Abstract:The T‐cell receptor β‐chain (Tβ) gene expression was examined in 16 children with B‐lineage acute lymphoblastic leukemia (ALL), including eight patients with rearrangement of the Tβ gene as well as immunoglobulin (Ig) heavy chain gene rearrangement. In contrast to the 1.3 kb full‐length transcripts of the Tβ gene observed in T‐lineage leukemia and lymphoma cells, no transcript of the Tβ gene was detected in 10 patients, including four with Tβ gene rearrangement. Low levels of Tβ transcripts were found in three… Show more
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