively.Conclusions: Our findings suggest that COPD and the CD3+CD4+ T cell count are independent prognostic factors for mortality, and the constructed model was moderately accurate in the prediction of mortality for elderly patients with SCAP.

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CD4⁺ T cells related to disease severity in elderly and frailty community‐acquired pneumonia patients: A retrospective cohort study

Wang,

Pei,

Zhao

et al. 2023

Immunity Inflam & Disease

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BackgroundsElderly and frailty individuals show a more senescent immune system, which may relate to worse outcome in community‐acquired pneumonia (CAP). This study aimed to explore prognostic factors related to immune.MethodsSixty of elderly (≥65 years) and frailty (clinical frailty scale ≥5 scores) nonsevere CAP patients and 60 severe CAP (SCAP) patients were recruited at our center. Clinical and laboratory data, and several assessment scores were collected.ResultsCompared with nonsevere CAP group, the elderly and frailty SCAP patients showed higher level of BMI, PaCO2 and lactate in arterial blood‐gas, CURB‐65 score, ICU admission, mechanical ventilation, shock accidence, and longer hospital stay using two‐tailed t test. The SCAP group also showed increased CRP, IL‐6, and PCT, and decreased CD3+ T cells, CD4+ T cells, and CD8+ T cells. Logistic regression analysis showed that CD4+ T cells, IL‐6 and PCT were independent prognostic factors for SCAP. The area under the receiver operating characteristic (ROC) curve for CD4+ T cells combined with PCT was 0.771 (95% CI 0.683–0.859), and the sensitivity and specificity were both 76.7%. Paired t test analysis showed that low CD4+ T cells in SCAP patients increased after treatment.ConclusionsCD4+ T cells decreased in elderly and frailty SCAP patients, and CD4+ T cells combined with PCT were relatively accurate in the prediction of elderly and frailty SCAP.

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T cell responses in senior patients with community-acquired pneumonia related to disease severity

Cited by 9 publications

References 22 publications

Coexpression of Helios in Foxp3+ Regulatory T Cells and Its Role in Human Disease

Coexpression of Helios in Foxp3+ Regulatory T Cells and Its Role in Human Disease

Mortality prediction using clinical and laboratory features in elderly patients with severe community-acquired pneumonia

CD4⁺ T cells related to disease severity in elderly and frailty community‐acquired pneumonia patients: A retrospective cohort study

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T cell responses in senior patients with community-acquired pneumonia related to disease severity

Cited by 9 publications

References 22 publications

Coexpression of Helios in Foxp3+ Regulatory T Cells and Its Role in Human Disease

Coexpression of Helios in Foxp3+ Regulatory T Cells and Its Role in Human Disease

Mortality prediction using clinical and laboratory features in elderly patients with severe community-acquired pneumonia

CD4+ T cells related to disease severity in elderly and frailty community‐acquired pneumonia patients: A retrospective cohort study

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CD4⁺ T cells related to disease severity in elderly and frailty community‐acquired pneumonia patients: A retrospective cohort study