T-Cell Recognition and Cytokine Profile Induced by Melanocyte Epitopes in Patients with HLA-DRB1*0405-Positive and -Negative Vogt-Koyanagi-Harada Uveitis

Damico, Francisco Max; Cunha-Neto, Edécio; Goldberg, Anna Carla; Iwai, Leo Kei; Marin, Maria Lúcia Carnevale; Hammer, Juergen; Kalil, Jorge; Yamamoto, Jiro

doi:10.1167/iovs.04-1273

Cited by 89 publications

(59 citation statements)

References 37 publications

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“…Additionally, melanocyte differentiation proteins, which are potential candidates for the autoimmune response that is observed in VKH, are restricted to HlA-DRb1*0405. [9] A similar association between HlA-DRb1*0401, *0404, *0405, and *01001 alleles and genetic susceptibility to RA has previously been established. [10] ın conclusion, RA is an autoimmune disorder commonly encountered by ophthalmologists, and patients with this disease may present with a variety of ocular manifestations.…”

Section: Discussionsupporting

confidence: 65%

Vogt-Koyanagi-Harada Disease Associated with Rheumatoid Arthritis

et al. 2013

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Otuz bir yaşında erkek hasta, iki taraflı bulanık görme ve fotofobi yakınmaları ile kliniğimize başvurdu. Hastanın aynı zamanda şiddetli baş ağrısı, çınlama ve sabah tutukluğu ve artralji yakınmaları vardı. Hastanın tıbbi öyküsünde sekiz yıldır romatoid artrit (RA) nedeniyle tedavi edildiği öğrenildi. Düzeltilmiş görme keskinliği sol gözde 20/50 ve sağ gözde 20/40 düzeyindeydi. Oküler muayenede iki taraflı panüveit ve seröz retina dekolmanı izlendi. Optik koherens tomografide (OCT) iki taraflı subretinal sıvı varlığı tespit edilirken, floresein anjiyografide (FA) "yıldızlı gökyüzü" görünümü ve optik disk boyanması gözlendi. Klinik, FA ve OCT bulguları ışığında hastaya Vogt-Koyanagi-Harada (VKH) hastalığı tanısı konuldu. Sonuç olarak, RA ve VKH hastalığı, etyopatogenezinde çeşitli benzer genetik ve çevresel faktörleri paylaşmaktadır. Bu nedenle bu iki otoimmün hastalık arasındaki ilişkiyi ortaya koyan ileri araştırmalar gerekmektedir.Anahtar sözcükler: Romatoid artrit; seröz retina dekolmanı; VogtKoyanagi-Harada hastalığı.A 31-year-old male patient was admitted to our eye clinic with the complaints of bilateral blurred vision and photophobia. He also suffered from a severe headache, tinnitus, morning stiffness, and arthralgias. His medical history revealed that he had been receiving care for rheumatoid arthritis (RA) for eight years. The best corrected visual acuity was 20/50 in the left eye and 20/40 in the right. His ocular examination revealed bilateral panuveitis with serous retinal detachment. Optical coherence tomography (OCT) confirmed the presence of bilateral subretinal fluid, while fluorescein angiography (FA) demonstrated a "starry sky" appearance and optic disc staining. The patient was diagnosed with Vogt-Koyanagi-Harada (VKH) disease based on the clinical, FA, and OCT findings. In conclusion, both RA and VKH disease share many similar genetic and environmental factors in their etiopathogenesis. Therefore,further investigations are required to confirm the association between these two autoimmune diseases.

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Section: Discussionsupporting

confidence: 65%

Vogt-Koyanagi-Harada Disease Associated with Rheumatoid Arthritis

et al. 2013

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“…Gocho et al isolated T cell clones from PBMC of patients specific for tyrosinase family proteins with predominant Th 1 cytokine profile (11) . Damico et al demonstrated that PBMC of patients recognize an increased breadth of melanocyte protein-derived peptides with higher affinity than control subjects and do not produce IL-4, a Th 2 cytokine, in response to disease-specific peptides (12) . Differences in cytokine concentrations in CSF and sera of patients with VKH corroborate a Th 1 -dominant condition in VKH (13) .…”

Section: Role Of Cd4 + T Cellsmentioning

confidence: 99%

“…In that study, the different alleles originally proposed to be associated with VKH were present separately, reinforcing the importance of HLA-DRB1*0405 as the main susceptibility allele to VKH (18) . The importance of this allele in susceptibility to the development of VKH was reinforced by Damico et al, who showed that patients bearing HLA-DRB1*0405 recognized a larger melanocyte-derived peptide repertoire than HLA-matched control subjects (12) .…”

Section: Immunogeneticsmentioning

confidence: 99%

“…Several authors showed cellular immune response of peripheral T cells or T cells from intraocular fluid against peptides derived from tyrosinase and its related proteins (12,19) . MART-1.…”

Section: Search For a Target In Vkhmentioning

confidence: 99%

“…Chan et al showed that experimental melanin-protein induced uveitis can be ameliorated by a recombinant adenovirus construct encoding gp100 (21) . However, some authors studied peptides derived from this protein but VKH relevant peptides were not found in VKH patients (12) . Several peptides selected from tyrosinase, TRP-1 and TRP-2 are restricted to HLA-DRB1*0405 and are potential candidates for the autoimmune response observed in VKH.…”

Section: Search For a Target In Vkhmentioning

confidence: 99%

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A Woman With Bilateral Retinal Detachments

Kanu

2019

JAMA Ophthalmol

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A 33-year-old otherwise healthy black woman presented to the emergency department for evaluation of blurry vision in both eyes. She had no relevant medical, family, or ocular history. There was no history of trauma or ocular surgery. One month prior to presentation, she had developed fevers, chills, and coughing. After several days, she had developed redness, pain, photophobia, and blurry vision in her left eye, and she had subsequently developed similar symptoms in her right eye. On presentation, her visual acuity was counting fingers OU. Intraocular pressures were 14 mm Hg OU. A slitlamp examination revealed mild conjunctival redness, 2+ anterior chamber cell, and flare in both eyes, as well as mild posterior synechiae. The cornea was clear without keratic precipitates, and there were no iris nodules. Pigment was present on the anterior lens capsule. A fundus examination demonstrated a moderate amount of vitreous cell, hyperemia and edema of the optic disc, and retinal detachments in both eyes (Figure). The detachments were inferior and shifted with the patient's head position, suggesting serous detachments. Findings were similar bilaterally. A B-scan ultrasonographic test demonstrated bullous retinal detachments and diffusely thickened choroid.

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T-Cell Recognition and Cytokine Profile Induced by Melanocyte Epitopes in Patients with HLA-DRB1*0405-Positive and -Negative Vogt-Koyanagi-Harada Uveitis

Cited by 89 publications

References 37 publications

Vogt-Koyanagi-Harada Disease Associated with Rheumatoid Arthritis

Vogt-Koyanagi-Harada Disease Associated with Rheumatoid Arthritis

New insights into Vogt-Koyanagi-Harada disease

A Woman With Bilateral Retinal Detachments

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